ABSTRACT
The objective of this study was to review and analyse the chest radiograph (CXR) appearances seen following high dose chemotherapy and autologous bone marrow transplantation (ABMT), and to identify any characteristic patterns. Thirty-one patients underwent ABMT between 1984 and 1989 for high grade lymphoma resistant to conventional chemotherapy. Their case notes and CXRs were reviewed in conjunction with the clinicians. In this small sample of patients, an acute interstitial pattern was seen with pulmonary oedema following bone marrow reinfusion in two cases of the 13 patients showing CXR changes (15%). Otherwise, the CXR changes following ABMT were not specific, although they did alert the clinician to the possibilities of recurrent lymphoma or opportunistic infection, enabling appropriate investigations and treatment to be instituted at an early stage. The complications and CXR changes did not differ greatly from those seen following allogeneic bone marrow transplantation.
Subject(s)
Bone Marrow Transplantation , Hodgkin Disease/diagnostic imaging , Lymphoma, Non-Hodgkin/diagnostic imaging , Radiography, Thoracic , Adolescent , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Combined Modality Therapy , Drug Resistance , Female , Hodgkin Disease/therapy , Humans , Lymphoma, Non-Hodgkin/therapy , Male , Middle Aged , Pulmonary Edema/diagnostic imaging , RecurrenceABSTRACT
Patients presenting with a right iliac fossa (RIF) mass are a diagnostic problem. The objective of this study was to assess the role of ultrasound (US) in their investigation. A prospective series of 50 patients presenting with a clinically suspected RIF mass was examined by US and the finding correlated with the final diagnosis. There was a positive finding in 34 patients (68%). Ultrasound correctly identified the organ of origin in 33 (97%) and was able to guide the patients' further management. In 12 cases no abnormality was found in the RIF, of which 11 had no positive findings at follow-up and one was shown to have an unrelated abnormality at laparotomy. In four cases the findings were due to normal variants. Ultrasound is the imaging modality of first choice in patients presenting with a RIF mass.
Subject(s)
Abdominal Neoplasms/diagnostic imaging , Female Urogenital Diseases/diagnostic imaging , Gastrointestinal Diseases/diagnostic imaging , Male Urogenital Diseases , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective Studies , UltrasonographyABSTRACT
The results of transcatheter renal artery embolization are presented in a small group of patients with end-stage renal disease. Five of the patients were suffering from severe drug-resistant hypertension, one from rejection of a renal transplant and one had heavy haematuria from a transplant kidney. All seven patients benefited from the procedure with no significant morbidity. The procedure of renal artery embolization and its potential complications are discussed. It is concluded that renal ablation by transcatheter embolization is not only effective, but also has a significantly lower morbidity and mortality than surgical nephrectomy in this group of patients with end-stage renal disease and associated problems.
Subject(s)
Embolization, Therapeutic/methods , Hypertension/therapy , Kidney Failure, Chronic/therapy , Renal Artery , Adult , Antihypertensive Agents/therapeutic use , Blood Pressure/drug effects , Combined Modality Therapy , Drug Resistance , Embolization, Therapeutic/adverse effects , Evaluation Studies as Topic , Female , Humans , Hypertension/etiology , Kidney Failure, Chronic/complications , MaleSubject(s)
Ascites/surgery , Peritoneovenous Shunt , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Palliative CareABSTRACT
The case history of an 84 year old woman presenting with a metachronous aneurysm of the infrarenal abdominal aorta is presented. At operation this second aneurysm was replaced by a further straight tube Dacron inlay graft. This report raises the important question as to whether the whole of the infrarenal aorta should be replaced when resecting an infrarenal abdominal aortic aneurysm, rather than the more conventional approach of suturing the graft to the neck of the aneurysm above and the aortic bifurcation below.
Subject(s)
Aortic Aneurysm/surgery , Aged , Aged, 80 and over , Aorta, Abdominal , Blood Vessel Prosthesis , Female , Humans , Polyethylene Terephthalates , Postoperative Complications/surgeryABSTRACT
The effect of diethylstilbestrol injection on the activities of phosphatidylcholine biosynthetic enzymes in rooster liver has been determined. Choline kinase activity was stimulated within 4 h after the first hormone injection. By the third day enzyme activity reached 5.47 nmol . min-1 . mg-1 protein compared to control values (1.83 nmol . min-1 . mg-1 protein) which were unchanged during the the experiment. CTP : phosphocholine cytidylyltransferase activity was unaffected until Day 3 when its activity was 50% that of control values. When assayed in the presence of exogenous phospholipid, no significant change was noted in cytidylyltransferase activity. The activity of CDPcholine : 1,2-diacylglycerol phosphocholinetransferase was not altered by the hormone injections. The activity of phosphatidylethanolamine-N-methyltransferase gradually increased so that by Day 3, the enzyme activity was elevated 2-fold (0.12 to 0.24 nmol methyl group transferred per mg microsomal protein). These results are consistent with earlier in vivo studies (Vigo, C. and Vance, D.E. (1981) Eur. J. Biochem., in the press) that indicated a stimulation of phosphatidylcholine biosynthesis via CDPcholine during the first 2 days of diethylstilbestrol injection and inhibition on the third day.
