ABSTRACT
A synthetic carbon sorbent (SKNP-2) was included in the treatment of 197 patients with relapsing urticaria. Courses lasted 7, 14, 20 days. The clinical effect was favourable and its efficacy increased with prolongation of the therapy course time using the enterosorbent. Immunological parameters did not change in the course of treatment.
Subject(s)
Enterosorption/methods , Urticaria/therapy , Adolescent , Adult , Aged , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Humans , Immunoglobulins/analysis , Middle Aged , Recurrence , Urticaria/immunologyABSTRACT
The principles of physical and chemical immobilization of 14C-albumin on synthetic carbon sorbents with different physiochemical characteristics and structures are studied with radioisotopic technique. The protein binding to the matrix is shown to occur more tightly in the presence of the activating agent (water soluble carbodiimide). It is marked that the geometric correlation of the protein molecular size and sorbents mezopores dimensions is critical for the effective immobilization. The synthetic spherogranulated CKH carbons are shown to be preferential for biospecific carbon sorbents creation.
