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Chem Commun (Camb)
; 59(6): 784-787, 2023 Jan 17.
Article
in English
| MEDLINE
| ID: mdl-36562323
ABSTRACT
A telescoped three-step sequence to functionalised spirocyclic oxetanes is reported, involving Paternò-Büchi reactions between maleic acid derivatives and cyclic ketones. p-Xylene suppresses the competing alkene dimerization that has plagued previous work, allowing access to 35 novel spirocyclic oxetanes that cannot be prepared using existing methodologies, and which represent versatile intermediates for further elaboration.