[Physiologically adequate experimental model of aggression and emotional stress]. / Fiziologicheski adekvatnaia éksperimental'naia model' agressii i émotsional'nogo stressa.

A simple adequate experimental model of aggression and emotional stress has been elaborated, based on mild fixation of rats tails in the cage wall. It is shown that in a group of rats, in these conditions a continuous aggressive behaviour arises, leading to the development of emotional stress. The elaborated experimental model has no defects, characteristic of other models of aggression and stress. It demands neither a prolonged training of animals nor special expensive equipment; it allows simultaneous use in experiments of a great number of animals, creates conditions for natural aggressive-defensive behaviour of rats without provoking artificial manipulations. The proposed model allows to study the pathogenesis of emotional stress, mechanisms of resistivity and predisposition to it and also search and testing of biologically active substances, enhancing resistance to emotional stress.

[Effect of substance P on catecholamine levels in the hypothalamus and midbrain in the rat during immobilization stress]. / Vliianie substantsii P na uroven' katekholaminov v gipotalamuse i srednem mozge u krys pri immobilizatsionnom stresse.

Single intraperitoneal injection of substance P in a dose of 125 mcg/kg induced a significant increase of noradrenaline and dopamine level in the hypothalamus and the midbrain of intact rats. Under conditions of immobilization emotional stress, the substance P eliminated the stress induced decrease of hypothalamic noradrenaline and increase of its level in the midbrain; in other words the substance P normalized the noradrenaline level. Modulatory effect of a single injection of the substance P had a long-term character and was synchronized with an earlier found increase of resistability of rats to chronic emotional stress.

[Effect of several psychopharmacologic preparations on adaptation to stressful conditions]. / Vliianie nekotorykh psikhofarmakolegicheskikh preparatov na adaptatsiiu v usloviiakh stressa

Experiments staged on rats demonstrated that the formation of pathological states caused by stress and accompained by the development of ulcerative lesion of the gastric mucosa are associated with the degree of the catecholamines level drop in the mesencephalon and hypothalamus. The application of seduxen and also of combinations consisting of L-DOPA with seduxen, or with an L-adrenoblocking agent-pyroxan tends to reduce the frequency of developing ulcerative lesions of the stomach. The protective effect produced by the combination of L-DOPA with an L-adrenoblocking agent--pyroxan is barred by an additional administration of an beta-adrenoblocking agent--inderal.