Subject(s)
Cyproterone/pharmacology , Hypothalamus/metabolism , Testis/physiology , Acid Phosphatase/metabolism , Alkaline Phosphatase/metabolism , Animals , Castration , Esterases/metabolism , Histocytochemistry , Hypothalamus/drug effects , Hypothalamus/ultrastructure , Male , Median Eminence/drug effects , Median Eminence/metabolism , Median Eminence/ultrastructure , RNA/metabolism , RatsSubject(s)
Epilepsy/metabolism , Hypothalamus/metabolism , Water/pharmacology , Acetylcholinesterase/metabolism , Acid Phosphatase/metabolism , Adenosine Triphosphatases/metabolism , Alkaline Phosphatase/metabolism , Animals , Cholinesterases/metabolism , Epilepsy/chemically induced , Esterases/metabolism , Histocytochemistry , Hypothalamus/enzymology , Hypothalamus/ultrastructure , Rats , Thiamine , Transferases/metabolismABSTRACT
PIP: Histochemical studies of the rat epididymis after treatment with alp ha-chlorohydrin (U-5897) are presented. 14 sexually mature male rats received either daily subcutaneous injections of 50 mg U-5907/kg body weight or distilled water for 20 days. The animals were sacrificed the day following the last injection. U-5897 induced temporary sterility as demonstrated by blocked transport of spermatozoa, and spermatogenic cells eliminated from the spermatogenic epithelium which became blocked in the caudal part of the epididymis. This resulted in the distension of the segment of the distal part of the epididymal duct and to the thinning of the epithelium which lined the altered segment. Alkaline and acid phosphatases, nonspecific esterases, succinate and glucose-6-phosphate dehydrogenases and reduced nicotinamide-adenine dinucleotide tetrazolium reductase in the unchanged part of the epididymal duct were comparable to control rats whereas the altered part of the epididymis showed these activities to much weaker degrees or to be absent altogether.^ieng
Subject(s)
Epididymis/enzymology , Propylene Glycols/pharmacology , Acid Phosphatase/metabolism , Alkaline Phosphatase/metabolism , Animals , Epididymis/drug effects , Epididymis/ultrastructure , Esterases/metabolism , Glucosephosphate Dehydrogenase/metabolism , Infertility, Male/chemically induced , Male , NADH, NADPH Oxidoreductases/metabolism , Rats , Spermatozoa/drug effects , Spermatozoa/enzymology , Spermatozoa/ultrastructure , Succinate Dehydrogenase/metabolismABSTRACT
PIP: Effects of chlormadinone acetate on the ovary were studied in 20 female Wistar rats. Chlormadinone was started on the 1st day of diestrus and given for 20 days; animals were killed 24 hours after the last administration. Examination of ovary sections revealed hyperplastic interstitial gland, a decreased number of corpora lutea and an increased number of atretic follicules. Histochemical studies indicated increased interstitial gland activity and full activity of atretic follicules.^ieng
