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1.
ACS Pharmacol Transl Sci ; 5(11): 1007-1016, 2022 Nov 11.
Article in English | MEDLINE | ID: mdl-36407951

ABSTRACT

Due to the lack of treatment options for the genetic disease primary hyperoxaluria (PH), including three subtypes PH1, PH2, and PH3, caused by accumulation of oxalate forming kidney stones, there is an urgent need for the development of a drug therapy aside from siRNA drug lumasiran for patients with PH1. After the recent success of drug therapies based on small interfering RNA (siRNA), nedosiran is currently being developed for the treatment of three types of PH as a siRNA-based modality. Through specific inhibition of lactate dehydrogenase enzyme, the key enzyme in biosynthesis of oxalate in liver, phase 1, 2, and 3 clinical trials of nedosiran have achieved the desired primary end point of reduction of urinary oxalate levels in patients with PH1. More PH2 and PH3 patients need to be tested for efficacy. It has also produced a favorable secondary end point on safety and toxicity in PH patients. In addition to common injection site reactions that resolved spontaneously, no severe nedosiran treatment-associated adverse events were reported. Based on the positive results in the clinical studies, nedosiran is a candidate siRNA drug to treat PH patients.

3.
Drug Metab Dispos ; 50(6): 888-897, 2022 06.
Article in English | MEDLINE | ID: mdl-35221287

ABSTRACT

Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug's pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs). The chemical structures, dosage forms, and sites and routes of administration are the principal determinants of ADME profiles and consequent impacts on their efficacy and ADRs. Newly developed large molecule biologic antisense oligonucleotide (ASO) drugs have completely unique ADME that is not fully defined. ASO-based drugs are single-stranded synthetic antisense nucleic acids with diverse modes of drug actions from induction of mRNA degradation, exon skipping and restoration, and interactions with proteins. ASO drugs have a great potential to treat certain human diseases that have remained untreatable with small molecule-based drugs. The ADME of ASO drugs contributes to their unique set of ADRs and toxicity. In this review, to better understand their ADME, the 10 US Food and Drug Administration (FDA)-approved ASO drugs were selected: fomivirsen, pegaptanib, mipomersen, nusinersen, inotersen, defibrotide, eteplirsen, golodirsen, viltolarsen, and casimersen. A meta-analysis was conducted on their formulation, dosage, sites of administration, local and systematic distribution, metabolism, degradation, and excretion. Membrane permeabilization through endocytosis and nucleolytic degradation by endonucleases and exonucleases are major ADME features of the ASO drugs that differ from small-molecule drugs. The information summarized here provides comprehensive ADME characteristics of FDA-approved ASO drugs, leading to a better understanding of their therapeutic efficacy and their potential ADRs and toxicity. Numerous knowledge gaps, particularly on cellular uptake and subcellular trafficking and distribution, are identified, and future perspectives and directions are discussed. SIGNIFICANCE STATEMENT: Through a systematic analysis of the existing information of absorption, distribution, metabolism, and excretion (ADME) parameters for 10 US Food and Drug Administration (FDA)-approved antisense oligonucleotide (ASO) drugs, this review provides an overall view of the unique ADME characteristics of ASO drugs, which are distinct from small chemical drug ADME. This knowledge is useful for discovery and development of new ASO drugs as well as clinical use of current FDA-approved ASO drugs.


Subject(s)
Biological Products , Drug-Related Side Effects and Adverse Reactions , Drug-Related Side Effects and Adverse Reactions/genetics , Exons , Humans , Oligonucleotides , Oligonucleotides, Antisense/genetics , Oligonucleotides, Antisense/therapeutic use , United States , United States Food and Drug Administration
4.
Trends Pharmacol Sci ; 43(3): 165-167, 2022 03.
Article in English | MEDLINE | ID: mdl-34887127

ABSTRACT

There is large interindividual variability in the efficacy of pre-exposure prophylaxis (PrEP) with tenofovir (TFV) in preventing HIV infection. Naturally occurring mutations in the creatine kinase M-type (CKM) gene examined by Mosher et al. could provide answers to why some individuals who have active serum creatine kinase in clinical assessments may not respond to TFV PrEP.


Subject(s)
Anti-HIV Agents , HIV Infections , Anti-HIV Agents/pharmacology , Anti-HIV Agents/therapeutic use , Creatine Kinase/therapeutic use , HIV Infections/drug therapy , HIV Infections/prevention & control , Humans , Muscles , Mutation , Tenofovir/therapeutic use
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