ABSTRACT
An appreciable increase in the number of aberrant lymphocytes was detected in the peripheral blood of patients with febrile form of tick-borne encephalitis (TBE). This increase peaked during week 2 of the infectious process and was paralleled by a decrease in the count of natural killer cells. By the end of the acute period of neuroinfection the number of cells with structural chromosome aberrations decreased, but still surpassed the control (donor blood). Genetically unstable cells were eliminated predominantly at the expense of lymphocytes with chromatid disorders, while the count of CD16-expressing lymphocytes increased. The intensity of reparative DNA synthesis was suppressed during the entire acute period of tick-borne encephalitis.
Subject(s)
Chromosome Aberrations , Encephalitis, Tick-Borne/blood , Encephalitis, Tick-Borne/genetics , Lymphocytes/ultrastructure , Adult , DNA/biosynthesis , DNA Repair , Encephalitis Viruses, Tick-Borne/pathogenicity , Female , Fever/virology , Humans , Lymphocytes/blood , Lymphocytes/immunology , Male , Middle Aged , Receptors, IgG/analysisABSTRACT
We studied metabolic and functional activity of peripheral blood phagocytes from patients with febrile tick-borne encephalitis. Phagocytic activity of neutrophils determining nonspecific resistance of the organism progressively increased, while metabolic activity decreased. Secretion of nitric oxide by peripheral blood mononuclear phagocytes was suppressed, while phagocytic functions of these cells remained unchanged.
Subject(s)
Encephalitis, Tick-Borne/blood , Monocytes/physiology , Neutrophils/physiology , Acute Disease , Adult , Female , Humans , Male , Middle Aged , Monocytes/metabolism , Neutrophils/metabolism , Nitric Oxide/blood , Nitric Oxide/metabolismABSTRACT
Study of the surface phenotype, structure of plasma membrane, and activity of DNA repair system in peripheral blood lymphocytes from patients with different clinical forms of tick-borne encephalitis associated with long persistence of the virus revealed a pronounced imbalance between lymphocyte subpopulations, increased microviscosity of the plasma membrane lipid phase, and decreased activity of the DNA repair system in lymphocytes.
