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Article in Russian | MEDLINE | ID: mdl-8067149

ABSTRACT

The possibility of using sodium nucleinate for the treatment of acute dysentery has been confirmed in experiments on guinea pigs with the use of the keratoconjunctival test as an experimental model. The capacity of sodium nucleinate to enhance the antibiotic sensitivity of shigellae isolated from infected eyes to kanamycin, tetracycline and chloramphenicol has been established. The effect produced by individual ribonucleotides contained in sodium nucleinate have been studied and found to be differently directed.


Subject(s)
Adjuvants, Immunologic/therapeutic use , Dysentery, Bacillary/drug therapy , Keratoconjunctivitis/drug therapy , Nucleic Acids/therapeutic use , Ribonucleotides/therapeutic use , Shigella flexneri , Animals , Disease Models, Animal , Drug Evaluation, Preclinical , Drug Therapy, Combination , Guinea Pigs , Remission Induction , Time Factors
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