ABSTRACT
Side-effects and incomplete response to standard therapy of patients with multiple sclerosis (MS) stimulate the development of an alternative therapy, that influences, in particular, metabolic functions of MS patients. Metabolic therapy (vitamins, antioxidants and others) have been used for a long time in neurologic practice for the treatment of MS on the basis of pathophysiological mechanisms, positive clinical experience, low rate of side-effects and practical availability. Recent objective scientific data explain the necessity of correction of the disturbed metabolic profile (metabolome) in MS, and the first evidence of the efficacy of several metabolic agents, particularly, biotin and vitamin D, was shown. Taking into account the mechanisms of action and clinical experience, the authors consider the prospects of using the combined medicine cytoflavin, that contains succinate, nicotinamide, riboflavin and inosine, in metabolic therapy of MS.
Subject(s)
Antioxidants , Multiple Sclerosis , Vitamin B Complex , Antioxidants/therapeutic use , Humans , Multiple Sclerosis/therapy , Vitamin B Complex/therapeutic useABSTRACT
In 1860 year in Medical-surgical academy in St. Petersburg was found the first department of nervous and mental diseases. With this department are aligned names of the greatest native neurologists and psychiatrists (Merzheevsky I.P., Bekhterev V.M., Blumenau L.V., Astvatsarov M.I., Dojnikov B.S., Triumfov A.V., Razdolsky I.Ya., Panov A.G. and etc.) who took the glory of Russian neurology. For 150 years the department was the base of neurological specialists for all medical institutes of the state. The department keeps the single educational and scientific institute, supplying systematic and high-qualified preparedness of military neurologists.
Subject(s)
Education, Medical, Graduate/history , Mental Disorders , Military Medicine/history , Nervous System Diseases , Schools, Medical/history , History, 19th Century , History, 20th Century , History, 21st Century , Humans , RussiaSubject(s)
Academies and Institutes/history , Anniversaries and Special Events , Education, Medical/history , General Surgery/history , Mental Disorders/history , Nervous System Diseases/history , General Surgery/education , History, 19th Century , History, 20th Century , History, 21st Century , Humans , Russia , Russia (Pre-1917)ABSTRACT
The article presents a biographic sketch, devoted to one of founders of histopathology of peripheral nervous system--Doynikov B.S. (1879-1948) - professor of Military-medical academy, author of fundamental monographies "General histology and histopathology of peripheral somatic nervous system" and "General histology and histopathology of peripheral vegetative nervous system".
Subject(s)
Histology/history , Military Medicine/history , Pathology, Clinical/history , Anniversaries and Special Events , History, 19th Century , History, 20th Century , HumansSubject(s)
Nervous System Diseases/history , Neurology/history , History, 19th Century , Humans , Russia (Pre-1917)ABSTRACT
The authors present an analysis of scientific conceptions of epilepsy by the outstanding scientist and physician Herman Boerhaavey. All aspects of the disease, including etiology, pathogenesis, clinical presentations, rehabilitation, treatment, were described in the manuscripts devoted to neurology from the archive of H. Boerhaave in the Military Medical Academy.
Subject(s)
Epilepsy/history , Psychiatry/history , History, 18th Century , Humans , NetherlandsSubject(s)
Chlamydia Infections/diagnosis , Chlamydia/isolation & purification , Nervous System Diseases/diagnosis , Nervous System Diseases/parasitology , Nervous System/parasitology , Adult , Animals , Anti-Bacterial Agents/therapeutic use , Chlamydia Infections/complications , Chlamydia Infections/therapy , Female , Humans , Male , Middle Aged , Nervous System Diseases/therapySubject(s)
Encephalitis, Tick-Borne/history , Neurology/history , Animals , History, 20th Century , Humans , RussiaABSTRACT
The examination of 180 patients with acute neuroinfection (105 males, 75 females at the age from 18 to 45 years) has detected C. trachomatis in 23.8%, C. Pneumoniae in 66.6%, C. psittaci in 9.5% patients. Acute and chlamydial lesions of the central nervous system were characterized by all forms of neuroinfection: serous and purulent meningitides, meningoencephalitides. Development of acute neuroinfection is accompanied by sluggish chlamydial infection of the viscera.
