ABSTRACT
Clinical observation with morphological verification of the above combination in a 48-year-old patient is presented. Large cysts, dystelectasia, fibrosis and smooth muscle proliferation were found in the lungs. The characteristic feature of smooth muscle cells was their differentiation in the direction of myofibroblasts and expression of antigen interacting with HMB-45 antibodies as well as protein products involved in catecholamine metabolism and estrogen receptors.
Subject(s)
Leiomyoma/pathology , Leiomyomatosis/pathology , Lung Neoplasms/pathology , Lymphangioleiomyomatosis/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Uterine Neoplasms/pathology , Angiolipoma/pathology , Diagnosis, Differential , Female , Humans , Kidney Neoplasms/pathology , Middle AgedSubject(s)
Air Pollutants, Occupational/toxicity , Blood Cells/drug effects , Dark Adaptation/drug effects , Drug Industry , Hypersensitivity, Delayed/chemically induced , Tretinoin/toxicity , Vitamin A/analogs & derivatives , Adult , Anemia/chemically induced , Blood Cell Count/drug effects , Diterpenes , Female , Humans , Leukocytosis/chemically induced , Middle Aged , Retinyl Esters , Tretinoin/chemical synthesis , Vitamin A/chemical synthesis , Vitamin A/toxicityABSTRACT
Human and animal blood smear staining with PAPh has revealed mononuclear leukocyte-erythrocyte aggregates. Administration of retinoic acid increased concentration and dimensions of these aggregates and was followed by preferential accumulation of PAPh-negative osmotically unstable erythrocytes. Similar changes were detected in the blood samples of women engaged in the production of retinoic acid. Aggregate concentration showed positive correlation with erythrocyte sedimentation rate and no correlation with prothrombin time.
Subject(s)
Erythrocyte Aggregation/drug effects , Leukocytes/drug effects , Tretinoin/pharmacology , Animals , Cell Aggregation/drug effects , Erythrocytes/metabolism , Female , Leukocytes/metabolism , Male , Mice , Osmolar Concentration , Rosette Formation , Staining and LabelingABSTRACT
The influence of retinyl acetate, retinoic acid and its esterified cis- and trans-derivatives, retinoids C15 and C20 on erythrocytes, liver macrophages and white pulp of the spleen was studied in the experiments on mice of different strains. It was found that administration of these compounds leads to the damage of the blood cells, increase in the number of liver macrophages and the share of white pulp in the spleen and stimulation of the local response to tuberculin. The interdependence of changes in the blood and adjuvant is suggested.
Subject(s)
Adjuvants, Immunologic/pharmacology , Erythrocytes/drug effects , Retinoids/pharmacology , Animals , Diterpenes , Female , Liver/drug effects , Macrophages/drug effects , Male , Mice , Mice, Inbred CBA , Retinyl Esters , Spleen/drug effects , Tretinoin/analogs & derivatives , Tretinoin/pharmacology , Vitamin A/analogs & derivatives , Vitamin A/pharmacologyABSTRACT
The ability of six retinoids to inhibit cancer growth was tested on mice with Lewis lung carcinoma, PRG and RSM-5 tumors. It was shown that all tumors possess individual sensitivities to retinoids. The most effective substances were: methyl retinoate (all-trans and 13-cis isomers) and a retinoid with a small side chain and an oxidated beta-iononic ring (substance 3). Each of those three retinoids was tested for an ability to prevent methylcholanthrene-induced carcinogenesis in the skin. All-trans methylretinoate had the most pronounced effect; however, it was the most toxic, too.
Subject(s)
Neoplasms, Experimental/drug therapy , Vitamin A/analogs & derivatives , Animals , Chemical Phenomena , Chemistry , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Mice , Neoplasms, Experimental/pathology , Skin Neoplasms/drug therapy , Vitamin A/therapeutic useABSTRACT
It has been shown that all-trans-methylretinoate, 13-cis-methyl retinoate and retinoid C15 administered intraperitoneally in the form of 0.05% solutions in excess doses reduce the red cell count, hemoglobin content, and osmotic resistance of red cells in C57Bl/6 mice. Administration of 13-cis-methylretinoate and retinoid C15 resulted in the increase of the number of cells uncapable to stain with paraldehyde fuchsin. Anemia induced by all-trans-methylretinoate in AKR mice was accompanied by erythropoiesis enhancement in the bone marrow.
