ABSTRACT
BACKGROUND: Although many egg- and milk-allergic children tolerate baked egg (BE) and baked milk (BM), reactions elicited by these oral food challenges (OFCs) can be severe. Previous studies comparing BE and BM reactions to other OFC reactions are limited. OBJECTIVE: To compare the clinical features of reactions to BE and BM with other OFCs to promote challenge safety. METHODS: A retrospective review of OFCs eliciting objective reactions to BE, BM, lightly cooked egg (CE), fresh cow's milk (CM), peanut (PN), and tree nuts (TN) which were performed at a tertiary referral center from June 1, 2017, to June 1, 2019. RESULTS: We identified 174 OFCs conducted in 158 subjects, age 6 to 187 months (34 BE, 19 BM, 14 CE, 25 CM, 52 PN, and 30 TN). TN reactors were older than BE (P = .049) and PN (P < .01) reactors and had a higher frequency of persistent asthma than PN-reactive subjects (P = .02). Mucocutaneous symptoms occurred less frequently during BE (56%) and BM (42%) OFCs compared with other OFCs (P < .05). Lower respiratory tract reactions were increased during BM (37%) versus BE (12%), CM (8%), and PN (12%) OFCs (P < .05). Epinephrine was administered to more BE (44%) and TN (50%) than PN (17%) OFCs (P < .01). New reaction manifestations developed 60 minutes or later after OFC termination during 29% BE and 21% BM versus 0% PN OFCs (P < .05). One-third of anaphylactic reactions to BE began more than 60 minutes after OFC termination. CONCLUSIONS: BE and BM challenge reactions differed phenotypically from other OFC reactions, including significantly increased frequencies of new symptoms beginning 60 minutes or later after challenge termination. Consider amended dose-escalation and prolonged observation after BE and BM OFCs.
Subject(s)
Anaphylaxis , Milk Hypersensitivity , Allergens , Anaphylaxis/epidemiology , Animals , Cattle , Child , Female , Humans , Immunoglobulin E , Milk , Milk Hypersensitivity/diagnosis , Milk Hypersensitivity/epidemiology , Retrospective StudiesABSTRACT
A landmark study showed that early peanut introduction in high-risk infants, defined as infants with moderate to severe atopic dermatitis or egg allergy, reduced the risk of developing peanut allergy. Since this trial, many international societies have updated feeding guidelines to promote early introduction of peanut, usually around 6 months of age. Implementing these guidelines on a national and international level has been challenging. Furthermore, there is confusion if allergy testing is needed before peanut introduction in high-risk infants. Despite these challenges, the data are promising, that implantation of early introduction guidelines can reduce the burden of peanut allergy.
Subject(s)
Allergens/immunology , Arachis/adverse effects , Peanut Hypersensitivity/immunology , Peanut Hypersensitivity/prevention & control , Allergens/administration & dosage , Breast Feeding , Clinical Trials as Topic , Humans , Infant , Infant Formula , Peanut Hypersensitivity/epidemiology , Practice Guidelines as Topic , SiblingsSubject(s)
Antigens, Dermatophagoides/immunology , Desensitization, Immunologic/methods , Hypersensitivity/diagnosis , Immunoglobulin E/metabolism , Rhinitis/diagnosis , Animals , Child, Preschool , Chronic Disease , Dogs , Humans , Male , Pyroglyphidae/immunology , Reference Standards , Reproducibility of ResultsABSTRACT
Recently, the National Institute of Allergy and Infectious Diseases sought to establish consistency in definitions, diagnostic criteria, and management practices concerning food allergies (FAs). This review aimed to summarize and highlight the relevant findings of these guidelines for the emergency department provider, as pediatric patients often present to the emergency department with FAs or other disorders mimicking FAs.
Subject(s)
Anaphylaxis/diagnosis , Food Hypersensitivity/diagnosis , Anaphylaxis/drug therapy , Child , Diagnosis, Differential , Emergency Service, Hospital , Food Hypersensitivity/drug therapy , HumansABSTRACT
We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.
