1.
Org Lett
; 17(5): 1090-3, 2015 Mar 06.
Article
in English
| MEDLINE
| ID: mdl-25675098
ABSTRACT
A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,ß-unsaturated ketones with α-fluoro-ß-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.