ABSTRACT
Urban railway vehicles are important means of transport in towns and cities due to their high capacity, power source, and low running resistance, which make them efficient for operation. Although these properties are considered advantages, there is still room for improvement in their operational efficiency. The main objective of this article is to investigate the impact of railway wheel design on the level of kinematic running resistance, which is expressed as the amount of mechanical energy losses during the interaction of wheels with rails. This research focuses on simulation computations of two variants of wheel design schemes: the traditional design scheme (TKS) and a perspective design scheme (PKS) characterized by a rotating flange independently of the wheel tread surface. Two undercarriage multibody models have been created, one with TKS and one with PKS, and simulation computations have been performed for running speeds of 10 km/h, 20 km/h, 30 km/h, and 40 km/h on track models in curves with radii of 20, 50, 100, 150, 200, and 250 m. The evaluated indicators affecting the level of mechanical energy losses were creep forces, slip velocities, and average power. The most important findings of this study are that the PKS design scheme resulted in lower values of all assessed parameters.
ABSTRACT
Background and Aim: Mastitis is recognized as the most common disease in cattle and causes economic losses in the dairy industry. A number of opportunistic bacterial taxa have been identified as causative agents for this disease. Conventionally, antibiotics are used to treat mastitis; however, most bacteria are resistant to the majority of antibiotics. This study aimed to use molecular methods to identify milk microbiome patterns characteristic of mastitis that can help in the early diagnosis of this disease and in the development of new treatment strategies. Materials and Methods: To evaluate the microbiome composition, we performed NGS sequencing of the 16S rRNA gene of the V3 region. Results: An increase in the abundance of the bacterial genera Hymenobacter and Lachnospiraceae NK4A136 group is associated with the development of subclinical and clinical mastitis in dairy cows. These bacteria can be added to the list of markers used to detect mastitis in cows. Furthermore, a decrease in the abundance of Ralstonia, Lachnospiraceae NK3A20 group, Acetitomaculum, Massilia, and Atopostipes in cows with mastitis may indicate their role in maintaining a healthy milk microbiome. Antibiotics reduced the levels of Streptococcus in milk compared to those in the healthy group and cows before antibiotic treatment. Antibiotic therapy also contributed to an increase in the abundance of beneficial bacteria of the genus Asticcacaulis. Conclusion: This study expands our understanding of the association between milk microbiota and mastitis.
ABSTRACT
The development of new herbal preparations for the treatment of urolithiasis is an urgent task of medical science. Ficus have attracted the attention of pharmacologists due to a wide range of biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied the effectiveness of Ficus tikoua Bur. in SD rats in which urolithiasis was induced by 6 weeks of oral administration of ethylene glycol 0.5% ad libitum instead of drinking water. Administration of the extract of Ficus tikoua Bur., as well as comparative drug Cystone® after modeling of urolithiasis lead to the restoration of diuresis and the concentration of inorganic phosphates starting from the 6th week of the experiment. The use of the Ficus tikoua Bur. extract for 6 weeks, both during the modeling of urolithiasis and during the recovery period, led to the restoration of the percentage of lymphocytes in the blood, content of sodium, chlorine and inorganic phosphates in the blood to the control level. Thus, the extract of Ficus tikoua Bur. seems to be a promising drug for effective treatment of the initial stages of the development of urolithiasis.
ABSTRACT
Ride comfort for passengers remains a pressing topic. The level of comfort in a vehicle can influences passengers' preferences for a particular means of transport. The article aims to evaluate the influence of changes in suspension parameters on the ride comfort for passengers. The theoretical background includes a description of the applied method for a creating the virtual model of an investigated vehicle as well as the method of evaluating the ride comfort. The ride comfort of the vehicle is assessed based on the standard method, which involves calculating the mean comfort method, i.e., ride comfort index NMV in chosen points on a body floor. The NMV ride comfort index (Mean Comfort Standard Method) requires the input of acceleration signals in three directions. The rest of the article offers the results of simulation computations. The stiffness-damping parameters of the primary and secondary suspension systems were changed at three levels and the vehicle was run on the real track section. The ride index NMV was calculated for all three modifications of the suspension system in the chosen fifteen points of the body floor. It was found that lower values in the stiffness of the secondary suspension system lead to lower levels of ride comfort in the investigated railway passenger car; however, lower values in the stiffness-damping parameters of the primary suspension system did not decrease the levels of ride comfort as significantly.
