ABSTRACT
67 patients with mammary carcinoma were submitted to an immunological control examination. This control comprised 14 tests which determined the efficacy of the immune systems, among others: activity of complement, properdin, lysozyme, and beta-lysin, the rate of immunoglobulins, and the behavior of leucergy, rosette tests, NBT, BLT, and tuberculin test. The thoroughly executed examinations did not show any significant difference between patients with active neoplasms and patients in remission stage. The analysis of the results achieved for patients in an advanced stage (TNM) only showed a significant increase (p less than 0.05) of IgG in stage III/IV. The patients were treated with CVF, levamisole (Decaris), and BCG. The observation period was twelve months. The results achieved were discussed in detail.
Subject(s)
Breast Neoplasms/immunology , Immunization , Adult , BCG Vaccine/therapeutic use , Breast Neoplasms/drug therapy , Complement System Proteins/analysis , Cyclophosphamide/therapeutic use , Female , Fluorouracil/therapeutic use , Humans , Immunoglobulins/analysis , Levamisole/therapeutic use , Lysine/analysis , Middle Aged , Muramidase/analysis , Properdin/analysis , Vincristine/therapeutic useSubject(s)
Granulocytes/enzymology , Muramidase/blood , Myocardial Infarction/enzymology , Adult , Aged , Hemolysis , Humans , Middle AgedSubject(s)
Interferons/therapeutic use , Adult , Animals , Antineoplastic Agents , Child , Clinical Trials as Topic , Haplorhini , Herpes Simplex/drug therapy , Humans , In Vitro Techniques , Interferons/administration & dosage , Interferons/toxicity , Leukopenia/etiology , Macaca fascicularis , Neoplasms/drug therapy , Rabies/drug therapy , Remission, SpontaneousSubject(s)
Carcinoembryonic Antigen/analysis , Neoplasms/diagnosis , Carcinoembryonic Antigen/genetics , Carcinoembryonic Antigen/immunology , Female , Gastrointestinal Diseases/diagnosis , Gastrointestinal Neoplasms/diagnosis , Humans , Lung Neoplasms/diagnosis , Male , Ovarian Cysts/diagnosis , PregnancyABSTRACT
Guinea pigs, 250-350 g body weight, both sexes, were injected with 5X10(8.5) EID50 NDV (Radom strain) intracardially and intraperitoneally simultaneously. The animals were bled by cardiac puncture 0, 3, 6, 12, 24 and 48 hours after injection. After virus inactivation, serum interferon titration was performed in cultures of guinea pig embryo kidney cells with 50 percent plaque inhibition test using VSV. The highest interferon titer (64 u./ml) was found after 6 hours of inductor injection. Interferon titer decreased quickly and after 12 hours it was lower than 16 u./ml. Guinea pig serum interferon induced by NDV was resistant to pH 2 and 56 degrees C during 1 hour. Interferon was inactivated by trypsin. The decribed interferon did not protect heterologous species cells (swine) against Teschen Disease Virus infection. Other properties of this interferon are being studied.
