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Bull Exp Biol Med ; 134(1): 78-80, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12459876

ABSTRACT

The quantitative micronucleus test showed that the natural dipeptide carnosine increases the count of aberrant spermatogonia and round spermatids in the testes in SAMR1 mice resistant to accelerated aging by 64 and 85%, respectively, compared to the control. However, this agent did not modify the incidence of chromosome mutations in spermatogenic cells in SAMP1 mice predisposed to accelerated aging.


Subject(s)
Aging , Carnosine/pharmacology , Cellular Senescence , Testis/drug effects , Animals , Carnosine/metabolism , Male , Mice , Mice, Inbred Strains , Micronucleus Tests , Spermatids/drug effects , Spermatogonia/drug effects
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