ABSTRACT
The efficacy of cortexine used to treat patients with unstabilized primary open-angle glaucoma (OAG) was studied after penetrating through trophic sclerectomy with cyclodialysis. Thirty-nine patients (58 eyes) with developed OAG were examined. All the patients underwent penetrating trophic sclerectomy with cyclodialysis, followed by a course of subconjunctival injections of cortexine 10 mg. The positive effect persisted for 1.5 years and a stabilizing glaucomic process was observed in 78% of the patients.
Subject(s)
Glaucoma, Open-Angle/therapy , Peptides/therapeutic use , Sclerostomy/methods , Aged , Conjunctiva , Disease Progression , Follow-Up Studies , Glaucoma, Open-Angle/physiopathology , Humans , Injections , Intercellular Signaling Peptides and Proteins , Intraocular Pressure , Middle Aged , Peptides/administration & dosage , Treatment OutcomeABSTRACT
Eighty-three patients (119 eyes) with partial optic nerve atrophy of different origin were treated by amplipulse phoresis and observed for 1 year. Based on the data of modern methods of examination of visual functions (changes in visual evoked potentials and achromatic static campimetry), the authors suggest that several mechanisms of visual function improvement underlie the therapeutic effect of amplipulse phoresis. These mechanisms are as follows: activation of the intact part of nerve fibers with restoration of myelin membranes, restoration of viability of nerve fibers in a state of parabiosis; a probable mechanism of visual acuity improvement is modification of the conduction of visual route on-channels, but this hypothesis needs further investigations.
Subject(s)
Ocular Physiological Phenomena , Optic Atrophy/therapy , Optic Nerve/physiology , Evoked Potentials, Visual/physiology , Humans , Optic Atrophy/physiopathology , Optic Atrophy/surgery , Physical Therapy Modalities , Time Factors , Vision, Ocular/physiology , Visual Acuity , Visual Field TestsABSTRACT
A new complex method for treating partial atrophies of the optic nerve unites surgical, physiotherapeutic, and drug effects. One electrode is attached directly to the anterior segment of the optic nerve by a collagen infusion system and the other is fixed at the back of the neck. The involved optic nerve is exposed to sinusoidal modulated currents in the rectified mode, permitting direct drug electrophoresis in parallel with electric stimulation of nerve fibers. The efficiency of the method is two times higher than of standard treatment.
