[Interaction between mutagenic activity and chemical structure in a series of biphenyl derivatives]. / Vzaimosviaz' mezhdu mutagennoi aktivnost'iu i khimicheskoi strukturoi v riadu proizvodnykh bifenila.

A comparative study of the mutagenic activity of 21 derivatives of biphenyl was performed in the strain TA1538 of Salmonella typhimurium. The position effect of carboxyl, amide, aldehyde, and ether groups was examined. The para position of substituents, among which at least one is a nitro group, causes mutagenic activity in most of the molecules studied. Derivatives of biphenyl that have no substituents in the para position were inactive. In addition, 4-nitrobiphenyl (4-NBP), 4-nitro-2'-carboxy biphenyl (4-N-2'-C-BP), 4,4'-dinitro-2'-carboxy biphenyl (4-4'-DN-2'-C-BP), and 4,4'-dinitro-2,2'-carboxy biphenyl (4-4'-DN-2,2'-DC-BP) induced no frameshift mutations in TA1538. The most active was 2,4,4'-TN-6-C-6'-Ad-BP, giving up to 800 revertants per nmol; 2,4,6,2'-TN-4'-6'-DC-BP and 2,4,2',4'-TN-2'-C-BP, which induced 250 and 350 revertants per nmol, respectively, were highly active frameshift mutagens.

[The effect of various structural features in molecules of derivatives of pyrene and its heterocyclic analogs on its mutagenic activity]. / Vliianie nekotorykh strukturnykh osobennostei v molekulakh proizvodnykh pirena i ego geterotsiklicheskikh analogov na ikh mutagennuiu aktivnost'.

The mutagenic potency of five acetyl and acetylamine derivatives of nitropyrene and 15 heterocyclic analogues of pyrene was studied in the strain Salmonella typhimurium TA1538. A significant impact of the electron-withdrawing acetyl group in the para-position on the mutagenic activity of derivatives of nitropyrene was shown. The para position of nitro and amino groups as well as of the amino and carboxyl group was also responsible for the mutagenic activity. A proposal for the existence of several cellular mechanisms of activation of molecules of heterocyclic analogues of pyrene is presented.

[Effect of structural features of nitro-derivatives of fluorenone and biphenyl on frameshift mutagenesis in tester strains of Salmonella typhimurium]. / Vliianie strukturnykh osobennostei nitroproizvodnykh fluorenona i bifenila na freimshift-mutagenez v testernykh shtammakh Salmonella typhimurium.

Comparative mutagenic activity of 7 derivatives of biphenyl and fluorenone, 4,4'-dinitrobiphenyl-2,2'-dicarboxylic acid; 4,4',6,6'-tetranitrobiphenyl-2,2'-dicarboxylamide; 2-nitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylamide; 2-nitrofluorenone-5,7-dicarboxylic acid; 2,4-dinitrofluorenone-5,7-dicarboxylic acid was studied. The highest activity was demonstrated for 2,7-DNF-5-KA and 2,7-DNF-5,7-DK which induced frameshift mutations in the tester strains Salmonella typhimurium TA1537, TA97, TA1538, TA98. High mutagenicity of these compounds is correlated with the position of nitro-groups and the effects of carboxylic and carboxyamide groups.

[A comparative analysis of mutagenic and SOS-induced activity in three classes of chemical compounds]. / Sravnitel'nyi analiz mutagennoi i SOS-indutsiruiushchei aktivnosti u khimicheskikh soedinenii trekh klassov.

Mutagenic and SOS-inducing potential of 23 derivatives of fluorenone, phenanthrenequinone and biphenyl have been studied in tester strains of Salmonella typhimurium and in Escherichia coli strain PQ 37. 14 of these compounds revert the mutation hisD3052 (much less than -1 much greater than type), but none of them induce mutations in the strain TA 1535. Maximal mutagenic activity has been shown in strain TA 1538 for amide of 2,7-dinitrofluorenone-4-carbonic acid (580 revertants per nmol), 2,7-dinitrophenanthrenequinone (308 revertants per nmol), 2,4,7-trinitrophenanthrenequinone (306 revertants per nmol) and 2',4,4'-trinitrobiphenyl-2-carbonic acid (251 revertants per nmol). In plasmid-containing strain TA 98 the mutagenic potential of the compounds tested is lower than in the TA 1538 strain. It has been suggested that mutagenic activity of these compounds can be attributed to their acceptor properties, namely, the ability to form charge transfer complexes with DNA. SOS-inducing activity has been shown for 5 compounds, also positive in mutation induction. Mutagenic and SOS-inducing activities positively correlate in fluorenone derivatives. Among phenanthrenequinone derivatives, compounds with high mutagenic activity only can induce SOS response. None of the biphenyls tested induce SOS functions. The compounds giving the positive result in the SOS-chromotest have rigid co-planar structure.

[Mutagenic effect of a tetrahydrodiazopyrene derivative on bacteria]. / O mutagennom deistvii proizvodnogo tetragidrodiazopirena na bakterii.

Mutagenic action of 3,7-diamino-4,9-dioxy-5,10-dioxo-4,5,9,10-tetrahydro-4,9-diazapiren (DDDTDP) was shown using indicator strains Salmonella typhimurium TA 1534, TA 1536, TA 1537, TA 1538. The drug-induced mutations in strains TA 1534 and TA 1538, and it can be used as a positive control in testing mutagens capable of inducing frameshift mutations. No significant differences was observed between DDDTDP effects on strains TA 1534 and TA 1538 which did or did not bear rfa mutation causing defects of cell wall lypopolysacharide complex. Within the range of concentrations tested DDDTDP had mutagenic effect without causing essential killing of bacteria. The mutagenic effect was decreased in the in vitro system of metabolic activation (Ames' plate test in Salmonella microsomes).