[Comments on reconstruction after postcricoid carcinoma surgery]. / Uwagi na temat rekonstrukcji po operacji raka czesci zapiersciennej gardla dolnego.

Within the years 1989-1999, 44 hypopharynx carcinoma operations were held. Five patients have been selected for anterior wall esophagus reconstruction with anterior part of larynx. Preservation of the esophagus posterior wall mucosa and a loss of not more than 4 cm oesophagus were the indication for this kind of reconstruction. One of the patients who underwent the operation died of metastasis within a year, two of them after three and five years because of other diseases. Two patient survived--one three years, and the other one half a year from the operation. The authors would like to indicate the functional results of the treatment.

Role of cysteine endopeptidases in cancerogenesis.

Role of cysteine endopeptidases in cancerogenesis steps: neoplastic transformation, invasion and metastasis is reviewed and discussed. Positive correlation between tumor invasiveness, as well as its metastatic potential and secretion of cysteine endopeptidase (particularly cathepsins B and L) has been documented well in literature. Based on our recent results we postulate that serum endopeptidase-like activity could be used as a marker of cancer aggressiveness in diagnostic procedures in oncology. We also propose that the cysteine endopeptidase inhibitor levels (total, active and latent) could be useful factors for recognising the activation of the organism self-defence mechanisms against cancer. In addition, our idea of use of urinary cysteine peptidase inhibitors (UCPI) as potential anticancer agents is presented and discussed.

Decrease in vivo of cysteine endopeptidases in blood of patients with tumor of the larynx.

Since cysteine endopeptidase (cathepsins B and L) have been proposed to be implicated in tumor malignancy, we have attempted to decrease these in vivo. Large amounts of urine cysteine peptidase inhibitors (UCPI) are present in the urine of patients. Our results indicate protective effects of a UCIP preparation against human serum cysteine endopeptidases.

[Functional recordings of human nasal inferior turbinates -- the device design]. / Zapisy czynnosci naczyn malzowiny dolnej nosa u ludzi--prototyp aparatu.

There is prototype of device presented. It is used in order to record a simultaneous capacitance and resistance vessels functions, of human inferior turbinate. Present results indicate usefulness of device in clinical trials.