ABSTRACT
Allergic contact dermatitis to a topical ophthalmic anesthetic, proparacaine, is reported in a patient with refractory glaucoma. His ophthalmologist routinely used a preparation containing this anesthetic, which is an uncommon sensitizer, for measuring the patient's intraocular pressure. That the patient did not apply the medication himself resulted in added difficulty in discovering the iatrogenically induced contact allergy. Avoidance of this anesthetic resulted in resolution of the patient's recurrent bouts of periocular dermatitis and conjunctivitis. The importance of testing patients suspected of having contact allergy to all medications to which they are exposed is emphasized.
Subject(s)
Anesthetics, Local/adverse effects , Dermatitis, Allergic Contact/etiology , Iatrogenic Disease , Propoxycaine/adverse effects , Aged , Conjunctivitis, Allergic/etiology , Dermatitis, Allergic Contact/diagnosis , Glaucoma/diagnosis , Humans , Intraocular Pressure , Male , Patch TestsSubject(s)
Skin Diseases/pathology , Arm , Colloids , Hand Dermatoses/etiology , Hand Dermatoses/pathology , Humans , Male , Middle Aged , Skin/pathology , Skin Diseases/etiology , Sunlight/adverse effectsABSTRACT
Numerous flat and tinea versicolor-like warts developed on the face, trunk, and upper extremities of a 10-year-old boy with human immunodeficiency virus infection. Nucleic acid analysis of involved skin revealed human papillomavirus type 5, which has sometimes been associated with epidermodysplasia verruciformis. This human papillomavirus type has also been described in patients with common variable immunodeficiency and dyskeratosis congenita and in renal allograft recipients. Human immunodeficiency virus infection should be added to the list of immune-related disorders that predispose to widespread flat warts.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Papillomaviridae , Tumor Virus Infections/complications , Warts/complications , Acquired Immunodeficiency Syndrome/pathology , Child , Humans , Male , Tumor Virus Infections/pathology , Warts/microbiology , Warts/pathologyABSTRACT
Treatment of chromoblastomycosis is frequently difficult and unsatisfactory. A representative case is presented of this chronic subcutaneous fungal infection, characterized by warty, cauliflower-like lesions usually on the extremities. Chromoblastomycosis and its treatment are reviewed, with attention to itraconazole, a new triazole compound, as the possible drug of choice.
Subject(s)
Antifungal Agents/therapeutic use , Chromoblastomycosis/drug therapy , Ketoconazole/analogs & derivatives , Antifungal Agents/administration & dosage , Drug Administration Schedule , Humans , Itraconazole , Ketoconazole/administration & dosage , Ketoconazole/therapeutic use , Male , Middle AgedABSTRACT
The purpose of this study was to determine the usefulness of hydrocolloid membrane dressings in the treatment of finger and hand ulcers of scleroderma (progressive systemic sclerosis). Ten pairs of ulcers occurring in seven patients were studied. The ulcers in each patient were treated in a paired comparison trial: one ulcer in each pair was treated with a hydrocolloid membrane; the other was a control. Treatment was continued until at least one ulcer of each pair was healed. The rate of healing of the hydrocolloid membrane-treated ulcers was significantly faster than that of the control ulcers. Pain was rapidly and dramatically reduced in all hydrocolloid membrane-treated ulcers. An infection caused by Pseudomonas aeruginosa occurred in a hydrocolloid membrane-treated ulcer but rapidly responded to topical therapy. Hydrocolloid membrane treatment of sclerodermatous hand ulcers appears to be an effective method of accelerating healing and reducing pain.
Subject(s)
Bandages , Biological Dressings , Colloids , Scleroderma, Systemic/complications , Skin Ulcer/therapy , Adult , Humans , Middle AgedABSTRACT
A patient with acquired immunodeficiency syndrome developed widespread verrucous lesions on the hands, feet, and penis. Histologic analysis revealed typical changes of verruca vulgaris and, from several sites, a transformation toward squamous cell carcinoma. Southern blot analysis of deoxyribonucleic acid from penile wart tissue indicated the presence of a type of human papillomavirus that rarely is associated with carcinoma.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Carcinoma, Squamous Cell/complications , Skin Diseases/complications , Skin Neoplasms/complications , Warts/complications , Adult , Carcinoma, Squamous Cell/microbiology , DNA, Viral/analysis , Humans , Immunoassay , Male , Papillomaviridae/immunology , Penile Diseases/complications , Skin Diseases/pathology , Skin Neoplasms/microbiology , Warts/pathologyABSTRACT
We examined a patient with systemic lupus erythematosus and sepsis due to Pseudomonas aeruginosa. Early in the infection, she developed skin lesions that consisted of indurated tender nodules and hemorrhagic and nonhemorrhagic bullae. Blister fluid contained gram-negative rods, which were identified as P. aeruginosa on culture. Bullae and nodules, as well as ecthyma gangrenosum, can be early cutaneous signs of pseudomonal sepsis.
Subject(s)
Pseudomonas Infections/pathology , Sepsis/complications , Skin Diseases, Infectious/complications , Skin Diseases, Vesiculobullous/complications , Child , Female , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy , Prednisone/therapeutic use , Sepsis/microbiology , Skin/microbiology , Skin/pathology , Skin Diseases, Infectious/pathology , Skin Diseases, Vesiculobullous/microbiology , Skin Diseases, Vesiculobullous/pathologyABSTRACT
We examined two patients with facial lesions of fixed cutaneous sporotrichosis. That condition should be considered in the differential diagnosis of persistent nodules or plaques in this anatomic location.
Subject(s)
Dermatomycoses , Sporotrichosis , Child , Child, Preschool , Face , Female , Humans , MaleABSTRACT
It is obvious clinically that skin of the palms and soles (volar skin) of blacks is lighter in color than black glabrous skin. The same difference obtains in whites, but is much less obvious. The distribution of melanosomes within keratinocytes of the palms and thighs of blacks and whites was compared. Keratinocytes in skin from the thighs of blacks contained only individually dispersed melanosomes, but keratinocytes in skin from the palms of blacks and from the palms and thighs of whites contained complexed melanosomes. Our observation may explain why the incidence of melanoma of volar skin in blacks and whites is similar, whereas melanoma on the glabrous skin of blacks is extremely rare.
