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1.
Bull Exp Biol Med ; 147(1): 132-46, 2009 Jan.
Article in English | MEDLINE | ID: mdl-19526149

ABSTRACT

We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.


Subject(s)
Brain Injuries/therapy , Mesenchymal Stem Cells/cytology , Neurons/cytology , Animals , Male , Rats , Rats, Wistar
2.
Bull Exp Biol Med ; 136(4): 399-403, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14714094

ABSTRACT

Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.


Subject(s)
Duodenum/blood supply , Duodenum/radiation effects , Gamma Rays , Mast Cells/radiation effects , Radiation Injuries, Experimental/prevention & control , Age Factors , Animals , Catecholamines/metabolism , Duodenum/drug effects , Duodenum/ultrastructure , Follow-Up Studies , Male , Mast Cells/drug effects , Mast Cells/ultrastructure , Metyrapone/pharmacology , Radiation Dosage , Radiation-Protective Agents/pharmacology , Rats , Rats, Wistar , Time Factors , Whole-Body Irradiation
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