[Sudden cardiac death: epidemiology and modern therapy]. / La mort subite: de l' épidémiologie à la prévention.

Sudden Cardiac Death (SCD) has become an important public health challenge in the Western World. In Switzerland near 10,000 people suffer each year from SCD. The survival from SCD to hospital discharge is discouraging (near 5%). Large majority of events occur unexpectedly in the out-of-hospital environment and are not predicted with great accuracy by risk profiling. Because the majority of SCD occur by the mechanism of ventricular fibrillation, community-based defibrillation strategies have emerged as one approach to SCD problem. Newer strategies of defibrillation designed to respond faster to out-of-hospital cardiac arrest, including public access defibrillation, as well as aggressive primary and secondary prevention of coronary artery disease appears as the best approach for successful management of SCD.

[What do we actually know about out-of-hospital cardiac arrest?]. / Arrêt cardiaque extrahospitalier: la situation actuelle.

Each year at least 300,000 people in the United States and 8000 to 10,000 people in Switzerland suffer from out-of-hospital cardiac arrest, mostly due to ventricular fibrillation. Early defibrillation provides definitive treatment for most of cardiac arrest victims. Semi-automatic external defibrillators are easy to handle devices allowing to deliver an early electric shock and can be successfully used by lay people following minimal training. Newer strategies of defibrillation designed to respond faster to out-of-hospital cardiac arrest, including public access defibrillation, as well as improvement of each link of the chain of survival appears as the best strategy for the management of out-of-hospital cardiac arrest.

Prospective evaluation of patients with syncope: a population-based study.

PURPOSE: To determine the diagnostic yield of a standardized sequential evaluation of patients with syncope in a primary care teaching hospital. PATIENTS AND METHODS: All consecutive patients who presented to the emergency department with syncope as a chief complaint were enrolled. Their evaluation included initial and routine clinical examination, including carotid sinus massage, as well as electrocardiography and basic laboratory testing. Targeted tests, such as echocardiography, were used when a specific entity was suspected clinically. Other cardiovascular tests (24-hour Holter monitoring, ambulatory loop recorder ECG, upright tilt test, and signal-averaged electrocardiography) were performed in patients with unexplained syncope after the initial steps. Electrophysiologic studies were performed in selected patients only as clinically appropriate. Follow-up information on recurrence and mortality were obtained every 6 months for as long as 18 months for 94% (n = 611) of the patients. RESULTS: After the initial clinical evaluation, a suspected cause of syncope was found in 69% (n = 446) of the 650 patients, including neurocardiogenic syncope (n = 234, 36%), orthostatic hypotension (n = 156, 24%), arrhythmia (n = 24, 4%), and other diseases (n = 32, 5%). Of the 67 patients who underwent targeted tests, suspected diagnoses were confirmed in 49 (73%) patients: aortic stenosis (n = 8, 1%), pulmonary embolism (n = 8, 1%), seizures/stroke (n = 30, 5%), and other diseases (n = 3). Extensive cardiovascular workups, which were performed in 122 of the 155 patients in whom syncope remained unexplained after clinical assessment, provided a suspected cause of syncope in only 30 (25%) patients, including arrhythmias in 18 (60%), all of whom had abnormal baseline ECGs. The 18-month mortality was 9% (n = 55, including 8 patients with sudden death); syncope recurred in 15% (n = 95) of the patients. CONCLUSION: The diagnostic yield of a standardized clinical evaluation of syncope was 76%, greater than reported previously in unselected patients. Electrocardiogram-based risk stratification was useful in guiding the use of specialized cardiovascular tests.

Safety of radiofrequency catheter ablation of accessory atrioventricular pathways.

The acute anatomic and valvular consequences of radiofrequency catheter ablation of accessory pathways were evaluated in 62 patients by means of serial echocardiographic examinations. Semiquantitative assessment of valvular incompetence and classification into one of four grades according to the width and the extension of the jet from the valvular orifice were carried out. Segmental wall motion abnormalities were evaluated semiquantitatively with four grades of severity (normal, hypokinesia, akinesia, or dyskinesia). New echocardiographic abnormalities were observed in five patients. One thrombus on the ventricular aspect of the mitral valve, three hemodynamically insignificant pericardial effusions, and one increase in severity of tricuspid incompetence were found 1 day after radiofrequency catheter ablation. We conclude that echocardiographic changes after radiofrequency ablation of accessory pathways are rare and of minor significance. These findings confirm the safety of the procedure.

Value of the 12-lead electrocardiogram in arrhythmogenic right ventricular dysplasia, and absence of correlation with echocardiographic findings.

The 12-lead electrocardiogram during sinus rhythm was studied in 20 patients with arrhythmogenic right ventricular (RV) dysplasia with symptomatic ventricular tachycardia. Findings were analyzed, together with echocardiographic evaluation of site, extent and progression of RV wall abnormalities. Electrocardiographic abnormalities were found in 90% of patients. No correlation was found between abnormalities on the initial 12-lead electrocardiogram, and the echocardiographic extent and location of RV involvement. Over time, echocardiographic progression of the disease was observed; RV size increased in 6 of 7 patients from 34 +/- 3 to 39 +/- 3 mm (p = 0.01), and there was progression in the extent of RV wall motion abnormalities in 4 of 7 patients. Analysis of serial electrocardiographic recordings did not reveal changes indicative of progression of the disease during follow-up of 71 +/- 48 months. It is concluded that electrocardiographic abnormalities suggesting arrhythmogenic RV dysplasia are present in 90% of symptomatic patients on the first electrocardiogram recorded during sinus rhythm. However, serial electrocardiographic recordings in these patients do not provide information regarding anatomic progression of the disease.

[Diagnosis and treatment of paroxysmal tachycardia]. / Diagnosestellung und Behandlung paroxysmaler Tachykardien.

The practising physician's knowledge of paroxysmal attacks of tachycardia is frequently disappointing. In this article a description is given of mechanisms and possible sites of origin of tachycardia. This is followed by a discussion on the typical history and the findings in these patients. Lastly, therapeutic guidelines are given. A discussion of the electrocardiographic features of the different types of paroxysmal tachycardias falls outside the scope of this article.

Cardiac transplantation: the changing faces of immunosuppression.

Many advances have been made in immunosuppressive therapy and other aspects of cardiac transplant management since the first cardiac transplantation was performed in the late 1960s. The cellular immune response and rejection process are better understood. This knowledge changed the way existing drugs were used to control rejection and led to the development of new drugs that could more effectively control the rejection process. Early drug protocols used combinations of azathioprine, antilymphocyte globulin, and steroids. Later protocols used combinations of cyclosporine, steroids, and antithymocyte globulin. After problems related to cyclosporine were identified, protocols came full circle. They now include drugs that were used in earlier protocols, as well as cyclosporine. The purpose of this article is to describe how protocols for immunosuppressive therapy have evolved based on our expanded knowledge of immunosuppression and methods of best using new and old drugs to achieve this goal.

Immediate reconstruction of simple lacerations.

A subjective description of a technique of immediate reconstruction of cutaneous defects due to laceration is presented. Extension of the use and range of the Z-plasty is emphasized and its benefits and limitations are discussed. The reconstructive surgeon is challenged to consider wider and more frequent use of these methods.

The prevention of postanesthetic delirium.

We recommend the use of one dose of physostigmine salicylate, a few minutes before the termination of a general anesthetic, to prevent confusion, struggling, disorientation, or delirium during the recovery from anesthesia. We believe that it is well to prevent such behavior, particularly in patients who have just undergone reconstructive surgery where the unmanageable behavior could jeopardize surgical results. Our results indicate that such behavior is largely preventable.

Ferris Smith.

Important events and renowned persons are seen and remembered differently by those who live the happening or know the person. In As I Remember Ferris Smith, four of his trainees provide a kaleidoscopic view of the doyen.