ABSTRACT
In Washington State, health care workers have the highest rate of compensable back injuries. Washington Hospital Services, a self-insured workers' compensation program, implemented a zero lift program in 31 of its 38 hospitals. Zero lift was defined as replacing manual lifting, transferring, and re-positioning of patients with mechanical lifting or use of other patient assist devices. This program included two trusts, two pools of hospitals that self-insure workers' compensation. The pools are governed by elected boards of trustees from the pool memberships and regulated by the State Department of Labor and Industries. This pretest-posttest descriptive study compared patient-handling injury data prior to program implementation with those after program implementation. Patient-handling injury claims decreased by 43% in the participating hospitals from 2000 to 2004 (i.e., from 3.51 to 2.23). The time lost frequency rate decreased by 50% (i.e., from 1.91 to 1.03).
Subject(s)
Accidents, Occupational/prevention & control , Back Injuries/prevention & control , Hospitals, Rural , Lifting/adverse effects , Occupational Health Services/organization & administration , Accidents, Occupational/statistics & numerical data , Back Injuries/economics , Back Injuries/epidemiology , Back Injuries/etiology , Causality , Cost of Illness , Ergonomics/methods , Hospital Bed Capacity, 100 to 299 , Hospital Bed Capacity, under 100 , Humans , Inservice Training/organization & administration , Insurance Claim Reporting/statistics & numerical data , Mass Screening/organization & administration , Nursing Assessment/organization & administration , Organizational Policy , Personnel, Hospital/education , Program Evaluation , Safety Management/methods , Transportation of Patients/methods , Washington/epidemiology , Workers' Compensation/economicsABSTRACT
The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.
