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1.
2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents.
Haviv, F; DeNet, R W; Michaels, R J; Ratajczyk, J D; Carter, G W; Young, P R.
J Med Chem ; 26(2): 218-22, 1983 Feb.
Article in English | MEDLINE | ID: mdl-6827539

ABSTRACT

2-[(Phenylthio)methyl]pyridine derivatives inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat. In the same model, indomethacin was inactive, and hydrocortisone was active. Compounds Ia-d also significantly reduced exudate volume and white blood cell accumulation in the pleural RPAR. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin.


Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Pyridines/chemical synthesis , Animals , Biological Assay , Carrageenan , Hydrocortisone/pharmacology , Indomethacin/pharmacology , Leukocytes/drug effects , Male , Pleura/drug effects , Pyridines/pharmacology , Rats , Rats, Inbred Strains , Skin/drug effects
2.
New azacannabinoids highly active in the central nervous system.
Lee, C M; Zaugg, H E; Michaels, R J; Dren, A T; Plotnikoff, N P; Young, P R.
J Med Chem ; 26(2): 278-80, 1983 Feb.
Article in English | MEDLINE | ID: mdl-6681843

Subject(s)
Cannabinoids/chemical synthesis , Central Nervous System/drug effects , Aggression/drug effects , Animals , Aza Compounds/chemical synthesis , Aza Compounds/pharmacology , Behavior, Animal/drug effects , Cannabinoids/pharmacology , Drug Antagonism , Humans , Indicators and Reagents , Magnetic Resonance Spectroscopy , Methamphetamine/pharmacology , Mice , Motor Activity/drug effects , Rats , Serotonin/pharmacology , Structure-Activity Relationship
3.
Bureaucrats, legislators, and the decline of the state mental hospital.
Michaels, R J.
J Econ Bus ; 32(3): 198-205, 1980.
Article in English | MEDLINE | ID: mdl-10246895

Subject(s)
Budgets , Financial Management , Hospitals, Psychiatric/statistics & numerical data , Hospitals, Public/statistics & numerical data , Hospitals, State/statistics & numerical data , Length of Stay , Economics, Hospital , Models, Theoretical , Politics , United States
4.
Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives.
Lee, C M; Michaels, R J; Zaugg, H E; Dren, A T; Plotnikoff, N P; Young, P R.
J Med Chem ; 20(11): 1508-11, 1977 Nov.
Article in English | MEDLINE | ID: mdl-915915

Subject(s)
Behavior, Animal/drug effects , Cannabinoids/chemical synthesis , Pyridines/chemical synthesis , Analgesics/chemical synthesis , Animals , Antidepressive Agents/chemical synthesis , Benzopyrans/chemical synthesis , Benzopyrans/pharmacology , Cannabinoids/pharmacology , Dogs , Hypnotics and Sedatives/chemical synthesis , Mice , Motor Activity/drug effects , Pyridines/pharmacology , Rats , Tranquilizing Agents/chemical synthesis
5.
Synthesis and antidepressant activity of 5-phenyl-2-(2-propynylamino)-2-oxazolin-4-one and derivatives.
Lee, C M; Horrom, B W; Michaels, R J; Rasmussen, R M; Plotnikoff, N P.
J Med Chem ; 15(12): 1252-5, 1972 Dec.
Article in English | MEDLINE | ID: mdl-4635969

Subject(s)
Antidepressive Agents/chemical synthesis , Pemoline/chemical synthesis , Administration, Oral , Alkynes/administration & dosage , Alkynes/chemical synthesis , Alkynes/pharmacology , Alkynes/toxicity , Animals , Antidepressive Agents/administration & dosage , Antidepressive Agents/pharmacology , Antidepressive Agents/toxicity , Behavior, Animal/drug effects , Brain Chemistry/drug effects , Dihydroxyphenylalanine/pharmacology , Dopamine/analysis , Drug Synergism , Lethal Dose 50 , Mice , Norepinephrine/analysis , Pemoline/administration & dosage , Pemoline/pharmacology , Pemoline/toxicity , Serotonin/analysis , Structure-Activity Relationship
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