[Change in the content of free amino acids in brain tissue and blood plasma of rabbits under the effect of hydrocortisone]. / Zmina vmistu vil'nykh aminokyslot u tkanyni mozku ta plazmi krovi kroliv pid vplyvom hidrokortyzonu

The influence of a single and long term intramuscular hydrocortisone injections on the content of free amino acids was studied in the rabbit brain tissue and blood plasma. It is shown that exogenous hydrocortisone changes the content of certain amino acids in the brain. The changes in the free amino acids spectrum in blood plasma are more significant than in the brain under the hydrocortisone effect. The direction of the changes in blood plasma at the single and long term hormone administration is the same, their degree of expression depends on the time of administration.

[Peptide-hydrolase activity in different areas of brain with introduction of hydrocortisone and ACTH]. / Peptyd-hidrolazna aktyvnist' u piznykh viddilakh holovnoho mozku za vvedennia hidrokortyzonu i AKTH

A single introduction of hydrocortisone is established to evoke an increase in the total activity of acid peptide-hydrolase in most areas of the brain. A single administration of ACTH single and long term administration of hydrocortisone was found to increase the specific activity of acid peptide-hydrolase of the soluble fraction. The specific activity of neutral peptide-hydrolase of the soluble fraction increases with a single administration of ACTH and long term administration of hydrocortisone. A single and long term administration of hydrocortisone and ACTH cause an increase in the percentage of the soluble form of peptide-hydrolases of the total activity.