1.
J Antibiot (Tokyo)
; 77(4): 206-213, 2024 04.
Article
in English
| MEDLINE
| ID: mdl-38302743
ABSTRACT
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.
Subject(s)
Antimalarials , Lactams , Epoxy Compounds
2.
J Antibiot (Tokyo)
; 75(4): 199-206, 2022 04.
Article
in English
| MEDLINE
| ID: mdl-35241792
ABSTRACT
Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.