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Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study.

Mangino, Julie E; Firstenberg, Michael S; Milewski, Rita K C; Rhys-Williams, William; Lees, James P; Dane, Aaron; Love, William G; Gonzalez Moreno, Jesus.

Infect Control Hosp Epidemiol ; 44(7): 1171-1173, 2023 Jul.

Article in English | MEDLINE | ID: mdl-36951472

ABSTRACT

We studied 83 cardiac-surgery patients with nasal S. aureus carriage who received 4 intranasal administrations of XF-73 nasal gel or placebo <24 hours before surgery. One hour before surgery, patients exhibited a S. aureus nasal carriage reduction of 2.5 log10 with XF-73 compared to 0.4 log10 CFU/mL for those who received placebo (95% CI, -2.7 to -1.5; P < .0001).

Subject(s)

Cardiac Surgical Procedures , Staphylococcal Infections , Humans , Staphylococcus aureus , Chlorides/therapeutic use , Anti-Bacterial Agents/therapeutic use , Nose , Staphylococcal Infections/drug therapy , Cardiac Surgical Procedures/adverse effects , Carrier State/drug therapy

Handoffs From the Operating Room to the Intensive Care Unit After Cardiothoracic Surgery: From The Society of Thoracic Surgeons Workforce on Critical Care.

Chatterjee, Subhasis; Shake, Jay G; Arora, Rakesh C; Engelman, Daniel T; Firstenberg, Michael S; Geller, Charles M; Hirose, Hitoshi; Lonchyna, Vassyl A; Lytle, Francis T; Milewski, Rita K C; Moosdorf, Rainer G H; Rabin, Joseph; Sanjanwala, Rohan; Galati, Marianne; Whitman, Glenn J.

Ann Thorac Surg ; 107(2): 619-630, 2019 02.

Article in English | MEDLINE | ID: mdl-30500341

Subject(s)

Critical Care , Intensive Care Units , Operating Rooms , Patient Handoff/organization & administration , Perioperative Care/standards , Societies, Medical , Thoracic Surgery , Continuity of Patient Care/organization & administration , Humans , Patient Transfer/methods

ABSTRACT

Subject(s)

Subject(s)

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