Dental trauma in primary dentition and the importance of its preservation until the eruption of permanent successor: a 6-year follow-up case report.

Traumatic dental injuries (TDIs) are a public health concern that requires special attention in primary dentition due to the sequel that can be originated in permanent dentition. This paper aims to report a dental trauma injury highlighting the importance of follow-up the traumatized primary tooth until the eruption of its permanent successor. A 3-year-old female patient referred to a Dental Trauma Care Program (DTCP) in a Brazilian Public University after falling from her own height with the involvement of the deciduous maxillary left central incisor. The child's mother did not seek immediate care. The patient did not have any complaint and the tooth presented an enamel fracture during the clinical examination without radiographic alterations. The procedure performed was occlusal wear and insertion of the patient into the DTCP. After a 6-months clinical and radiographic follow-up, the primary maxillary left central incisor presented crown discoloration and periapical bone rarefaction. The treatment was pulpectomy followed by restoration of the tooth. In the 3-year follow-up, prolonged retention occurred and tooth extraction was the treatment of choice. After a 6-year follow-up, the permanent teeth erupted without any sequelae. TDIs are frequent in the primary dentition and, in some circumstances may interfere with the normal development of the permanent tooth causing irreversible sequelae. This case report reinforces the importance of seeking immediate care whenever dental traumas occur. Besides, a long-term follow-up of the traumatized tooth is essential for successful outcomes. Clinical and radiographic monitoring is fundamental to help dental professionals to decide the best treatment and to minimize potential complications.

Impact of traumatic dental injury treatment on the Oral Health-Related Quality of Life of children, adolescents, and their family: Systematic review and meta-analysis.

BACKGROUND/AIM: Measures of oral health-related quality of life (OHRQoL) are useful in clinical trials to evaluate treatment outcomes. To detect the treatment impact of traumatic dental injuries (TDI) on OHRQoL is extremely relevant. The aim of this study was to assess whether there is scientific evidence of the impact of TDI treatment on OHRQoL of children, adolescents, and their families. MATERIAL AND METHODS: A systematic review and meta-analysis were conducted selecting articles from PubMed, Web of Science, Scopus, Cochrane Library, and Virtual Health Library until May 22nd, 2020. The gray literature, clinical trial registers, and a manual search were performed. Two independent reviewers selected the studies, extracted the data, and assessed the ROBINS-I risk of bias. A meta-analysis was performed using RevMan 5.4 program. The certainty of the evidence was evaluated using the GRADE system. RESULTS: In the electronic search, 413 abstracts and one registered study were found. After removing the duplicates and eligibility application, six studies were included. Individually, the studies presented low to moderate risk of bias and they found that TDI treatment reduces the negative impact on OHRQoL. In the meta-analysis, TDI treatment improved OHRQoL for 8- to 10-year-old children (p = .03; CI 5.19 [0.62, 9.75]) (detected by CPQ 8-10 questionnaire). In the perception of parents, the children, and adolescents who had suffered TDI also had their OHRQoL improved (p = .04; CI 14.77 [0.95, 28.60]) (detected by PPQ and P-CPQ questionnaire) but both evaluations had very low certainty of evidence. CONCLUSION: Treatment of traumatic dental injuries reduces the impact on the OHRQoL of children and adolescents. However, more studies are necessary to detect the TDI treatment influence on OHRQoL of preschoolers and in the family as well to estimate the effects due to outcomes that had a very low certainty of evidence (#CRD42018091210).

Evaluation of the impact of a dental trauma care program on oral health-related quality of life of children and their families.

BACKGROUND/AIM: A traumatic dental injury (TDI) may have physical and psychosocial consequences for children and their families, and it may impact their oral health-related quality of life (OHRQoL). The aim of this study was to assess the OHRQoL of children affected by TDI and their families after enrollment in the Dental Trauma Care Program (DTCP). METHODS: This longitudinal clinical study involved a consecutive sample of 2- to 6-year-old children registered in the DTCP over a period of six years. Parents/caregivers were interviewed and the OHRQoL questionnaire was completed. The Brazilian version of the Early Childhood Oral Health Impact Scale (ECOHIS) was used before and after treatment. The Andreasen criteria were used to classify TDIs. The patients were treated (minimal intervention/invasive intervention) according to TDI severity (uncomplicated/complicated). Based on the Kolmogorov-Smirnov test, the Wilcoxon non-parametric test was used to compare the ECOHIS total scale/subscales/domains before and after enrollment in the DTCP. The longitudinal changes were calculated using effect size measured by the Standardized Response Means (SRM). TDI severity and treatments were also evaluated. RESULTS: The total ECOHIS mean scores were 7.4 ± 9.2 and 0.8 ± 2.5, before and after TDI treatment (p < .001), respectively. ECOHIS scores dropped by 6.6 points after treatment, demonstrating a positive reduction in the impact on OHRQoL, as reflected by the satisfactory responsiveness of ECOHIS (0.9). The changes following treatment, independent of TDI severity and type of treatment, were significant (p < .001) in children and the family section. CONCLUSIONS: The impact of TDI on OHRQoL reduced after the enrollment of patients and their families in the DTCP.

Dental trauma in primary dentition, its effect on permanent successors and on Oral Health-Related Quality of Life: a 4-year follow-up case report.

Traumatic dental injury (TDI) in deciduous teeth can affect itself and subsequent dentition due to its close anatomical relationship with the permanent germ. Besides, it can have psychologically undesirable effects on children and their parents and impact their Oral Health-Related Quality of Life (OHRQoL). In this case report, we aimed to describe a TDI in primary dentition that presented sequel on primary and on permanent dentition as well to describe the impact on OHRQoL after 4 years of follow-up. A 4-year-old boy was referred to the Dental Trauma Care Program (DTCP) six months after an accident at school that resulted in TDI. In deciduous dentition, the tooth 51 presented periapical lesion due to lateral luxation and tooth 61 presented pulp canal obliteration due to a concussion. The teeth received appropriate treatment. After 4 years of follow-up, in the permanent dentition, tooth 11 presented mild disturbance (demarcated opacity) as sequel of TDI in deciduous dentition. The patient's OHRQoL was evaluated throughout this process until the eruption of the permanent tooth. TDI and the sequelae on permanent tooth had a negative impact on the patient's OHRQoL. TDI treatment improved the patient's OHRQoL. This case report reinforces the importance of regular follow-up of traumatized teeth as it can affect both dentitions with a negative impact on OHRQoL.

Impact of complicated and uncomplicated traumatic dental injuries on oral health-related quality of life of preschoolers and their family.

The severity of a traumatic dental injury (TDI) can influence the prognosis of deciduous teeth and the formation of permanent successors. Consequently, it can have a negative influence on the daily lives of children and their parents. The present study aimed to evaluate the impact of complicated and uncomplicated TDI on the oral health-related quality of life (OHRQoL) of preschoolers and their families. A cross-sectional study was carried out according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. After sample calculation and application of the eligibility criteria, 76 children from public preschools (aged 2 to 5 years) with TDI were selected during a period of 5 months. TDI was diagnosed using the Dental Trauma Index and classified according to the severity as complicated or uncomplicated. The Brazilian version of the Early Childhood Oral Health Impact Scale (ECOHIS) was used to determine OHRQoL. The Poisson regression model and Poisson regression model with robust estimates were calculated according to p-values <0.05. The complicated group and the uncomplicated group presented low average impact according to ECOHIS scores and there was no significant difference in the total scale, subscale, and domains (P>0.05) according to the type of TDI. Based on these findings, it can be concluded that severity of TDI did not influence the OHRQoL of preschoolers and their families.

Association of taste receptor gene polymorphisms with dental caries.

This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children's systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39-2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11-1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02-1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries.

Does traumatic dental injury impact oral health-related to quality of life of children and adolescents? Systematic review and meta-analysis.

OBJECTIVE: This systematic review aimed to evaluate the association of traumatic dental injury (TDI) on oral health-related to quality of life (OHRQoL) in children and adolescents. METHODS: A focused structured question using Population (P), Exposition (E), Comparisons (C), Outcomes (O) (PECO) was designed: "Does traumatic dental injury impact OHRQoL of children and adolescents?" A broad search according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was conducted. Evaluation criteria of methodological quality and risk of bias control were applied to selected articles. A fixed-effect model was used for the meta-analysis, and the quality of the evidence was performed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RESULTS: Nineteen studies were qualified with moderate to high quality, and 11 studies were considered for meta-analysis. Negative impact on OHRQoL was detected for children in the symptoms domain (P = .005; IC; -0.07 [-0.12, -0.02]) with moderate certainty of evidence quality level (GRADE). For adolescents, the total scale and all domain presented statistical significance (P < .05) with moderate certainty of evidence in the areas of functional limitation and social well-being (GRADE). CONCLUSIONS: Based on articles with moderate to high quality, the impact of TDI on OHRQoL in children under age 10 was only significant in the symptom domain using Early Childhood Oral Health Impact Scale (ECOHIS). The impact of TDI on OHRQoL in early adolescents aged 11 to 14 was significant in every assessed domain using Child Perception Questionnaire (CPQ11-14). However, future studies should be done improving the available certainty of evidence considered moderate. (CRD42016035686).

Association of taste receptor gene polymorphisms with dental caries

Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children's systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39-2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11-1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02-1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries.

Oral health-related quality of life of 8-10 year-old children with traumatic dental injury

Introduction: Children presents high prevalence of traumatic dental injury (TDI). Objective: It is very important to detect the impact on oral health related to quality of life (OHRQoL) in this age group. Methods: Based on this, a cross sectional study was carried out using a convenience sample. Children from 8-10 years with TDI in permanent teeth were recruited over an 18 month period, from a public University. Data about OHRQoL using the Brazilian version of CPQ 8-10 (B-CPQ 8- 0 ) were collected. TDI were classified according to Andreasen criteria and grouped according to its severity. Variations in the scores and impact of TDI on OHRQoL according to age, gender and TDI severity were examined using nonparametric statistical tests (Kruskall-Wallis and Mann-Whitney test, p<0.05). Results: From a sample of 255 children, 41 healthy children that suffered TDI in permanent were included in the study. The mean B-CPQ 8-10 scores were 29.7 (SD 14.3). Emotional and social wellbeing domais had the highest negative score impact average 8.8 (SD 5.9) and 9.8 (SD 6.3), respectively. Gender or TDI severity did not present relation to impact on OHRQoL. In relation to age, 10-year-old children had more impact on their OHRQoL on the overall scale (p<0.05) and for the functional limitation subscale (p<0.05). Conclusion: TDI impacts negatively on OHRQoL of children aged from 8-10 years old.

Introdução: Crianças apresentam alta prevalência de traumatismo dentário (TD).Objetivo: Detectar o impacto do TD na qualidade de vida relacionada à saúde bucal (QVRSB) nessa faixa etária. Métodos: Um estudo transversal foi realizado com amostra de conveniência recrutando-se crianças de 8-10 anos com TD em dente permanente por um período de 18 meses em clínica pública. Dados sobre a QVRSB foram coletados através da versão brasileira do CPQ 8-10 (B-CPQ 8-10 ). O TD foi classificado de acordo com os critérios de Andreasen e agrupado de acordo com sua gravidade. As variações nos escores e o impacto do TD na QVRSB, de acordo com idade, gênero e gravidade do TD foram examinados por meio de testes estatísticos não paramétricos (teste de Kruskall-Wallis e Mann-Whitney, p <0,05). Resultados: De uma amostra de 255 crianças, 41 crianças saudáveis que sofreram TD em dentes permanentes foram incluídas no estudo. O escore médio do B-CPQ 8-10 foi 29,7 (DP 14,3). Os domínios bem-estar emocional e social apresentaram maior impacto negativo com média de 8,8 (DP 5,9) e 9,8 (DP 6,3), respectivamente. A diferença de gênero e a gravidade do TD não apresentaram relação de impacto na QVRSB. Em relação a idade, crianças de 10 anos tiveram maior impacto na escala global da QVRSB (p <0,05) e na subescala de limitação funcional (p <0,05). Conclusão: O TD impacta negativamente a QVRSB de crianças de 8 a 10 anos de idade.