Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 21
Filter
1.
Congenit Heart Dis ; 9(3): 259-65, 2014.
Article in English | MEDLINE | ID: mdl-24034170

ABSTRACT

BACKGROUND/OBJECTIVE: Cardiopulmonary exercise capacity is often reduced in patients with transposition of the great arteries after atrial switch operation. Reduced exercise capacity may be caused by deterioration of systemic right ventricular function over time. This study analyzed serial changes in systemic right ventricular function and cardiopulmonary exercise capacity in young adults with transposition of the great arteries after atrial redirection surgery. METHODS: Twenty-one patients (37% female, mean age 23.2 ± 3.3, mean age at surgery 12.8 ± 14 years) with transposition of the great arteries after atrial switch operation were included in this study. Patients were followed up for a mean period of 39.6 ± 13.1 months. Exercise capacity expressed as peak VO2 max, systemic right ventricular function and subpulmonary left ventricular function assessed by cardiac magnetic resonance imaging and NT-proBNP levels were obtained at baseline and follow-up. Changes in peak VO2 max were correlated to changes in cardiac magnetic resonance imaging and NT-proBNP levels. RESULTS: Baseline peak VO2 max decreased significantly (28.31 ± 5.80 mL/kg/min vs. 25.17 ± 5.71 mL/kg/min, P = .005) on follow-up. Cardiac magnetic resonance imaging parameters of systemic right ventricular ejection fraction as well as subpulmonary left ventricular ejection fraction remained unchanged (44.68 ± 6.59% vs. 45.65 ± 9.60%, P = .54, 60.18 ± 6.29% vs. 61.52 ± 5.30%, P = .35). NT-proBNP levels did not increase (211.7 ± 85.7 ng/mL vs. 261.2 ± 182.2 ng/mL, P = .16). CONCLUSIONS: After atrial switch operation for transposition of the great arteries we observed a declining functional exercise capacity. This was not associated with worsening systemic right ventricular function, suggesting that other factors are contributing to the decline in physical exercise capacity.


Subject(s)
Cardiac Surgical Procedures/adverse effects , Exercise Tolerance , Transposition of Great Vessels/surgery , Ventricular Dysfunction, Right/etiology , Ventricular Function, Right , Adult , Age Factors , Biomarkers/blood , Exercise Test , Female , Germany , Humans , Magnetic Resonance Imaging , Male , Natriuretic Peptide, Brain/blood , Oxygen Consumption , Peptide Fragments/blood , Retrospective Studies , Risk Factors , Time Factors , Transposition of Great Vessels/diagnosis , Transposition of Great Vessels/physiopathology , Treatment Outcome , Ventricular Dysfunction, Right/blood , Ventricular Dysfunction, Right/diagnosis , Ventricular Dysfunction, Right/physiopathology , Ventricular Function, Left , Young Adult
2.
Int J Cardiol ; 170(1): 24-9, 2013 Dec 05.
Article in English | MEDLINE | ID: mdl-24207068

ABSTRACT

BACKGROUND: Exercise training safely and efficiently improves symptoms in patients with heart failure due to left ventricular dysfunction. However, studies in congenital heart disease with systemic right ventricle are scarce and results are controversial. In a randomised controlled study we investigated the effect of aerobic exercise training on exercise capacity and systemic right ventricular function in adults with d-transposition of the great arteries after atrial redirection surgery (28.2 ± 3.0 years after Mustard procedure). METHODS: 48 patients (31 male, age 29.3 ± 3.4 years) were randomly allocated to 24 weeks of structured exercise training or usual care. Primary endpoint was the change in maximum oxygen uptake (peak VO2). Secondary endpoints were systemic right ventricular diameters determined by cardiac magnetic resonance imaging (CMR). Data were analysed per intention to treat analysis. RESULTS: At baseline peak VO2 was 25.5 ± 4.7 ml/kg/min in control and 24.0 ± 5 ml/kg/min in the training group (p=0.3). Training significantly improved exercise capacity (treatment effect for peak VO2 3.8 ml/kg/min, 95% CI: 1.8 to 5.7; p=0.001), work load (p=0.002), maximum exercise time (p=0.002), and NYHA class (p=0.046). Systemic ventricular function and volumes determined by CMR remained unchanged. None of the patients developed signs of cardiac decompensation or arrhythmias while on exercise training. CONCLUSIONS: Aerobic exercise training did not detrimentally affect systemic right ventricular function, but significantly improved exercise capacity and heart failure symptoms. Aerobic exercise training can be recommended for patients following atrial redirection surgery to improve exercise capacity and to lessen or prevent heart failure symptoms. ( CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov #NCT00837603).


Subject(s)
Exercise Tolerance/physiology , Exercise/physiology , Transposition of Great Vessels/physiopathology , Transposition of Great Vessels/surgery , Ventricular Function, Right/physiology , Adult , Female , Follow-Up Studies , Humans , Male , Transposition of Great Vessels/therapy
3.
PLoS One ; 8(2): e55278, 2013.
Article in English | MEDLINE | ID: mdl-23460784

ABSTRACT

OBJECTIVES: Shiga-toxin producing O157:H7 Entero Haemorrhagic E. coli (STEC/EHEC) is one of the most common causes of Haemolytic Uraemic Syndrome (HUS) related to infectious haemorrhagic colitis. Nearly all recommendations on clinical management of EHEC infections refer to this strain. The 2011 outbreak in Northern Europe was the first to be caused by the serotype O104:H4. This EHEC strain was found to carry genetic features of Entero Aggregative E. coli (EAEC) and extended spectrum ß lactamase (ESBL). We report symptoms and complications in patients at one of the most affected centres of the 2011 EHEC O104 outbreak in Northern Germany. METHODS: The courses of patients admitted to our hospital due to bloody diarrhoea with suspected EHEC O104 infection were recorded prospectively. These data include the patients' histories, clinical findings, and complications. RESULTS: EHEC O104 infection was confirmed in 61 patients (female = 37; mean age: 44±2 years). The frequency of HUS was 59% (36/61) in our cohort. An enteric colonisation with co-pathogens was found in 57%. Thirty-one (51%) patients were treated with plasma-separation/plasmapheresis, 16 (26%) with haemodialysis, and 7 (11%) with Eculizumab. Patients receiving antibiotic treatment (n = 37; 61%) experienced no apparent change in their clinical course. Twenty-six (43%) patients suffered from neurological symptoms. One 83-year-old patient died due to comorbidities after HUS was successfully treated. CONCLUSIONS: EHEC O104:H4 infections differ markedly from earlier reports on O157:H7 induced enterocolitis in regard to epidemiology, symptomatology, and frequency of complications. We recommend a standard of practice for clinical monitoring and support the renaming of EHEC O104:H4 syndrome as "EAHEC disease".


Subject(s)
Hemolytic-Uremic Syndrome/microbiology , Hemolytic-Uremic Syndrome/pathology , Hospitalization , Adult , Blood Platelets/pathology , Coinfection/blood , Coinfection/complications , Coinfection/microbiology , Coinfection/virology , Creatinine/blood , Disease Progression , Endoscopy , Enterohemorrhagic Escherichia coli , Feces/microbiology , Female , Gastrointestinal Tract/microbiology , Gastrointestinal Tract/pathology , Germany/epidemiology , Hemolytic-Uremic Syndrome/diagnostic imaging , Hemolytic-Uremic Syndrome/epidemiology , Hospitalization/statistics & numerical data , Humans , L-Lactate Dehydrogenase/metabolism , Male , Prospective Studies , Time Factors , Ultrasonography
4.
Congenit Heart Dis ; 7(2): 139-44, 2012.
Article in English | MEDLINE | ID: mdl-22011205

ABSTRACT

Anomalies of the coronary arteries are commonly associated with congenital heart disease (CHD). Anomalies include variations in number, shape, and location of the origin, as well as the course of the coronary artery. An intramural course of one of the coronary arteries is a rather rare condition. Most cases of anomalies are of no clinical relevance and are found incidentally during evaluation for other cardiac conditions. However, they become of importance when cardiac surgery/intervention, especially valve replacement, needs to be performed. We conducted a literature review for coronary anomalies with an intramural course in patients with CHD and include three cases from our own clinic. Note that transposition of the great arteries seems to be the condition most frequently associated with an intramural course of one of the coronary arteries. In case of a suspected anomaly, transesophageal echocardiography presents a valuable tool to visualize the origin and course of the coronary artery, as well as the relationship to important anatomical structures like the aortic or pulmonary valve. Alternatively, cardiac magnetic resonance imaging can be used. Although rare, both cardiologists and surgeons need to be aware of intramural courses of coronary arteries to prevent accidental trauma to them and thereby, reducing the risk for the patient.


Subject(s)
Aortic Valve Insufficiency/complications , Coronary Vessel Anomalies/complications , Mitral Valve Insufficiency/complications , Mitral Valve Prolapse/complications , Pulmonary Valve Insufficiency/complications , Adult , Aortic Valve Insufficiency/diagnostic imaging , Coronary Vessel Anomalies/diagnostic imaging , Female , Humans , Male , Middle Aged , Mitral Valve Insufficiency/diagnostic imaging , Mitral Valve Prolapse/diagnostic imaging , Pulmonary Valve Insufficiency/diagnostic imaging , Radiography , Tetralogy of Fallot/complications , Tetralogy of Fallot/surgery , Ultrasonography , Young Adult
5.
Int J Cardiol ; 154(1): 14-6, 2012 Jan 12.
Article in English | MEDLINE | ID: mdl-20843567

ABSTRACT

BACKGROUND: ACE inhibition is an established treatment regimen in patients with congestive heart failure due to left ventricular dysfunction which improves morbidity and mortality. However, little is known about the beneficial effects of ACE inhibition in adult patients after Mustard procedure for transposition of the great arteries with heart failure symptoms. Therefore, we investigated the effects of ACE inhibition in these patients on heart failure symptoms, echocardiographic diameters, NT-proBNP and exercise capacity. METHODS: In 14 patients (age 25.2 ± 3.5 years), after Mustard procedure for transposition of the great arteries (age at operation 1.1 ± 1.3 years) with heart failure NYHA II (New York Heart Association class), an ACE inhibition was initiated. At baseline and 13.3 ± 4.0 months after treatment with enalapril (10mg twice a day), echocardiography, exercise test and NT-proBNP measurements were performed and compared to an age- and sex-matched control group. RESULTS: Maximum oxygen uptake and echocardiographic parameters did not change significantly in both groups. However, NT-proBNP showed a significant decrease in the treatment group (242 ± 105 vs. 151 ± 93 ng/l, p=0.004), while in the control group a significant increase (120 ± 89 vs. 173 ± 149 ng/l, p<0.05) was observed. Furthermore, ACE inhibitor treatment did not result in a deterioration of heart failure symptoms or renal function. CONCLUSIONS: Thus, ACE inhibitor treatment of heart failure symptoms in patients with a systemic right ventricle is safe and reduces NT-proBNP levels significantly as a marker for ventricular overload. Nevertheless, larger scale trials are warranted to show effects on morbidity and mortality in this highly selected patient group.


Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Enalapril/therapeutic use , Heart Failure/drug therapy , Adult , Angiotensin-Converting Enzyme Inhibitors/adverse effects , Cardiac Surgical Procedures/adverse effects , Cardiac Surgical Procedures/methods , Enalapril/adverse effects , Female , Heart Ventricles , Humans , Male , Postoperative Complications/drug therapy , Retrospective Studies , Transposition of Great Vessels/surgery , Young Adult
6.
Clin Res Cardiol ; 101(4): 297-303, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22159895

ABSTRACT

BACKGROUND: Patients with patent foramen ovale (PFO) and cryptogenic stroke are at risk of recurrence. Therapeutic regimens range from no treatment to anticoagulation treatment to surgical or interventional closure. However, long-term follow-up is only available for up to 4 years. METHODS: Among ~5,000 transesophageal echocardiographies in stroke/TIA-patients between 1988 and 1997, a PFO was found and considered a possible mediator for the neurological event in 97 patients. In these patients, the PFO was judged to be responsible for the neurological event. Patients with cardiac or other reasons for embolism were excluded. The therapy for stroke was chosen by the attending physician. Follow-up information was obtained through telephone interviews. RESULTS: Follow-up was available for 86 patients (89%) with a mean period of 15.4 years (range, 11.2-25.9 years). Thirteen patients (15%) suffered from recurrent ischemic events (7 TIAs, 5 strokes, 1 peripheral embolism) after a mean period of 4.9 years. Four patients died, not associated with recurrent thromboembolism. The risk of recurrence was increased over the entire length of the mean follow-up period. The occurrence of recurrent events was not associated with differences in baseline data, the presence of ASA, PFO size or the chosen treatment. CONCLUSION: In patients with paradoxical embolism, recurrent ischemic events are frequent despite medical therapy. These events are not limited to the early years after the index event; this long-term follow-up revealed a risk of occurrence over the entire follow-up. These patients have a sustained risk of recurrence, requiring lifetime protection, which should be considered in tailoring individual therapeutic strategies.


Subject(s)
Embolism, Paradoxical/epidemiology , Foramen Ovale, Patent/complications , Stroke/epidemiology , Thromboembolism/epidemiology , Adult , Echocardiography, Transesophageal , Female , Follow-Up Studies , Humans , Ischemic Attack, Transient/epidemiology , Ischemic Attack, Transient/etiology , Male , Middle Aged , Recurrence , Risk Factors , Stroke/etiology , Thromboembolism/etiology , Time Factors
7.
Int J Cardiol ; 151(3): 303-6, 2011 Sep 15.
Article in English | MEDLINE | ID: mdl-20598759

ABSTRACT

BACKGROUND: Chronic severe pulmonary regurgitation (PR) causes progressive right ventricular (RV) dysfunction and heart failure. Parameters defining the optimal time point for surgery of chronic PR are lacking. The present study prospectively evaluated the impact of preoperative clinical parameters, cardiorespiratory function, QRS duration and NT-proBNP levels on post operative RV function and volumes assessed by cardiac magnetic resonance imaging (CMR) in patients with chronic severe PR undergoing pulmonary valve replacement. METHODS AND RESULTS: CMR was performed pre- and 6 months postoperatively in 27 patients (23.6 ± 2.9 years, 15 women) with severe PR. Postoperatively, RV endsystolic (RVESVI) and enddiastolic volume indices (RVEDVI) decreased significantly (RVESVI pre 78.2 ± 20.4 ml/m² BSA vs. RVESVI post 52.2 ± 16.8 ml/m²BSA, p<0.001; RVEDVI pre 150.7 ± 27.7 ml/m²BSA vs. RVEDVI post 105.7 ± 26.7 ml/m²BSA; p<0,001). With increasing preoperative QRS-duration, postoperative RVEF decreased significantly (r=-0.57; p<0.005). Preoperative QRS-duration smaller than the median (156 ms) predicted an improved RVEF compared to QRS-duration≥ 156 ms (54.9% vs 46.8%, p<0.05). Multivariate analysis identified preoperative QRS duration as an independent predictor of postoperative RVEF (p<0.005). NT-proBNP levels correlated with changes in RVEDI (r=0.58 p<0,005) and RVESVI (r=0.63; p<0,0001). Multivariate analysis identified NT-proBNP levels prior to PVR as an independent predictor of volume changes (p<0.05). CONCLUSION: Valve replacement in severe pulmonary regurgitation causes significant reduction of RV volumes. Both, preoperative NT-proBNP level elevation and QRS prolongation indicate patients with poorer outcome regarding RV function and volumes.


Subject(s)
Heart Defects, Congenital/physiopathology , Heart Valve Prosthesis Implantation , Natriuretic Peptide, Brain , Peptide Fragments , Pulmonary Valve Insufficiency/physiopathology , Ventricular Function, Right/physiology , Adult , Chronic Disease , Electrocardiography , Female , Follow-Up Studies , Heart Defects, Congenital/blood , Heart Defects, Congenital/surgery , Heart Valve Prosthesis Implantation/adverse effects , Humans , Male , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Preoperative Care/methods , Prospective Studies , Pulmonary Valve/pathology , Pulmonary Valve/surgery , Pulmonary Valve Insufficiency/blood , Pulmonary Valve Insufficiency/surgery , Time Factors , Young Adult
8.
J Med Case Rep ; 4: 80, 2010 Mar 04.
Article in English | MEDLINE | ID: mdl-20202212

ABSTRACT

INTRODUCTION: Peripartum cardiomyopathy is a rare form of cardiomyopathy, with heterogeneous presentation occurring in women between one-month antepartum and six months postpartum. It carries a poor prognosis and a high risk of mortality. CASE PRESENTATION: We report the development of peripartum cardiomyopathy in two sisters, 27- and 35-year-old African women, one of whom presented with a large left ventricular thrombus. Subsequently, both patients were treated with bromocriptine, heparin and standard therapy for heart failure (angiotensin converting enzyme inhibitors, beta-blockers and diuretics). During follow-up, the left ventricular thrombus observed in one patient degraded. Neither patient experienced a thrombotic event, and both experienced continuous improvements in cardiac function and New York Heart Association stage. CONCLUSION: The development of peripartum cardiomyopathy in two sisters indicates that there may be a genetic basis for this type of cardiomyopathy, and that women with a positive family history for peripartum cardiomyopathy may have an increased risk of developing the disease. This is also the first report of a patient experiencing degradation of a large left ventricular thrombus under standard therapy for heart failure with bromocriptine. It suggests that the use of bromocriptine in association with adequate anti-coagulation and heart failure therapy may be beneficial and safe.

9.
Int J Cardiol ; 132(3): 375-81, 2009 Mar 06.
Article in English | MEDLINE | ID: mdl-18261811

ABSTRACT

BACKGROUND: The univentricular circulation after a Fontan procedure is characterized by an abnormal cardiorespiratory response being attributable to an inability to increase stroke volume during exercise. In congenital heart disease a broad QRS complex has been related to increased intracardiac volume and mass being associated with poor ventricular function and prognosis. OBJECTIVES: This study investigated the relation between the width of the QRS complex and parameters of cardiorespiratory response in adult patients after a Fontan procedure. METHODS: Clinical data and parameters of cardiorespiratory function of 56 patients (15 women, 41 men, mean age 23.7+/-6.4 years, mean age at operation 10.0+/-7.5 years) were related to the width of the QRS complex. RESULTS: In the whole group the mean QRS duration was 115+/-23 ms. A QRS complex >or= 120 ms was present in 23 patients. These patients were characterized by significantly older age at operation (13.0+/-9.3 versus 7.9+/-5.1; p<0.05). Compared to individuals with smaller QRS complexes they showed a decreased oxygen uptake (PeakVO(2): 21.6+/-5.2 versus 27.7+/-6.6 ml/kg/min; p<0.001), work rate (1.6+/-0.5 versus 2.0+/-0.5 W/kg, p<0.05), maximum blood pressure (p<0.001) and increase in blood pressure (p<0.05). Univariate analysis showed a significant correlation between PeakVO(2) and several other parameters of cardiorespiratory exercise testing (work rate,O(2)-pulse, increase in heart rate and blood pressure, maximum heart rate and blood pressure), maximum enddiastolic diameter of the systemic ventricle, age at operation. Multivariate regression analysis identified QRS duration as the only independent predictor of PeakVO(2) (p=0.05). CONCLUSION: In a Fontan circulation a broad QRS complex is a negative predictor of cardiorespiratory function. Early Fontan operation may be beneficial in terms of exercise capacity.


Subject(s)
Coronary Circulation/physiology , Fontan Procedure , Heart Conduction System/physiopathology , Adolescent , Adult , Blood Pressure , Exercise Test , Female , Heart Rate , Humans , Male , Middle Aged , Multivariate Analysis , Oxygen Consumption , Postoperative Period , Ventricular Function , Young Adult
10.
Dtsch Arztebl Int ; 105(44): 751-6, 2008 Oct.
Article in English | MEDLINE | ID: mdl-19623273

ABSTRACT

INTRODUCTION: Peri- or postpartum cardiomyopathy (PPCM) is a rare, life-threatening heart disease of unclear origin and is characterized by heart failure of sudden onset between the final weeks of pregnancy and 6 months after delivery. METHODS: Selective literature search in the databases of the National Center for Biotechnology Information based on the key words "peri- and postpartum cardiomyopathy," "pregnancy" and "heart failure" and additional information from the authors' personal experience. RESULTS: PPCM is often not diagnosed until late in its course, because its clinical manifestations are highly variable and a heart disease may not be suspected at first. Frequent presenting symptoms of PPCM, such as prostration, shortness of breath on mild exertion, and coughing, are often initially misinterpreted as evidence of pneumonia or as physiological accompaniments of pregnancy and delivery. The clinical picture of PPCM corresponds to a dilated cardiomyopathy (DCM) with signs of severe heart failure. Therefore, treatment with ACE inhibitors, diuretics, aldosterone antagonists, and beta-blockers is required. Recent research findings suggest a possible new approach to the treatment of PPCM with bromocriptine, which inhibits the release of prolactin, a lactation-promoting hormone. To date, only the treatment of heart failure in PPCM is evidence-based, while all other treatments are "level C," i.e., based on expert opinion only. CONCLUSION: The early diagnosis and interdisciplinary management of PPCM can often lead to substantial recovery from heart failure and cardiomyopathy.

11.
Vasc Health Risk Manag ; 3(5): 775-9, 2007.
Article in English | MEDLINE | ID: mdl-18078031

ABSTRACT

A 41 -year old female patient was admitted with acute onset of dyspnea and chest pain. Previous history revealed asthma, chronic sinusitis and eosinophilic proctitis. Electrocardiogram showed anterior ST-segment elevations and inferior ST-segment depression. Immediate heart catheterization revealed a distally occluded left anterior descending coronary artery, the occlusion being reversible after nitroglycerine. Cardiac magnetic resonance imaging was consistent with perimyocarditis. Hypereosinophilia and IgE elevation were present and Churg-strauss syndrome was diagnosed.


Subject(s)
Acute Coronary Syndrome/complications , Acute Coronary Syndrome/pathology , Churg-Strauss Syndrome/complications , Churg-Strauss Syndrome/pathology , Adult , Angiography , Churg-Strauss Syndrome/blood , Churg-Strauss Syndrome/enzymology , Creatine Kinase/blood , Eosinophils/cytology , Female , Follow-Up Studies , Humans , Leukocyte Count , Magnetic Resonance Imaging
13.
Eur J Echocardiogr ; 8(4): 298-302, 2007 Aug.
Article in English | MEDLINE | ID: mdl-16762597

ABSTRACT

We are presenting a case of floating left and right atrial formations on an atrial septal defect occluder system (23mm StarFLEX)-Occluder) initially supposed to be thrombotic appositions in a 57-year-old man. The closure was performed on the background of left hemispheric stroke and atrial septal aneurysm (ASA) with patent foramen ovale (PFO). The suspect structures were detected in the 6-month follow-up by transesophageal echocardiography (TEE). The patient underwent a successful surgical explantation of the closure device and closure of the patent foramen ovale (PFO) using a pericardial patch. The pathological evaluation of the biatrial device associated appositions revealed hytrophic heart muscle tissue with perifocal scarring and purulent abscess-forming, granulating and foam-cell including inflammatory foreign body reaction instead of the expected thrombus formation.


Subject(s)
Abscess/etiology , Cardiac Catheterization/adverse effects , Foreign Bodies/etiology , Heart Septal Defects, Atrial/therapy , Inflammation/etiology , Thrombosis/diagnostic imaging , Abscess/diagnostic imaging , Cardiac Catheterization/instrumentation , Cardiac Surgical Procedures , Foreign Bodies/diagnostic imaging , Heart Aneurysm/physiopathology , Humans , Inflammation/diagnostic imaging , Male , Middle Aged , Stroke/physiopathology , Thrombosis/etiology , Ultrasonography
14.
Eur J Echocardiogr ; 8(1): 53-6, 2007 Jan.
Article in English | MEDLINE | ID: mdl-16337834

ABSTRACT

We report on a case of a mobile left atrial thrombus formation on an atrial septal defect occluder system (28 mm StarFLEX-Occluder) despite 6 months of postprocedural anticoagulation with phenprocoumon and platelet antiaggregation with aspirin in a 69-year-old woman. The closure was performed because of a significant left to right atrial shunt (Qp/Qs 1.8) with enlargement of the right atrial and ventricular cavities and impairment of right ventricular function in the presence of persistent atrial fibrillation and chronic heart failure (NYHA II-III). The 6-month follow up by transoesophageal echocardiography (TEE) revealed the floating thrombus located at the left atrial side of the occluder.


Subject(s)
Balloon Occlusion/instrumentation , Embolization, Therapeutic/adverse effects , Heart Septal Defects, Atrial/surgery , Prostheses and Implants/adverse effects , Thromboembolism/etiology , Aged , Embolization, Therapeutic/instrumentation , Female , Heart Septal Defects, Atrial/diagnostic imaging , Humans , Thromboembolism/diagnostic imaging , Ultrasonography
15.
Int J Cardiol ; 114(2): E36-7, 2007 Jan 08.
Article in English | MEDLINE | ID: mdl-17067692

ABSTRACT

In women with Marfan syndrome pregnancy increases the risk of aortic dissection. There are a number of articles reporting the outcome of acute aortic dissection during pregnancy in this patient group. In contrast, only scarce information is available concerning pregnancy in patients with pre-existing chronic aortic dissection. We report the case of a pregnant Marfan syndrome patient with pre-existing chronic aortic dissection that showed a favourable maternal and fetal outcome.


Subject(s)
Aortic Dissection/complications , Marfan Syndrome/complications , Pregnancy Complications , Adult , Female , Humans , Pregnancy
16.
Echocardiography ; 22(8): 665-70, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16174120

ABSTRACT

BACKGROUND: Transthoracic echocardiography is the predominant diagnostic tool to evaluate systolic and diastolic cardiac function noninvasively in mice. It is known that systolic function is substantially influenced by anesthetic agents used for sedation during echocardiography. However, the effect on diastolic function has not been investigated yet. The following study was conducted to evaluate the influence of different agents on diastolic left ventricular function in mice. METHODS AND RESULTS: The effect of ketamine/xylazine (K/X), ketamine/midazolam (K/M), and tribromoethanol (TBE, Avertin) on diastolic function was measured 5, 15, and 25 minutes after the onset of anesthesia. Ratio of peak early-to-late myocardial diastolic velocities (Ea/Aa; determined by tissue Doppler imaging; TDI), ratio of peak transmitral early (E)- and late-diastolic velocity (E/A), deceleration time (DT), and isovolumic relaxation time (IVRT) correlated significantly with heart rate (HR). Overall, increasing HR contributed to a decrease of E/A-, Ea/Aa ratio, IVRT, and DT, whereas agents characterized by the strongest variation of HR (K/M and TBE) were associated with the greatest effect on diastolic function. CONCLUSION: Left ventricular diastolic function in mice, determined by echocardiography, is dependent on anesthetic agent and timing of measurements after onset of anesthesia.


Subject(s)
Anesthetics/administration & dosage , Diastole/physiology , Echocardiography/methods , Heart Ventricles/diagnostic imaging , Ventricular Function, Left/physiology , Ventricular Function , Animals , Diastole/drug effects , Heart Ventricles/drug effects , Injections, Intraperitoneal , Mice , Mice, Inbred C57BL , Severity of Illness Index , Ventricular Function, Left/drug effects
17.
Eur J Echocardiogr ; 6(5): 367-75, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16153558

ABSTRACT

AIM: The Pulsed Doppler Tei index is a parameter to evaluate combined systolic and diastolic function in humans. However, one major limitation is that the parameters of Pulsed Doppler Tei index cannot be measured within one cardiac cycle. Therefore, accuracy of the Pulsed Doppler Tei index may be affected by anesthesia induced heart rate variation in mice echocardiography. Tissue Doppler Imaging (TDI) enables us to measure both relaxation and contraction velocities simultaneously. Thus, the aim of our study was to validate TDI and Pulsed Doppler Tei index and their reproducibility in mice after experimental anterior myocardial infarction (MI). METHODS AND RESULTS: Pulsed Doppler Tei index and TDI Tei index were assessed before and 4 weeks after MI. Both parameters increased significantly after MI (Pulsed Doppler: 0.4+/-0.04 to 0.7+/-0.03; P<0.001; TDI: 0.2+/-0.03 to 0.5+/-0.04; P<0.0001). In addition, TDI Tei index showed a good correlation with ejection fraction and fractional shortening, and was indicated by better reproducibility than Pulsed Doppler Tei index. CONCLUSION: Tissue Doppler Tei index is appropriate to characterize global left ventricular function in mice after MI.


Subject(s)
Echocardiography, Doppler, Pulsed , Echocardiography, Doppler , Myocardial Infarction/diagnostic imaging , Myocardial Infarction/physiopathology , Ventricular Function, Left , Animals , Disease Models, Animal , Heart Rate , Hypertrophy, Left Ventricular/diagnostic imaging , Hypertrophy, Left Ventricular/physiopathology , Mice , Mice, Inbred C57BL , Predictive Value of Tests , Reproducibility of Results , Stroke Volume
18.
J Magn Reson Imaging ; 21(5): 604-10, 2005 May.
Article in English | MEDLINE | ID: mdl-15834905

ABSTRACT

PURPOSE: To evaluate the signal-to-noise ratio (SNR), precision, and accuracy of phase-contrast flow measurements at 3 T with the help of an in vitro model and to compare the results with data from two 1.5-T scanners. MATERIALS AND METHODS: Using an identical setup of a laminar flow model and sequence parameters, measurements were done at one 3-T and at two 1.5-T systems. Precision, accuracy, and SNR were obtained for velocity encodings ranging from 55 up to 550 cm(-1). SNRs were calculated from the magnitude as well as the flow encoded images. RESULTS: Precision and accuracy for the in vitro flow model were similarly high in all scanners with no significant difference. For velocity encodings from 55 cm(-1) up to 550 cm(-1), the SNR in magnitude as well as phase encoded images of the 3-T measurements was approximately 2.5 times higher than the SNR obtained from the two 1.5-T systems. CONCLUSION: Even without optimization for the 3-T environment, flow measurements show the same high accuracy and precision as is known from clinical 1.5-T scanners. The superior SNR at 3 T will allow further improvements in temporal and spatial resolution. This will be of interest for small-size vessels like coronary arteries or for slow diastolic flow patterns.


Subject(s)
Blood Flow Velocity/physiology , Magnetic Resonance Angiography/methods , In Vitro Techniques , Phantoms, Imaging , Reproducibility of Results
19.
Am J Cardiol ; 94(8): 1037-40, 2004 Oct 15.
Article in English | MEDLINE | ID: mdl-15476620

ABSTRACT

In this intravascular ultrasound study, the mechanism of restenosis after stenting in acute myocardial infarction (AMI) was investigated in 33 patients 6 months after primary coronary intervention for AMI. Restenosis after stenting for AMI was primarily caused by stent underexpansion, not by neointima formation.


Subject(s)
Coronary Restenosis/etiology , Myocardial Infarction/surgery , Postoperative Complications/etiology , Stents , Coronary Restenosis/diagnostic imaging , Female , Humans , Male , Middle Aged , Postoperative Complications/diagnostic imaging , Ultrasonography
20.
J Am Soc Echocardiogr ; 17(9): 954-61, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15337960

ABSTRACT

OBJECTIVE: This study was performed to validate noninvasive transthoracic Doppler ultrasound (TTD) with simultaneous invasive Doppler guidewire measurements in patients after minimal invasive direct coronary artery bypass operation. METHODS: A total of 14 patients were examined 3 to 8 days after minimal invasive direct coronary artery bypass operation. TTD was performed to measure systolic and diastolic peak velocities of the left internal mammary artery (LIMA) at rest and during adenosine-induced hyperemia. Simultaneous Doppler guidewire measurements were performed. RESULTS: LIMA flow was detected in 12 of 14 patients (86%). There was high agreement between TTD and Doppler guidewire measurements of LIMA flow velocities (systolic peak velocity: r = 0.86, y = 11.3 + 0.82x +/- 7.9; diastolic peak velocity: r = 0.95, y = 5.7 + 1.02x +/- 7.5; average peak velocity: r = 0.95, y = 5.2 + 0.94x +/- 5.4; and flow velocity reserve: r = 0.97, y = 5.2 + 0.99x +/- 4.5). CONCLUSION: TTD represents an accurate method to evaluate flow velocities and flow velocity reserve of LIMA bypass grafts even in the early phase after minimal invasive direct coronary artery bypass operation.


Subject(s)
Coronary Artery Bypass , Echocardiography, Doppler , Internal Mammary-Coronary Artery Anastomosis , Mammary Arteries/diagnostic imaging , Adult , Aged , Blood Flow Velocity , Female , Humans , Male , Mammary Arteries/surgery , Middle Aged , Minimally Invasive Surgical Procedures
SELECTION OF CITATIONS
SEARCH DETAIL
...