ABSTRACT
CLINICAL CASE: A 69-year-old man with a history of acute myeloblastic leukemia-M1 presented with bilateral conjunctival injection. Ophthalmological examination revealed lesions located at the upper tarsal conjunctiva of the right eye and lower tarsal conjunctiva of both eyes. Histological and immunohistochemical studies confirmed conjunctival myeloid sarcoma. The patient died due to multiorgan failure three months later. DISCUSSION: Extramedullary recurrence of leukemia can appear as an ocular manifestation that brings about a recurrence of the leukemia, leading to a poor prognosis.
Subject(s)
Conjunctiva/pathology , Leukemia, Myeloid, Acute/pathology , Leukemic Infiltration/pathology , Sarcoma, Myeloid/etiology , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Fatal Outcome , Humans , Leukemia, Myeloid, Acute/drug therapy , Leukemic Infiltration/drug therapy , Male , Multiple Organ Failure/etiology , Nasal Mucosa/pathology , Recurrence , Sarcoma, Myeloid/drug therapy , Sarcoma, Myeloid/pathology , Skin/pathologyABSTRACT
Caso clínico: Varón de 69 años diagnosticado de leucemia mieloblástica aguda M1 en remisión completa, remitido a Oftalmología por cuadro de ojo rojo no doloroso. Biomicroscópicamente se observan lesiones sobreelevadas asalmonadas en conjuntiva tarsal superior de ojo derecho e inferior de ambos ojos. Mediante estudios histológicos e inmunohistoquímicos se confirma recidiva extramedular en forma de sarcoma mieloide en conjuntiva. El paciente fallece a los 3 meses de un fallo multiorgánico. Discusión: La recidiva extramedular de una leucemia puede presentarse como una manifestación ocular que conlleva una recurrencia de la leucemia, siendo esta de mal pronóstico(AU)
Clinical case: A 69-year-old man with a history of acute myeloblastic leukemia-M1 presented with bilateral conjunctival injection. Ophthalmological examination revealed lesions located at the upper tarsal conjunctiva of the right eye and lower tarsal conjunctiva of both eyes. Histological and immunohistochemical studies confirmed conjunctival myeloid sarcoma. The patient died due to multiorgan failure three months later. Discussion: Extramedullary recurrence of leukemia can appear as an ocular manifestation that brings about a recurrence of the leukemia, leading to a poor prognosis(AU)
Subject(s)
Humans , Sarcoma, Myeloid/complications , Sarcoma, Myeloid/diagnosis , Sarcoma, Myeloid/pathology , Leukemia, Myeloid, Acute/diagnosis , Leukemia, Myeloid, Acute/pathology , Sarcoma, Myeloid/microbiology , Leukemia, Myeloid, Acute/complications , Immunohistochemistry , PrognosisABSTRACT
CASE REPORT: The case of a 66-year-old woman with intermediate uveitis in both eyes and progressive weakness of lower limbs is reported. A human T-lymphotropic virus type 1 (HTLV-1) infection was detected in the serological study, with the patient being diagnosed with tropical spastic paraparesis and HTLV-1 intermediate uveitis. The patient made good progress with oral steroid treatment. DISCUSSION: The clinical and epidemiological aspects of HTLV-1 infection are discussed. We recommend a serological determination of the virus in intermediate uveitis of unknown origin in people from endemic areas or with neurological symptoms.
Subject(s)
HTLV-I Infections , Uveitis, Intermediate/virology , Aged , Female , HumansABSTRACT
Caso Clínico: Se presenta el caso de una mujer de 66 años con uveítis intermedia bilateral y debilidad progresiva de miembros inferiores. En estudio serológico se detecta infección por virus linfotropo humano de células T tipo 1 (VLHT-1), siendo diagnosticada la paciente de paraparesia espástica tropical y uveítis intermedia por VLHT-1. La paciente evolucionó favorablemente con tratamiento corticoideo oral. Discusión: Se comenta la clínica y la epidemiología de la infección por VLHT-1. Se recomienda la realización de serología para el virus en uveítis intermedias no filiadas en inmigrantes de áreas endémicas o con síntomas neurológicos(AU)
Case Report: The case of a 66-year-old woman with intermediate uveitis in both eyes and progressive weakness of lower limbs is reported. A human T-lymphotropic virus type 1 (HTLV-1) infection was detected in the serological study, with the patient being diagnosed with tropical spastic paraparesis and HTLV-1 intermediate uveitis. The patient made good progress with oral steroid treatment. Discussion: The clinical and epidemiological aspects of HTLV-1 infection are discussed. We recommend a serological determination of the virus in intermediate uveitis of unknown origin in people from endemic areas or with neurological symptoms(AU)
Subject(s)
Humans , Female , Aged , Uveitis, Intermediate/microbiology , Human T-lymphotropic virus 1/isolation & purification , Paraparesis, Tropical Spastic/complications , Retroviridae Infections/complicationsABSTRACT
CASE: A case of Descemet's membrane detachment after cataract surgery successfully treated with an injection of sulphur hexafluoride 20% is presented. DISCUSSION: Possible pathogenic mechanisms and available therapeutic options are discussed. We highlight the need for prophylactic measures and the importance of an early detection to prevent further damage.
Subject(s)
Cataract Extraction/adverse effects , Descemet Membrane , Aged , Female , HumansABSTRACT
CASE REPORT: A 46-year-old woman, who presented with right visual acuity loss, was found to have papilledema, and subsequently shown to have ventricular dilatation in a cerebral Magnetic Resonance Imaging (MRI) assessment. Elevated protein levels were found in the cerebrospinal fluid. Spinal MRI revealed the presence of a spinal cord neoplasm. After surgical removal of the tumor, which turned out to be a neurilemmoma, the patient's visual acuity was restored. DISCUSSION: The ocular presentation and the relationship between intracranial hypertension and spinal tumors are discussed. Likewise, the importance of considering the various causes of papilledema is emphasized.
