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1.
J Environ Radioact ; 80(3): 305-26, 2005.
Article in English | MEDLINE | ID: mdl-15725505

ABSTRACT

In preparation for verification of the Comprehensive Nuclear-Test-Ban-Treaty, automated radioxenon monitoring is performed in two distinctive environments: Ottawa and Tahiti. These sites are monitored with SPALAX (Systeme de Prelevement d'air Automatique en Ligne avec l'Analyse des radioXenons) technology, which automatically extracts radioxenon from the atmosphere and measures the activity concentrations of (131m,133m,133,135)Xe. The resulting isotopic concentrations can be useful to discern nuclear explosions from nuclear industry xenon emissions. Ambient radon background, which may adversely impact analyser sensitivity, is discussed. Upper concentration limits are reported for the apparently radioxenon free Tahiti environment. Ottawa has a complex radioxenon background due to proximity to nuclear reactors and medical isotope facilities. Meteorological models suggest that, depending on the wind direction, the radioxenon detected in Ottawa can be characteristic of the normal radioxenon background in the Eastern United States, Europe, and Japan or distinctive due to medical isotope production.


Subject(s)
Environment , Environmental Monitoring/methods , Nuclear Warfare , Radioactive Fallout/analysis , Air Movements , Automation , Ontario , Polynesia , Reference Values , Xenon Radioisotopes/analysis
2.
Radiat Prot Dosimetry ; 105(1-4): 55-60, 2003.
Article in English | MEDLINE | ID: mdl-14526927

ABSTRACT

The present investigation was undertaken by the Department of Health, Canada, to determine the most appropriate value to use for uranium gastrointestinal absorption (f1) in setting the guideline for drinking water. Fifty participants, free from medical problems, were recruited from two communities: a rural area where drinking water, supplied from drilled wells, contained elevated levels of uranium and an urban area where the water supplied by the municipal water system contained < 1 microg l(-1). Uranium intake through food, drinking water and other beverages was monitored using the duplicate diet approach. Intake and excretion were measured by inductively coupled plasma-mass spectrometry (ICP-MS) in samples collected concurrently from the same individuals over a 3 d period. The range of f1 values was between 0.001 and 0.06, with a median of 0.009. These values were independent of gender, age, duration of exposure, daily total uranium intake and allocation of intake between food and water. Consistent with the recommendation of ICRP Publication 69, 78% were below 0.02.


Subject(s)
Digestive System/metabolism , Feces/chemistry , Food Contamination, Radioactive/analysis , Radiometry/methods , Uranium/pharmacokinetics , Water Pollutants, Radioactive/pharmacokinetics , Water Pollutants, Radioactive/urine , Absorption , Administration, Oral , Adult , Age Factors , Aged , Body Burden , Canada , Female , Humans , Intestinal Absorption/physiology , Male , Metabolic Clearance Rate/physiology , Middle Aged , Radiation Dosage , Sex Factors , Uranium/administration & dosage , Uranium/analysis , Water Pollutants, Radioactive/analysis
3.
Health Phys ; 83(1): 35-45, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12075682

ABSTRACT

The gastrointestinal absorption factor (f1) for uranium in humans has been determined from a study of 50 volunteers, ingesting uranium at natural levels in drinking water and food. The purpose of the study was to find an appropriate f1 value for humans to use in deriving exposure guidelines for uranium. The participants ranged in age from 13 to 87 years. They were selected from two communities: New Ross, Nova Scotia with elevated uranium in drinking water, and Ottawa, Ontario with very low levels of uranium. Uranium intake and excretion were measured in samples collected concurrently from the same individuals over a three-day period. The duplicate diet method was used to monitor uranium intake in food and water. Uranium levels in all samples were measured by inductively coupled plasma mass spectrometry (ICP/MS). The distribution of f1 values obtained was non-Gaussian with a range of 0.001 to 0.06 and a median of 0.009. Seventy-eight percent of the subjects had values less than 0.02. These values are consistent with the recommendations of ICRP 69. The f1 values were not gender-sensitive and were independent of age at time of study, duration of exposure, and total uranium intake. The implications of these findings are discussed in terms of setting drinking water guidelines.


Subject(s)
Intestinal Absorption , Uranium/pharmacokinetics , Adolescent , Adult , Aged , Aged, 80 and over , Diet , Environmental Exposure , Food Analysis , Humans , Mass Spectrometry , Middle Aged , Nova Scotia , Ontario , Quality Assurance, Health Care , Reproducibility of Results , Uranium/analysis , Water Supply
4.
Toxicol Sci ; 43(1): 68-77, 1998 May.
Article in English | MEDLINE | ID: mdl-9629621

ABSTRACT

A study was conducted of the chemical effects on the human kidney induced by the chronic ingestion of uranium in drinking water. Subjects were divided into two groups: The low-exposure group, whose drinking water was obtained from a municipal water system and contained < 1 microgram uranium/L, and the high-exposure group, whose drinking water was obtained from private drilled wells and contained uranium levels that varied from 2 to 781 micrograms/L. Years of residence varied from 1 to 33 years in the low-exposure group and from 3 to 59 years in the high-exposure group. The indicators of kidney function measured in this study included glucose, creatinine, protein, and beta 2-microglobulin (BMG). The markers for cell toxicity studied were alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), and N-acetyl-beta-D-glucosaminidase (NAG). Urinary glucose was found to be significantly different and positively correlated with uranium intake for males, females, and pooled data. Increases in ALP and BMG were also observed to be correlated with uranium intake for pooled data. In contrast, the indicators for glomerular injury, creatinine and protein, were not significantly different between the two groups nor was their urinary excretion correlated to uranium intake. These results suggest that at the intakes observed in this study (0.004 microgram/kg to 9 micrograms/kg body wt), the chronic ingestion of uranium in drinking water affects kidney function and that the proximal tubule, rather than the glomerulus, is the site for this interference.


Subject(s)
Kidney/drug effects , Uranium/toxicity , Water Pollutants, Radioactive/toxicity , Adult , Aged , Biomarkers , Female , Humans , Kidney/physiopathology , Kidney Function Tests , Male , Middle Aged , Uranium/administration & dosage , Water Pollutants, Radioactive/administration & dosage , Water Supply
5.
Health Phys ; 71(2): 211-4, 1996 Aug.
Article in English | MEDLINE | ID: mdl-8690605

ABSTRACT

The Human Monitoring Laboratory, which acts as the Canadian National Calibration Reference Center for In Vivo monitoring, has constructed a robust neck-thyroid phantom for use in the Canadian Thyroid Intercomparison Program. The phantom is rugged and capable of being distributed through the mail with no expectation of a leak of radioactive materials; it is anthropomorphic; the thyroid inserts simulate 125I and 131I; the phantom can be used to mimic different layers of adipose tissue over the thyroid insert; and it is cost effective. This paper describes the design criteria and the manufacturing process; the performance characteristics have been described in an earlier publication.


Subject(s)
Neck , Phantoms, Imaging , Radiation Monitoring/instrumentation , Thyroid Gland , Canada , Humans , Iodine Radioisotopes/analysis , Postal Service
6.
Health Phys ; 70(3): 418-24, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8609036

ABSTRACT

High level contamination was observed on two workers during a routine hand check of personnel leaving a laboratory where barium carbonate labeled with 14C was handled. A third worker was found to have been exposed to airborne 14C (carbonate) aerosol during the investigation. Urinary excretion analysis and in vivo monitoring were carried out. This paper presents the results of more than one year of lung counting using phoswich detectors and gives some indication about the metabolism of the 14C over that period. Doses were difficult to estimate due to lack of information in the literature. Estimates were based on default parameters and information gathered in this study using ICRP 30 and the new ICRP lung models. These ranged from 0.3 mSv to 3 mSv depending on the assumptions and models.


Subject(s)
Carbon Radioisotopes/adverse effects , Carbon Radioisotopes/analysis , Radioactive Hazard Release , Radiometry , Barium , Body Burden , Carbon Radioisotopes/pharmacokinetics , Carbonates , Humans , Lung/metabolism , Lung/radiation effects , Models, Biological , Occupational Exposure , Radiation Dosage , Radiation Monitoring , Radiation Protection , Urine/chemistry
7.
Health Phys ; 70(3): 425-9, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8609037

ABSTRACT

The Human Monitoring Laboratory, which acts as the Canadian National Calibration Reference Centre for In Vivo Monitoring, has determined the performance characteristics of four thyroid phantoms for 125I thyroid monitoring. The phantoms were a phantom built to the specifications of the American National Standards Institute Standard N44.3; the phantom available from Radiology Support Devices; the phantom available from Kyoto Kagaku Hyohon; the phantom manufactured by the Human Monitoring Laboratory and known as the BRMD phantom. The counting efficiencies of the phantoms for 125I were measured at different phantom-to-detector distances. The anthropomorphic characteristics of the phantoms have been compared with the average man parameters. It was concluded that the BRMD, American National Standards Institute, and Radiology Support Devices phantoms have the same performance characteristics when the neck-to-detector distances are greater than 12 cm and all phantoms are essentially equivalent at 30 cm or more. The Kyoto Kagaku Hyohon phantom showed lower counting efficiencies at phantom-to-detector distances less than 30 cm. This was attributed to the design of the phantom. This study has also shown that the phantom need not be highly anthropomorphic provided the calibration is not performed at short neck-detector distances. Indeed, it might be possible to use t simple point source of 125I placed behind a 1.5 cm block of lucite at neck detector distances of 12 cm or more.


Subject(s)
Iodine Radioisotopes/analysis , Neck/anatomy & histology , Phantoms, Imaging , Radiation Monitoring , Thyroid Gland/anatomy & histology , Thyroid Gland/radiation effects , Adolescent , Adult , Evaluation Studies as Topic , Female , Humans , Iodine Radioisotopes/adverse effects , Male
8.
Can J Med Radiat Technol ; 25(4): 125-8, 1994 Oct.
Article in English | MEDLINE | ID: mdl-10137671

ABSTRACT

This article is the last of a five-part series covering various aspects of occupational thyroid monitoring. This part describes the techniques for minimizing errors due to improper placement of the detector. The impact of counting time and minimum detectable activity as a function of detector position are also discussed. The importance of minimum detectable activity is exemplified by showing how it can be used to ensure that the thyroid monitoring system can detect an amount of radioactivity below the derived investigation level.


Subject(s)
Occupational Health , Radiation Monitoring/standards , Thyroid Gland/radiation effects , Calibration , Canada , Humans , Models, Statistical , Workplace
9.
Can J Med Radiat Technol ; 25(3): 100-3 contd, 1994 Aug.
Article in English | MEDLINE | ID: mdl-10136920

ABSTRACT

This article is the fourth of a five-part series covering various aspects of occupational thyroid monitoring. This article describes the energy calibration of the monitoring system with particular emphasis on techniques for optimizing a system that is based on a single-channel analyzer, or any system that does not have a multi-channel analyzer. These systems cannot directly show the operator the photopeak of the calibration source. The article also briefly discusses quality control and problem solving.


Subject(s)
Calibration/standards , Film Dosimetry/standards , Occupational Exposure/analysis , Radiation Monitoring/standards , Thyroid Gland/radiation effects , Canada , Health Personnel , Humans , National Health Programs , Radiology Department, Hospital/standards , Reference Standards
10.
Can J Med Radiat Technol ; 25(2): 61-3, 1994 May.
Article in English | MEDLINE | ID: mdl-10134385

ABSTRACT

This article is the third of a five-part series covering various aspects of occupational thyroid monitoring. This article introduces the basic concepts required to understand the procedure for determining the counting efficiency of a thyroid detector. The B.R.M.D. thyroid-neck phantom is used as the calibration source. A procedure for personnel monitoring is also discussed and the concept of Minimum Detectable Activity (MDA) is introduced. The last two articles in this series discuss energy calibration, counting system optimization based on a single-channel analyzer and placement error minimization.


Subject(s)
Calibration/standards , Film Dosimetry/standards , Occupational Exposure/analysis , Radiation Monitoring/standards , Thyroid Gland/radiation effects , Canada , Film Dosimetry/instrumentation , Guidelines as Topic , Health Personnel , Humans , National Health Programs , Radiation Monitoring/instrumentation , Radiology Department, Hospital/standards
11.
Can J Med Radiat Technol ; 25(1): 21-4, 1994 Mar.
Article in English | MEDLINE | ID: mdl-10168099

ABSTRACT

This article, the second of a five-part series covering various aspects of occupational thyroid monitoring, addresses the sources of error that can affect the final result obtained from thyroid monitoring, such as geometry effects (thyroid size, thyroid depth, precision and accuracy of the detector placement, and neck-detector distance). The article also suggests ways in which these errors can be minimized and identifies those errors that are difficult to quantify.


Subject(s)
Calibration/standards , Film Dosimetry/standards , Health Personnel , Occupational Exposure , Radiation Monitoring/standards , Thyroid Gland/radiation effects , Adult , Aged , Canada , Data Collection , Female , Humans , Male , Middle Aged , National Health Programs , Occupational Exposure/prevention & control , Quality Control , Radiology Department, Hospital/standards , Reference Standards
12.
Can J Med Radiat Technol ; 24(4): 157-60, 1993 Oct.
Article in English | MEDLINE | ID: mdl-10130372

ABSTRACT

This article is the first part of a five-part series covering various aspects of occupational thyroid monitoring. The Canadian National Calibration Reference Centre for In-Vivo Monitoring conducts a thyroid inter-comparison programme that now includes more than 100 facilities. The scope of the programme, begun in 1988, has greatly expanded in the last two years following a considerable effort to locate and inform facilities. This article presents the details of the programme, its results, and the lessons learned. Subsequent articles will discuss sources of errors, methodology, instrumental configuration, and counting geometry optimization.


Subject(s)
Calibration/standards , Film Dosimetry/standards , Health Personnel , Occupational Exposure , Radiation Monitoring/standards , Thyroid Gland/radiation effects , Canada , Data Collection , Humans , National Health Programs , Occupational Exposure/prevention & control , Program Development , Radiology Department, Hospital/standards , Reference Standards
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