ABSTRACT
In this study, poly(HEMA-PEGxMEM-IA) hydrogels were prepared by radical copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGxMEM), 2-hydroxyethyl methacrylate (HEMA), and itaconic acid (IA). The reaction was carried out in ethanolic solution using N,N'-methylenebisacrylamide (MBA) as a crosslinking agent and 1-hydroxycyclohexyl phenyl ketone (HCPK) as a photo-initiator. The poly(HEMA-PEGxMEM-IA) hydrogels (HGx) were evaluated as a delivery system for ursolic acid (UA), a phytochemical extracted from the plant Clinopodium revolutum, "flor de arena". The hydrogels were characterized by Fourier-transform infrared spectroscopy (FTIR-ATR), Raman spectroscopy, X-Ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The swelling behavior was studied in buffer solutions from pH 2 to 10, specifically at pH 2.2 (gastric environment) and 7.4 (intestinal environment). It was found that the hydrogels studied showed sensitivity to pH. At pH 2.2, the degree of swelling for HG5 and HG9 hydrogels was 0.45 and 0.93 (g water/g hydrogel), respectively. At pH 7.4, the degree of swelling for HG5 and HG9 hydrogels was 1.97 and 2.64 (g water/g hydrogel), respectively. The SEM images show the variation in pore size as a function of pH, and the UA crystals in the pores of the hydrogels can also be observed. The in vitro UA release data best fit the Korsmeyer-Peppas kinetic model and the diffusion exponent indicates that the release mechanism is governed by Fickian diffusion.
ABSTRACT
In the present study, Fe3O4/poly(2-hydroxyethyl methacrylate-co-itaconic acid) magnetic hydrogels (MHGs) were prepared by in situ synthesis of Fe3O4 magnetic particles in hydrogels (HGs). The resulting magnetic hydrogels were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), a vibrating sample magnetometer (VSM), scanning electron microscopy (SEM), and N2 adsorption-desorption. The effect of Fe3O4 on the swelling behavior and adsorption of methylene blue (MB) dye of the prepared hydrogel was studied. Parameters such as the dose, pH, contact time, and MB initial concentration were investigated. The results show that 75% (HG) and 91% (MHG) of MB (200 mg/L) were removed at doses of 2 mg/mL and 1 mg/mL, respectively, under a pH of 6.8 and a contact time of 10 min. The adsorption behavior followed the Langmuir isotherm model, indicating that the adsorption process takes place in monolayers and on homogeneous surfaces. The Langmuir capacities for MB adsorption using the HGs and MHGs were 78 and 174 mg/g, respectively. The adsorption kinetics followed a pseudo-second-order kinetic model. In addition, thermodynamic studies carried out show that the adsorption process is spontaneous and endothermic. Adsorption-desorption studies indicate that the magnetic hydrogel can remove MB for four cycles with removal efficiencies above 90%. Therefore, a MHG is suitable as an alternative material for MB adsorption.