Evidence of alliesthesia during a neighborhood thermal walk in a hot and dry city.

Designing cities for thermal comfort is an important priority in a warming and urbanizing world. As temperatures in cities continue to break extreme heat records, it is necessary to develop and test new approaches capable of tracking human thermal sensations influenced by microclimate conditions, complex urban geometries, and individual characteristics in dynamic settings. Thermal walks are a promising novel research method to address this gap. During a thermal walk in Phoenix, Arizona, USA, we examined relationships between the built environment, microclimate, and subjective thermal judgments across a downtown city neighborhood slated for redevelopment. Subjects equipped with GPS devices participated in a 1-hour walk on a hot sunny day and recorded their experience in a field guide. Microclimate measurements were simultaneously collected using the mobile human-biometeorological instrument platform MaRTy. Results revealed significant differences in physiologically equivalent temperature (PET) and modified physiologically equivalent temperature (mPET) and between street segments with more than 18 °C (25 °C mPET) between the maximum and minimum values. Wider range of mPET values reflected the inclusion of individual level data into the model. Streets with higher sky view factor (SVF) and east-west orientation showed a higher PET and mPET overall. Furthermore, we showed evidence of thermal alliesthesia, the pleasure resulting from slight changes in microclimate conditions. Participants' sense of pleasure was related to the mean PET of the segment they just walked, with linear regression explaining over 60% of the variability. We also showed that estimated percent shade was significantly correlated with SVF, PET, mPET, and pleasure, indicating that participants could sense minor changes in microclimate and perceived shade as pleasant. Although generalization of results is limited by a low sample size, findings of this study improve the understanding of dynamic thermal comfort in complex urban environments and highlight the value of thermal walks as a robust research method.

[Antibiotic prophylaxis and immune-compromised patients]. / AB-profylaxe en immuungecompromitteerde patiënten.

On the basis of the arguments found in the literature for and against prescribing antibiotic prophylaxis for dental procedures in immunecompromised patients, dental care providers are advised not to prescribe antibiotic prophylaxis to this group of patients when they undergo dental treatment, unless it concerns an exceptional case. Such cases comprise immune-compromised patients considered to have a high risk of developing systemic infections when undergoing invasive dental procedures, including extractions or implant placement. These are patients with, for example, severe neutropenia, patients with a primary immune deficiency, or patients who use high doses of immunosuppressants or very strong immunosuppressants. There is little evidence in the literature about the use of antibiotic prophylaxis for this specific group of patients. Such evidence is, however, also difficult to obtain because it concerns a small group of patients.

The mesoderm specification factor twist in the life cycle of jellyfish.

The basic helix-loop-helix (bHLH) transcription factor Twist is highly conserved from Drosophila to vertebrates and plays a major role in mesoderm specification of triploblasts. The presence of a Twist homologue in diploblasts such as the cnidarian Podocoryne carnea raises questions on the evolution of mesoderm, the third cell layer characteristic for triploblasts. Podocoryne Twist is expressed in the early embryo until the myoepithelial cells of the larva differentiate and then again during medusa development. There, the gene is detected first when the myoepithelial cells of the polyp dedifferentiate to form the medusa bud and later Twist is found transiently in the entocodon, a mesoderm-like cell layer which differentiates into the smooth muscle and striated muscle of the bell. On the other hand, in later bud stages and the medusa, expression is seen where non-muscle tissues differentiate. Experimental analysis of in vitro transdifferentiation and regeneration demonstrates that Twist activity is not needed when isolated striated muscle regenerate medusa organs. Developmental roles of Twist are discussed with respect to early animal evolution from a common ancestor of cnidarians and bilaterians.