ABSTRACT
A new angucyclinone antibiotic, frigocyclinone, was isolated from Streptomyces griseus strain NTK 97, consisting of a tetrangomycin moiety attached through a C-glycosidic linkage with the aminodeoxysugar ossamine. Frigocyclinone showed antibacterial activities against Gram-positive bacteria.
Subject(s)
Anthraquinones/pharmacology , Anti-Bacterial Agents/pharmacology , Streptomyces griseus/metabolism , Antarctic Regions , Anthraquinones/isolation & purification , Anthraquinones/metabolism , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/isolation & purification , Chemical Phenomena , Chemistry, Physical , Chromatography, High Pressure Liquid , Fermentation , Gram-Positive Bacteria/drug effects , Microbial Sensitivity Tests , Models, Molecular , Spectrophotometry, UltravioletABSTRACT
A set of 600 actinomycetes strains which were isolated from marine sediments from various sites in the Pacific and Atlantic Oceans were screened for the production of bioactive secondary metabolites. Marine streptomycete strains were found to be producers of well known chemically diverse antibiotics isolated from terrestrial streptomycetes, as in the case of marine Micromonospora strains. New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032.
Subject(s)
Actinomycetales/isolation & purification , Actinomycetales/metabolism , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/isolation & purification , Geologic Sediments/microbiology , Actinomycetales/classification , Actinomycetales/growth & development , Atlantic Ocean , Culture Media/chemistry , Micromonosporaceae/classification , Micromonosporaceae/growth & development , Micromonosporaceae/isolation & purification , Micromonosporaceae/metabolism , Molecular Structure , Pacific Ocean , SeawaterABSTRACT
Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes resulted in very potent antithrombotic activity in vitro.
