[Clinical characteristics of patients with malignant neoplasms of the pancreas in case control studies in the Opole district]. / Kliniczna charakterystyka chorych na nowotwory zlosliwe trzustki w porównawczym badaniu przypadków w województwie opolskim.

Clinical data on 110 well-diagnosed cases of the pancreatic cancer collected in the study region between 1985 and 1987 by means of population case-control study are described. Out of 43.6% of the histologically diagnosed cases, 61.7% hand biopsy of the primary organ and 31.0% hand biopsy beyond the primary organ. There were 47.8% adenocarcinoma. Surgical findings (90% of the cases) included mainly isolated tumor of the head of pancreas (55.5%) or tumour of the head and other site of the organ (32.7%). 87.3% of the cancers was unifocal. Average diameter of tumour was 8 cm. Many metastases in gastrointestinal tract were found.

[Statistical correlations of the duration of survival and prognostic factors in the group of patients with Hodgkin's disease]. / Zaleznosci statystyczne dlugosci przezycia od czynników rokowniczych w grupie chorych na ziarnice zlosliwa.

Statistical relationships of the duration of survival and selected prognostic factors, in the group of 192 patients with Hodgkin's disease irradiated in the years 1965-1975 in the Institute of Oncology in Warsaw are discussed. The analysis of the multiple regressions has been performed and correlation coefficients of Pearson calculated. It has been found that following factors most effectively affect the prognosis: age, degree of remission obtained following first treatment and sex. The factor most strongly connected with the duration of the remission of the disease appears to be the degree of obtained remission.

Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for stomach cancer in Poland.

Urine samples were collected from 96 inhabitants of a high-risk rural area and a low-risk urban area for stomach cancer in Poland, according to the following protocol: (1) when they were undosed; (2) after ingestion of proline 3 times a day; and (3) after ingestion of proline together with vitamin C 3 times a day. The samples were analyzed for N-nitrosamino acids and nitrates, as indices of exposure to preformed and endogenously formed N-nitrosamines. The median values of N-nitrosoproline (NPRO) and N-nitrosothiazolidine 4-carboxylic acid (NTCA) excreted in the urine of undosed subjects were not different between the two areas; but N-nitrososarcosine and 3-(N-nitroso-N-methylamino)propionic acid levels were 3- to 4-fold higher in subjects of the high-risk area. After intake of proline, the NPRO level increased (p less than 0.02) only in subjects in the high-risk area; intake of vitamin C tended to inhibit this increase in NPRO and lowered the levels of other nitrosamino acids. The urinary level of nitrates was 1.4-fold, but significantly higher among subjects in the high-risk area than among those in the low-risk area; nitrate levels were not correlated with the amounts of cured meat or types of vegetables consumed. Urinary nitrate levels and excretion of NPRO, NTCA and the sum of all nitrosamino acids analyzed showed positive, though modest, correlations. These results indicate a higher potential for endogenous nitrosamine formation, possibly by intragastric nitrosation among subjects in the high-risk rural area.

[Comparison of the effectiveness of different methods of irradiation using metronidazole as a radiation-sensitizing agent in patients with laryngeal cancer. Controlled clinical studies]. / Porównanie skutecznosci róznych metod napromieniania z uzyciem metronidazolu jako radiouczulacza u chorych na raka krtani. Kontrolowane doswiadczenie kliniczne.

Randomized controlled clinical trial has been carried out in the Oncology Center in Warsaw and Medical Academy in Lódz to assess the effectiveness of application of Metronidazole as radiosensitizer of hypoxic cells in patients with squamous cell laryngeal cancer treated by Cobalt60 irradiation in the years 1982-1986. Clinical estimation has been obtained by comparison of the effectiveness of four selected methods of dose fractionation (conventional, dynamic, dynamic with Metronidazole, irradiation twice a day) in which NSD and TDF have been comparable (1950, 116). Metronidazole has been applied intraorally six times for a total treatment with 6 g doses. The tolerance of the drug has not been very good: 72% of patients has nausea and/or vomiting. No other side effects have been observed. Major mucosal reactions appeared in patients in which the dose have been fractionated by non conventional method (large fractions, twice daily irradiation). No statistically significant differences in the immediate effect of the radiotherapy and 3 year survival among the groups of patients treated by investigated methods have been found.