Subject(s)
Antioxidants/metabolism , Neoplasms, Experimental/metabolism , Animals , Catalase/metabolism , Cricetinae , Glutathione/metabolism , Glutathione Peroxidase/metabolism , Mesocricetus , Neoplasms, Experimental/enzymology , Neoplasms, Experimental/pathology , Superoxide Dismutase/metabolism , Tumor Cells, Cultured , Vitamin E/metabolismABSTRACT
Positive changes of respiratory function parameters and oxidation-reduction processes observed in 55 patients with lung cancer and low functional respiratory reserve indicate the advisability of introducing antioxidants and antiaggregants (cytochrome C, aevitum, Trental, rheopolyglucin) into complex intensive preoperative correcting therapy for the expansion of indications for surgery and attenuation of the operative risk.
Subject(s)
Antioxidants/therapeutic use , Lung Neoplasms/complications , Respiratory Insufficiency/therapy , Critical Care , Humans , Respiratory Insufficiency/etiologyABSTRACT
The disturbed lipid peroxidation and oxidation-reduction processes revealed in patients with lung cancer should be regarded as decompensation of intracellular metabolic mechanisms. The degree of the above disturbances demands correction by using antioxidants both in the pre- and early postoperative period, which is directly confirmed by the results of surgical treatment of patients with lung cancer. To predict the course of the postoperative period, one, along with clinical data, can use such indexes as malonic aldehyde content and superoxide dismutase activity.