1.
Eur J Med Chem
; 35(9): 805-13, 2000 Sep.
Article
in English
| MEDLINE
| ID: mdl-11006482
ABSTRACT
Gossypol, gossypolone, reduced gossypol and new Schiff's bases of racemic gossypol and gossypolone were extracted or synthesized. Their cytotoxic activities on KB human cancer cells were determined. Gossypolone and the ethylamine derivative of gossypolone were the most active compounds (IC(50) in the micromolar range in both cases). The cytotoxicity of gossypol and gossypolone was increased when the tests were performed in the absence of serum and decreased when catalase as well as mannitol were added to the culture medium.
Subject(s)
Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/pharmacology , Gossypol/chemistry , Gossypol/pharmacology , Antineoplastic Agents/chemistry , Catalase/pharmacology , Cell Division/drug effects , Culture Media, Serum-Free , Drug Screening Assays, Antitumor , Free Radical Scavengers/pharmacology , Gossypol/analogs & derivatives , Humans , Mannitol/pharmacology , Structure-Activity Relationship , Tumor Cells, Cultured
2.
Mol Pharmacol
; 13(2): 368-73, 1977 Mar.
Article
in English
| MEDLINE
| ID: mdl-558504
Subject(s)
Dopamine/metabolism , Homocysteine/analogs & derivatives , Neuroblastoma/metabolism , S-Adenosylhomocysteine/analogs & derivatives , S-Adenosylhomocysteine/pharmacology , Animals , Catechol O-Methyltransferase/metabolism , Catechol O-Methyltransferase Inhibitors , Cells, Cultured , Methylation , Mice , Neuroblastoma/enzymology
3.
Anal Biochem
; 76(l): 330-41, 1976 Nov.
Article
in English
| MEDLINE
| ID: mdl-998970
