[The correction of lipid metabolism and microcirculation disturbances in early atherogenesis stages by thyroxine].

Thyroxine (T4) inhibits the development of lipid metabolism disorders and experimental atherosclerosis in rabbits (model N.N. Anichkov). The study of the hypothalamic-pituitary system, thyroid, and the microvascular bed also revealed a beneficial effect of thyroxine on their morpho-functional state. Thus, the role of neuroendocrine regulation and disorders of microcirculation in atherogenesis shown.

[Correction of autoimmune mechanisms underlying the development of type I diabetes mellitus by methods of cell therapy].

The modern concept of development of autoimmune diabetes mellitus is considered. The authors discuss possibilities to correct immune disturbances and support?--cells regeneration by therapy with the use of donor pancreatic cells, bone marrow cells (hemopoietic and stromal) and umbilical cord blood cells.

[Cellular reaction of the skin and underlying tissues on prolonged acupuncture needle introduction].

The changes of a skin and hypodermic are studied at the prolonged introduction (till 3 months) original acupuncture needles under a skin of an auricle and neck at rats by the technique Muhina M.M. In early terms in an introduction place develops an aseptic (or septic) inflammation reaching of peak in 1-2 weeks. On a measure reduction of inflammatory reaction activation of epydermis (keratinocites) which acquire from periphery an acupuncture needle is marked, isolating it from surrounding tissues and forming the implant channel (acustract). Formation process of acustract comes to the end through 2 - 2,5 months.

[Influence of cell therapy and alimentary correction on the condition of microcirculatory system in experimental dyslipidemia].

A comparative analysis of the impact of cell therapy (allogenic fetal liver cells, stem cells of autologic bone marrow) on lipid homeostasis, microcirculatory disturbances and structural changes in some organs was made using the atherosclerosis model in guinea-pigs. A positive effect of cell therapy on these parameters was established. The effect was stronger and prolonged after transplantation of stem cells. Atherogenic diet weakens the effect of cell therapy. Thus, cell therapy is more effective in restriction of atherogenic risk factors.

[Effect of perftoran on microcirculation and target organs in early atherogenesis]. / Vliianie perftorana na mikrotsirkuliatsiiu i organy-misheni na rannikh stadiiakh aterogeneza.

Effects of perfluoran, a plasma substitute with a gas-transport function, were studied at the stage of dyslipidogenic microangiopathy in rabbits. Changes in microcirculation, hemorheology, morphology of the liver, phospholipid composition of hepatocytic membranes were examined histologically, histochemically, electron microscopically and biochemically. Perfluoran produced a positive effect on microcirculation, phospholipid composition of hepatocytic membranes. Individual features of these parameters' dynamics were determined for animals.

[The correction of the pathological changes in the neuroendocrine system in hyperlipoproteinogenic microangiopathy]. / Korrektsiia patologicheskikh izmenenii v neiroéndokrinnoi sisteme pri giperlipoproteidogennoi mikroangiopatii.

Thymalin and alpha-tocopherol were studied for their effects on the morphofunctional status of the hypothalamopituitary neurosecretory system, thyroid, and adrenals in early atherogenesis. Correction of abnormal changes in the neuroendocrine organs restored lipid hemostasis, lowered the rate of lipid peroxidation, and prevented the progression of atherosclerotic changes in the great arteries.

[Synthetic antioxidant correction for disorders of the regulatory and microcirculatory systems in the early stages of experimental atherosclerosis]. / Korrektsiia sinteticheskimi antioksidantami narushenii v reguliatornoi i mikrotsirkuliatornoi sistemakh na rannikh stadiiakh éksperimental'nogo ateroskleroza.

The influence of synthetic antioxidants (AOs) on hypothalamo-hypophyseal neuro-secretory system (HHNS), sympatho-adrenal system and microcirculatory bad in early stages of atherogenesis in rabbits (Anichkov's model) was studied. Correction of lipid metabolism and lipid peroxidation (LP) activation by AOs was accompanied by disappearing of structural changes in regulatory and microcirculatory systems, regression of atheromatosis in great arteries. Stabilization effect of AOs on neurons and erythrocytes membrane structures was noticed. Some distinctions in mechanism of action between mexidol and fenbutol were found. Thus, regulatory and microcirculatory disturbances, which appear on early atherogenesis stages and is the basis of chronic noninfectious pathology in different target-organs is reversible, for example trough LP correction.

[The effect of a 3-hydroxypyridine-class antioxidant on disorders of the microcirculatory system in experimental dyslipoproteinemia and its alimentary correction]. / Vliianie antioksidanta iz klassa 3-oksipiridina na narusheniia v mikrotsirkuliatornoi sisteme pri éksperimental'noi dislipoproteidemii i ee alimentarnoi korrektsii.

The effect of antioxidant (AO) of the 3-hydroxypyridin class on microcirculatory system (MC) disorders of rabbits with dyslipoproteinemia (DLP) and its alimentary correction (the standard ration--9 months) was studied. Aorta, the intestinal mesentery microcirculatory bed, the microvessels adrenergic innervation, erythrocyte morphology were examined. The various lipoprotein fractions and lipid peroxidation (LP) products were studied in venous blood. After AO including into atherogenic diet (ATD) the lipid homeostasis disorders, the LP activation, MC disturbances, anomalous erythrocyte form appearance and atherosclerosis changes in aorta were less pronounced. Under the AO influence when DLP was corrected the initial level of lipid metabolism and LP restored, the MC disorders and the atherosclerosis changes in aorta regressed in a shorter period of time. The interrelation was observed between the DLP level, the structural and functional MC disorders and the extent of aorta atherosclerosis. Thus, DLP and LP correction at the early stages of pathological process can lead to the disappearance of MC disorders, what seems important for the prevention of atherosclerosis. The role of the LP activation in MC disorders in DLP and mexidol effect on them, especially in complex with DLP correction were evaluated.

[The mechanism of the disorder in the cytoarchitectonics and structural organization of the erythrocyte membranes in gestoses]. / Mekhanizm narusheniia tsitoarkhitektoniki i strukturnoi organizatsii éritrotsitarnykh membran pri gestozakh.

Mechanisms underlying gestosis-associated changes in architectonics of the erythrocytes and structural pattern of their membranes have been identified. The changes were related to the rates of lipid peroxidation in the erythrocyte membranes. Phospholipase A2 activation and tissue hypoxia were identified as important determinants of cell membrane abnormalities in progressive and moderate-to-severe nephropathy.

[Function of the microcirculatory system during the long-term regression of the early stages of atherogenesis]. / Sostoianie sistemy mikrotsirkuliatsii pri dlitel'noi regressii rannikh stadii aterogeneza.

Lipid metabolism, intestinal mesentery microcirculatory bed (MCB) and erythrocyte (E) morphology in arterial and venous blood were studied in rabbits with experimental atherosclerosis (the model of N. N. Anichkov) and its spontaneous regression. The interrelation was determined between lipid metabolism (LM), MCB structural and functional disorders and anomalous E form appearance, and to a lesser extent the atheromatosis of the aorta. Microcirculatory (MC) disorders disappeared 12 months later in the regression of the early stages of atherogenesis (after 2 months of diet). The generalized character of MC disorders in LM suggests the existence of a trend towards MC reconstitution in prolonged regression in different organs and tissues. Thus, LM correction at the early stages of the pathological process can be accompanied by the disappearance of MC disorders, which seems important for the prevention of atherosclerosis.

[Morphological, cytochemical and radioautographic analysis of the development of a population of mitral cells of the rat olfactory bulb in prenatal ontogeny]. / Morfologicheskii, tsitokhimicheskii i radioavtograficheskii analiz razvitiia populiatsii mitral'nykh kletok oboniatel'noi lukovitsy mozga krys v prenatal'nom ontogeneze.

The dynamics of DNA synthesis, its ratio to the proliferative activity and changes in the amount of genetic material in mitral cells of the white rat olfactory bulb during prenatal ontogenesis, as well as in newborn rats are considered. The lengthening of G2-phase, decrease of mitotic activity and increase of DNA content in the nuclei of forming mitral cells were shown to occur in the period from 18 till 20 days of embryogenesis.