ABSTRACT
We describe a patient with lymphocytic leukemia who developed multiple, disseminated, vesiculopustular eruptions in combination with perianal ulcer. Four years earlier, she had a herpes zoster (HZ) infection involving the ophthalmic division of her left trigeminal nerve with subsequent postherpetic neuralgia that was treated with steroids. After the studies, we concluded that the patient had a recurrent disseminated HZ infection and perianal ulcer caused by cytomegalovirus (CMV).
Subject(s)
Cytomegalovirus Infections/complications , Fissure in Ano/complications , Herpes Zoster/complications , Skin Ulcer/complications , Aged , Aged, 80 and over , Antiviral Agents/therapeutic use , Cytomegalovirus Infections/drug therapy , Cytomegalovirus Infections/virology , Female , Fissure in Ano/drug therapy , Fissure in Ano/virology , Ganciclovir/therapeutic use , Herpes Zoster/drug therapy , Herpes Zoster/virology , Humans , Leukemia, Lymphoid/complications , Recurrence , Skin Ulcer/drug therapy , Skin Ulcer/virologyABSTRACT
OBJECTIVE: Risk stratification of patients with nonsustained ventricular tachycardia (NSVT) and chronic chagasic cardiomyopathy (CCC). METHODS: Seventy eight patients with CCC and NSVT were consecutively and prospectively studied. All patients underwent to 24-hour Holter monitoring, radioisotopic ventriculography, left ventricular angiography, and electrophysiologic study. With programmed ventricular stimulation. RESULTS: Sustained monomorphic ventricular tachycardia (SMVT) was induced in 25 patients (32%), NSVT in 20 (25.6%) and ventricular fibrillation in 4 (5.1%). In 29 patients (37.2%) no arrhythmia was inducible. During a 55. 7-month-follow-up, 22 (28.2%) patients died, 16 due to sudden death, 2 due to nonsudden cardiac death and 4 due to noncardiac death. Logistic regression analysis showed that induction was the independent and main variable that predicted the occurrence of subsequent events and cardiac death (probability of 2.56 and 2.17, respectively). The Mantel-Haenszel chi-square test showed that survival probability was significantly lower in the inducible group than in the noninducible group. The percentage of patients free of events was significantly higher in the noninducible group. CONCLUSION: Induction of SMVT during programmed ventricular stimulation was a predictor of arrhythmia occurrence cardiac death and general mortality in patients with CCC and NSVT.
Subject(s)
Chagas Cardiomyopathy/physiopathology , Tachycardia, Ventricular/physiopathology , Adult , Aged , Chagas Cardiomyopathy/mortality , Chi-Square Distribution , Chronic Disease , Death, Sudden , Electrocardiography , Electrocardiography, Ambulatory , Female , Humans , Male , Middle Aged , Prospective Studies , Regression Analysis , Risk Factors , Statistics, Nonparametric , Tachycardia, Ventricular/mortalityABSTRACT
The Aedes egypti mosquito fed consistently on guinea-pigs in a 2-hour period (n = 61), the mean percent feeding rate (+/- S.D.) being 88.84 +/- 9.32. Of a total of 34 different compounds systematally administered in guinea-pigs and tested for their effect on the mosquito biting rate using the above model, five: heparin, sodium fluoride, aminocaproic acid, thiourea and dithiocarb partially reduced the biting rate. The results are consistent with the view that certain aminoacids or proteins of blood or tissues serve as 'pheromones' attracting the mosquito to guinea-pigs.
