Deep learning-based low-dose CT simulator for non-linear reconstruction methods.

BACKGROUND: Computer algorithms that simulate lower-doses computed tomography (CT) images from clinical-dose images are widely available. However, most operate in the projection domain and assume access to the reconstruction method. Access to commercial reconstruction methods may often not be available in medical research, making image-domain noise simulation methods useful. However, the introduction of non-linear reconstruction methods, such as iterative and deep learning-based reconstruction, makes noise insertion in the image domain intractable, as it is not possible to determine the noise textures analytically. PURPOSE: To develop a deep learning-based image-domain method to generate low-dose CT images from clinical-dose CT (CDCT) images for non-linear reconstruction methods. METHODS: We propose a fully image domain-based method, utilizing a series of three convolutional neural networks (CNNs), which, respectively, denoise CDCT images, predict the standard deviation map of the low-dose image, and generate the noise power spectra (NPS) of local patches throughout the low-dose image. All three models have U-net-based architectures and are partly or fully three-dimensional. As a use case for this study and with no loss of generality, we use paired low-dose and clinical-dose brain CT scans. A dataset of 326 $\hskip.001pt 326$ paired scans was retrospectively obtained. All images were acquired with a wide-area detector clinical system and reconstructed using its standard clinical iterative algorithm. Each pair was registered using rigid registration to correct for motion between acquisitions. The data was randomly partitioned into training ( 251 $\hskip.001pt 251$ samples), validation ( 25 $\hskip.001pt 25$ samples), and test ( 50 $\hskip.001pt 50$ samples) sets. The performance of each of these three CNNs was validated separately. For the denoising CNN, the local standard deviation decrease, and bias were determined. For the standard deviation map CNN, the real and estimated standard deviations were compared locally. Finally, for the NPS CNN, the NPS of the synthetic and real low-dose noise were compared inside and outside the skull. Two proof-of-concept denoising studies were performed to determine if the performance of a CNN- or a gradient-based denoising filter on the synthetic low-dose data versus real data differed. RESULTS: The denoising network had a median decrease in noise in the cerebrospinal fluid by a factor of 1.71 $1.71$ and introduced a median bias of + 0.7 $ + 0.7$ HU. The network for standard deviation map estimation had a median error of + 0.1 $ + 0.1$ HU. The noise power spectrum estimation network was able to capture the anisotropic and shift-variant nature of the noise structure by showing good agreement between the synthetic and real low-dose noise and their corresponding power spectra. The two proof of concept denoising studies showed only minimal difference in standard deviation improvement ratio between the synthetic and real low-dose CT images with the median difference between the two being 0.0 and +0.05 for the CNN- and gradient-based filter, respectively. CONCLUSION: The proposed method demonstrated good performance in generating synthetic low-dose brain CT scans without access to the projection data or to the reconstruction method. This method can generate multiple low-dose image realizations from one clinical-dose image, so it is useful for validation, optimization, and repeatability studies of image-processing algorithms.

Deep learning for x-ray scatter correction in dedicated breast CT.

BACKGROUND: Accurate correction of x-ray scatter in dedicated breast computed tomography (bCT) imaging may result in improved visual interpretation and is crucial to achieve quantitative accuracy during image reconstruction and analysis. PURPOSE: To develop a deep learning (DL) model to correct for x-ray scatter in bCT projection images. METHODS: A total of 115 patient scans acquired with a bCT clinical system were segmented into the major breast tissue types (skin, adipose, and fibroglandular tissue). The resulting breast phantoms were divided into training (n = 110) and internal validation cohort (n = 5). Training phantoms were augmented by a factor of four by random translation of the breast in the image field of view. Using a previously validated Monte Carlo (MC) simulation algorithm, 12 primary and scatter bCT projection images with a 30-degree step were generated from each phantom. For each projection, the thickness map and breast location in the field of view were also calculated. A U-Net based DL model was developed to estimate the scatter signal based on the total input simulated image and trained single-projection-wise, with the thickness map and breast location provided as additional inputs. The model was internally validated using MC-simulated projections and tested using an external data set of 10 phantoms derived from images acquired with a different bCT system. For this purpose, the mean relative difference (MRD) and mean absolute error (MAE) were calculated. To test for accuracy in reconstructed images, a full bCT acquisition was mimicked with MC-simulations and then assessed by calculating the MAE and the structural similarity (SSIM). Subsequently, scatter was estimated and subtracted from the bCT scans of three patients to obtain the scatter-corrected image. The scatter-corrected projections were reconstructed and compared with the uncorrected reconstructions by evaluating the correction of the cupping artifact, increase in image contrast, and contrast-to-noise ratio (CNR). RESULTS: The mean MRD and MAE across all cases (min, max) for the internal validation set were 0.04% (-1.1%, 1.3%) and 2.94% (2.7%, 3.2%), while for the external test set they were -0.64% (-1.6%, 0.2%) and 2.84% (2.3%, 3.5%), respectively. For MC-simulated reconstruction slices, the computed SSIM was 0.99 and the MAE was 0.11% (range: 0%, 0.35%) with a single outlier slice of 2.06%. For the three patient bCT reconstructed images, the correction increased the contrast by a mean of 25% (range: 20%, 30%), and reduced the cupping artifact. The mean CNR increased by 0.32 after scatter correction, which was not found to be significant (95% confidence interval: [-0.01, 0.65], p = 0.059). The time required to correct the scatter in a single bCT projection was 0.2 s on an NVIDIA GeForce GTX 1080 GPU. CONCLUSION: The developed DL model could accurately estimate scatter in bCT projection images and could enhance contrast and correct for cupping artifact in reconstructed patient images without significantly affecting the CNR. The time required for correction would allow its use in daily clinical practice, and the reported accuracy will potentially allow quantitative reconstructions.

Analysis of ancient ceramics using terahertz imaging and photogrammetry.

Imaging using terahertz time-domain spectroscopy is a valuable diagnostic tool for material inspection. However, in the case of samples with inhomogeneous shape and composition, the reliable extraction of spatially varying dielectric properties can be very challenging. Here, we demonstrate a new approach which combines THz-TDS with photogrammetric reconstruction. We show that this technique can be used to estimate the local refractive index of samples with a complex geometry. We employ this method to study samples of ancient pottery, and demonstrate that THz techniques can provide a valuable new tool for this branch of archaeological science.

Enhancing the performance of THz quasi time-domain spectroscopy systems by low duty cycle laser operation.

We investigate the performance of terahertz (THz) quasi time-domain systems (QTDS) driven by electrically pulsed multi-mode laser diodes operating at 659 nm. We show that at the same average output power, a reduced duty cycle considerably increases the obtained bandwidth. In the presented experiment, the high frequency performance is improved by 50 dB/THz. We identify the broadening of the optical spectrum caused by pulsing the laser source to be responsible for the increased THz bandwidth.