ABSTRACT
Disturbances of erythrocyte and placental membrane functiond have been studied in placenta of pregnant women with obesity and diabetes mellitus type 2. The results of this study demonstrate significant metabolic impairments in women with insulin resistance. Changes in lipid spectrum of erythrocyte membranes and decreased activity of antioxidant enzymes obviously contribute to the development of fetoplacental insufficiency. This changes point to necessity of the antioxidant therapy in pregnant women with obesity and diabetes mellitus type 2.
Subject(s)
Erythrocyte Membrane/metabolism , Insulin Resistance , Membrane Lipids/metabolism , Obesity/metabolism , Placenta/metabolism , Pregnancy in Diabetics/metabolism , Adult , Antioxidants/metabolism , Diabetes Mellitus, Type 2/metabolism , Enzymes/metabolism , Erythrocyte Membrane/chemistry , Female , Glucosephosphate Dehydrogenase/metabolism , Humans , Lipid Peroxidation , Phospholipids/chemistry , Phospholipids/metabolism , Pregnancy , Pregnancy Complications/metabolism , Pregnancy Trimester, Third , Thyroxine/metabolism , Triiodothyronine/metabolismSubject(s)
Erythrocyte Membrane/metabolism , Pregnancy/blood , Adult , Blood Viscosity , Female , Humans , Lipid Peroxidation , Malondialdehyde/blood , Membrane Lipids/bloodABSTRACT
Activated lipid peroxidation (LPO) was found to occur with decreased antioxidative activity (AOA) in gestosis, by deteriorating the structural and functional properties of cell membranes. This enhanced the permeability of the phospholipid bilayer and altered the function of membranous proteins and the synthesis of biologically active agents, by involving the systems responsible for microcirculatory homeostasis. Enhanced membrane hydrophilicity and increased LPO and AOA are typical of the second and third trimesters of normal pregnancy. Pregnant with gestosis generally show higher microviscosity and hydrophilicity of membranes and enhanced blood LPO.
