An Intersectional Analysis of LGBTQ Online Media Coverage of the Pulse Nightclub Shooting Victims.

This study illustrates the radical potential of intersectionality to offer a more deeply critical analysis of hierarchies in lesbian, gay, bisexual, transgender, and queer (LGBTQ) communities. The author examines how 377 reports from the five most-trafficked LGBTQ Web sites represented victims of the Pulse nightclub shooting in Orlando, FL. Findings support previous scholarship that has emphasized Latinx exclusion, as the articles generally failed to present the victims in an intersectional way, focusing on their LGBTQ status and excluding their Latinx identities. At the same time, a significant minority of the reports emphasized Latinx queer people, most frequently in a way that continued to prioritize LGBTQ identification, sometimes even advancing stereotypical representations of Latinx communities as extraordinarily focused on faith, family, or "machismo." Moreover, none of the articles considered xenophobia as a potential motivating factor in the shooting, and the reports typically presented policing agencies in a neutral, and sometimes even positive, way.

Implementation of an integrated longitudinal curricular activity for graduating pharmacy students.

OBJECTIVES: To evaluate whether a novel integrated longitudinal curricular activity to prepare graduating doctor of pharmacy (PharmD) students for 2 comprehensive examinations was successful, and to assess whether it engaged other pharmacy students in curricular discussion and learning. DESIGN: Thirty-eight of 91graduating third-year (P3) students in a PharmD program formed 11 teams to create and present pharmacotherapeutic posters to their peers. The impact of the novel activity on graduating students' performance on the North American Pharmacist Licensure Examination (NAPLEX) and a comprehensive commercial examination was assessed. All first-year (P1), second-year (P2), and P3 students reviewed and discussed the content of each poster. ASSESSMENT: Participants in the integrated longitudinal curricular activity performed better than nonparticipants on the commercial examination (p=0.023) and NAPLEX (p=0.033). However, regardless of participation, commercial examination scores predicted a significant amount of variance (ie, 34%) in NAPLEX scores. The P3 participants (83%) believed the curricular activity assisted them in their NAPLEX preparation, while 75% of P1 students, 79% of P2 students, and 80% of P3 students agreed that poster review provided an effective summary of different disease states. Ninety percent of faculty poster evaluators reported that the posters were professional, and all evaluators agreed that participants effectively conveyed their message to the intended audience. CONCLUSION: The integrated longitudinal curricular activity provided a positive learning environment for all pharmacy students and may have better prepared graduating students' for the NAPLEX.

Sexual orientation and fear at night: gender differences among sexual minorities and heterosexuals.

Using data from the 2000-2010 General Social Survey, a nationally representative sample of 5,086 adults in the United States, the authors examine sexual orientation and gender differences in reports of being afraid to walk alone at night. Results indicate that sexual minorities are significantly more likely to report fear at night than heterosexuals, and women are significantly more likely to report such fear than men. Further, our findings suggest that these sexual orientation and gender differences are due to sexual minority men being more likely than heterosexual men to report fear at night. Thus, the results of this study reveal that three groups--heterosexual women, sexual minority women, and sexual minority men--do not differ from one another in reporting fear, yet these groups are all more likely than heterosexual men to report fear at night. These findings give weight to the importance of investigating the intersection of sexual orientation and gender in individuals' reports of fear.

Sirolimus-associated hepatotoxicity in liver transplantation.

BACKGROUND: Sirolimus is an immunosuppressant that exerts anti-rejection activity by inhibiting T-cell activity and is used to treat chronic rejection and calcineurin-related nephrotoxicity. Unlike tacrolimus and cyclosporine, it has no effect on calcineurin activity in liver transplant recipients. OBJECTIVE: To report correlates of survival outcomes in a series of patients with putative sirolimus-related hepatotoxicity after liver transplant. METHODS: We retrospectively reviewed the medical records of patients who underwent a liver transplant for chronic hepatitis C virus (HCV) and who received sirolimus immunosuppressive therapy between November 2000 and November 2003. Extracted data included sirolimus serum concentrations, frequency of sirolimus-related adverse effects, drug-related clinical hepatitis, and survival outcomes. RESULTS: Ten patients were found to have been treated with sirolimus for either renal insufficiency (n = 6) or chronic rejection (n = 4). Six patients had liver biopsies, while the remaining 4 patients were clinically diagnosed with rejection. Two of the 6 patients demonstrated changes consistent with sinusoidal congestion and one with eosinophilia, consistent with an allergic drug reaction. HCV viral load increased slightly, from 600 000 to 700 000 IU/mL. Mean baseline transaminase levels were 45 IU/L for aspartate aminotransferase and 50 IU/L for alanine aminotransferase, with peak levels of 210 and 180 IU/L, respectively. The time to transaminase increase was a mean of 21 days when sirolimus was added, with resolution within 27 days (mean) after its discontinuation. No changes were evident in antiviral therapy. Combination sirolimus and tacrolimus concentrations were maintained at >10 ng/mL; average monotherapy with sirolimus was 12 ng/mL, and average time on therapy was 25 weeks. CONCLUSIONS: Sirolimus-related hepatotoxicity is an important complication after liver transplant. Immediate recognition is critical to avoid confusion with other causes of abnormal serum aminotransferases after liver transplant, and discontinuation of the drug may be required.