[The influence of inhibitors of kinin and prostaglandin formation on the vascular and tubular effects of osmotic diuretics in the kidney]. / Vliianie ingibitorov obrazovaniia kininov i prostaglandinov na sosudistyi i kanal'tsevyi éffekty osmoticheskikh diuretikov v pochke.

Mannit was shown to increase the blood flow in the external, middle and internal zone of the renal cortex in anesthetized rats but exerts no effect on the blood supply to the external zone of the medullary layer. A preliminary administration of contrykal fails to influence the diuretic and natriuretic effects of the preparation and to change the character of the hemodynamic shift at the action of the diuretic in the middle zone of the cortical layer. Indomethacin completely eliminates the blood flow increase in the middle zone of the cortex but it does not prevent the diuretic and natriuretic reaction to mannit administration. It is concluded that realization of the vascular and tubular effects of the diuretic is not related to the increase of kinin biosynthesis in the kidneys. Prostaglandins formed in the kidneys under the influence of mannit are involved in the mechanism of dilatation of the vessels of the cortical layer but do not play the significant role in the formation of its tubular effect.

[Role of kidney prostaglandins, kinins and dopamine receptors in the natriuretic effect of ethacrynic acid]. / Rol' pochechnykh prostaglandinov, kininov i dofaminovykh retseptorov v natriiureticheskom éffekte étakrinovoi kisloty.

It was found in experiments on anesthetized rats that ethacrynic acid (3 mg/kg intravenously) exerted no effect on the blood flow in the internal zone of the cortical layer but significantly increased the blood supply to the median zone of this region of the kidneys. A pronounced natriuretic reaction produced by inhibition of this ion develops. An inhibitor of cyclooxygenase indomethacin (3 mg/kg orally, 5 days) completely eliminated an increase of the blood flow in the cortical median zone but failed to prevent an increase of diuresis and urinary excretion of sodium in response to the diuretic administration. An inhibitor of kallikrein contrykal (5000 U/kg subcutaneously) produced no effect on diuretic and natriuretic effects of the drug but prevented the hemodynamic shift in the renal cortex. A blocker of dopaminergic receptors haloperidol (3 mg/kg subcutaneously) caused no changes in the rat kidney response to ethacrynic acid. Prostaglandins and kinins formed in the kidneys under the influence of the diuretic are thought to be involved in the mechanism of dilatation of vessels of the cortical layer median zone but play no significant role in the formation of its natriuretic effect.

[Furosemide interaction with the prostaglandin and kallikrein-kinin systems of the kidneys]. / Vzaimodeistvie furosemida s prostaglandinovoi i kallikrein-kininovoi sistemami pochek.

Indomethacin (3 mg/kg, orally for 5 days) prevented the increase of blood flow in the internal zone of the renal cortical layer but failed to interfere with the increase of diuresis and sodium secretion produced by furosemide (2 mg/kg, subcutaneously) in anesthetized rats. Contrykal (6000 ED, subcutaneously) failed to alter the character of the hemodynamic changes in the renal cortex but enhanced the diuretic and natriuretic effects of furosemide. In unanesthetized rats indomethacin prevented creatinine urine excretion but didn't attenuate the diuretic and natriuretic effects of furosemide.