ABSTRACT
BACKGROUND: The prosthetic repair of incisional hernias drastically reduced the incidence of recurrence, but increased the associated morbidity. We report a consecutive series of patients with incisional hernias operated by Rives- Stoppa procedure. The aim is to identify the early and late complications associated with the procedure. MATERIAL AND METHODS: 275 patients admitted and operated on between 2002-2006 were prospectively evaluated by direct examination and questionnaire. RESULTS: 171 responded in 2007 and 148 in 2009; direct examination was obtained 143 and 118 patients respectively.Recurrence rate 6.7%. Good and very good comfort rates in 58%. CONCLUSIONS: Similar results with the expert centre.
Subject(s)
Hernia, Ventral/surgery , Quality of Life , Surgical Mesh , Adult , Aged , Female , Follow-Up Studies , Hernia, Ventral/etiology , Humans , Male , Middle Aged , Prospective Studies , Recurrence , Surgical Mesh/adverse effects , Surveys and Questionnaires , Time Factors , Treatment Outcome , Wound HealingABSTRACT
Cardiopulmonary bypass (CPB) devices replace transiently the function of both heart and lungs, allowing the investigator to work safely on a stopped heart. Although this technology has greatly improved since its first applications in the early 1950's there is still no definitive rat CPB model, various experiments reporting drawbacks like pulmonary edema, large priming volumes,etc. We present a new oxygenator that can be used in cardiopulmonary bypass experiments in rats, simple in design and efficient in function,in which the process of blood oxygenation takes place in a vertical cylinder filled up with air or oxygen, with blood being spread onto the wall and then trickling down in a thin layer that facilitates the oxygen transfer. The oxygenation is efficient, the pO2 reaches levels of almost 150 mmHg (physiological level is around 100 mmHg) in conditions of oxygen saturation of over 99% (normal levels 95%-98%).
Subject(s)
Cardiopulmonary Bypass , Oxygenators , Animals , Blood Pressure/physiology , Carbon Dioxide/blood , Cardiopulmonary Bypass/instrumentation , Cardiopulmonary Bypass/methods , Electronics, Medical/instrumentation , Equipment Contamination/prevention & control , Equipment Design , Equipment Reuse , Hemoglobins/analysis , Hemolysis/physiology , Models, Animal , Oxygen/blood , Rats , Rats, Inbred BN , Rats, Sprague-Dawley , Sterilization , Time FactorsABSTRACT
The second part of the review presents the main facts and problems with respect to the role of cell death in teratogenesis (pathogenetic cell death). After mentioning the first approaches to the domain, reference is made (in order to avoid repetition) to the synthetic article published by Menkes et al. (1970), as to a series of investigations and results up to that date. Subsequently, more recent contributions are presented, first of all a series of results obtained in the Laboratory of Embryology and Teratology, Timiscara. The genetic background and the morphology of pathogenetic cell death are briefly discussed. As a conclusion, the scheme (published in 1970) of cell death linked teratogenesis is reproduced in a somewhat modified and extended way.
Subject(s)
Cell Death/physiology , Congenital Abnormalities/physiopathology , Embryonic and Fetal Development/physiology , Animals , Humans , Reference ValuesABSTRACT
This first part of the review deals with the main facts and problems related to the role of cell death in normal prenatal development. After an overview of the pioneering work in this field, the essential contributions brought during the last few decades are presented, with special stress upon the contribution brought by the team of the Laboratory of Embryology and Teratology, Timisoara. The morphology of cell death is analysed based upon the classification of Schweichel and Merker (1973). Finally, a detailed account is given on the recent, impressive advance with respect to molecular and molecular-genetic mechanisms underlying and determining the cell death process.
