Whole Body PMHS Response in Injurious Experimental Accelerative Loading Events.

Previous studies involving whole-body post-mortem human surrogates (PHMS) have generated biomechanical response specifications for physically simulated accelerative loading intended to reproduce seat and floor velocity histories occurring in under-body blast (UBB) events (e.g.,. References 10, 11, 21 These previous studies employed loading conditions that only rarely produced injuries to the foot/ankle and pelvis, which are body regions of interest for injury assessment in staged UBB testing using anthropomorphic test devices. To investigate more injurious whole-body conditions, three series of tests were conducted with PMHS that were equipped with military personal protective equipment and seated in an upright posture. These tests used higher velocity and shorter duration floor and seat inputs than were previously used with the goal of producing pelvis and foot/ankle fractures. A total of nine PMHS that were approximately midsize in stature and mass were equally allocated across three loading conditions, including a 15.5 m/s, 2.5 ms time-to-peak (TTP) floor velocity pulse with a 10 m/s, 7.5 ms TTP seat pulse; a 13 m/s, 2.5 ms TTP floor pulse with a 9.0 m/s, 5 ms TTP seat pulse; and a 10 m/s, 2.5 ms TTP floor pulse with a 6.5 m/s, 7.5 ms TTP seat pulse. In the first two conditions, the seat was padded with a ~ 120-mm-thick foam cushion to elongate the pulse experienced by the PMHS. Of the nine PMHS tests, five resulted in pelvic ring fractures, five resulted in a total of eight foot/ankle fractures (i.e., two unilateral and three bilateral fractures), and one produced a femur fracture. Test results were used to develop corridors describing the variability in kinematics and in forces applied to the feet, forces applied to the pelvis and buttocks in rigid seat tests, and in forces applied to the seat foam in padded seat tests. These corridors and the body-region specific injury/no-injury response data can be used to assess the performance and predictive capability of anthropomorphic test devices and computational models used as human surrogates in simulated UBB testing.

Kinematic and Biomechanical Response of Post-Mortem Human Subjects Under Various Pre-Impact Postures to High-Rate Vertical Loading Conditions.

Limited data exist on the injury tolerance and biomechanical response of humans to high-rate, under-body blast (UBB) loading conditions that are commonly seen in current military operations, and there are no data examining the influence of occupant posture on response. Additionally, no anthropomorphic test device (ATD) currently exists that can properly assess the response of humans to high-rate UBB loading. Therefore, the purpose of this research was to examine the response of post-mortem human surrogates (PMHS) in various seated postures to high-rate, vertical loading representative of those conditions seen in theater. In total, six PMHS tests were conducted using loading pulses applied directly to the pelvis and feet of the PMHS: three in an acute posture (foot, knee, and pelvis angles of 75°, 75°, and 36°, respectively), and three in an obtuse posture (15° reclined torso, and foot, knee, and pelvis angles of 105°, 105°, and 49.5°, respectively). Tests were conducted with a seat velocity pulse that peaked at ~4 m/s with a 30-40 ms time to peak velocity (TTP) and a floor velocity that peaked at 6.9-8.0 m/s (2-2.75 ms TTP). Posture condition had no influence on skeletal injuries sustained, but did result in altered leg kinematics, with leg entrapment under the seat occurring in the acute posture, and significant forward leg rotations occurring in the obtuse posture. These data will be used to validate a prototype ATD meant for use in high-rate UBB loading scenarios.

Development, Evaluation, and Sensitivity Analysis of Parametric Finite Element Whole-Body Human Models in Side Impacts.

Occupant stature and body shape may have significant effects on injury risks in motor vehicle crashes, but the current finite element (FE) human body models (HBMs) only represent occupants with a few sizes and shapes. Our recent studies have demonstrated that, by using a mesh morphing method, parametric FE HBMs can be rapidly developed for representing a diverse population. However, the biofidelity of those models across a wide range of human attributes has not been established. Therefore, the objectives of this study are 1) to evaluate the accuracy of HBMs considering subject-specific geometry information, and 2) to apply the parametric HBMs in a sensitivity analysis for identifying the specific parameters affecting body responses in side impact conditions. Four side-impact tests with two male post-mortem human subjects (PMHSs) were selected to evaluate the accuracy of the geometry and impact responses of the morphed HBMs. For each PMHS test, three HBMs were simulated to compare with the test results: the original Total Human Model for Safety (THUMS) v4.01 (O-THUMS), a parametric THUMS (P-THUMS), and a subject-specific THUMS (S-THUMS). The P-THUMS geometry was predicted from only age, sex, stature, and BMI using our statistical geometry models of skeleton and body shape, while the S-THUMS geometry was based on each PMHS's CT data. The simulation results showed a preliminary trend that the correlations between the PTHUMS- predicted impact responses and the four PMHS tests (mean-CORA: 0.84, 0.78, 0.69, 0.70) were better than those between the O-THUMS and the normalized PMHS responses (mean-CORA: 0.74, 0.72, 0.55, 0.63), while they are similar to the correlations between S-THUMS and the PMHS tests (mean-CORA: 0.85, 0.85, 0.67, 0.72). The sensitivity analysis using the PTHUMS showed that, in side impact conditions, the HBM skeleton and body shape geometries as well as the body posture were more important in modeling the occupant impact responses than the bone and soft tissue material properties and the padding stiffness with the given parameter ranges. More investigations are needed to further support these findings.

Response and Tolerance of Female and/or Elderly PMHS to Lateral Impact.

Eight whole fresh-frozen cadavers (6 female, 2 male) that were elderly and/or female were laterally impacted using UMTRI's dual-sled side-impact test facility. Cadavers were not excluded on the basis of old age or bone diseases that affect tolerance. A thinly padded, multi-segment impactor was used that independently measured force histories applied to the shoulder, thorax, abdomen, greater trochanter, iliac wing, and femur of each PMHS. Impactor plates were adjusted vertically and laterally toward the subject so that contact with body regions occurred simultaneously and so that each segment contacted the same region on every subject. This configuration minimized the effects of body shape on load sharing between regions. Prior to all tests, cadavers were CT scanned to check for pre-existing skeletal injuries. Cadavers were excluded if they had preexisting rib fractures or had undergone CPR. Cadavers were instrumented with strain gages at the posterolateral, lateral, and anterolateral portions of the struck-side ribs, and chestbands were positioned on the upper and lower thorax. Cadavers were first impacted at 3 m/s. If two or fewer rib fractures occurred, as determined using strain gage data and a post-test CT scan, a second impact was performed at 6 m/s on the contralateral side of the body. Five of the eight 3-m/s tests produced AIS 3+ level injuries. All three of the 6-m/s tests produced AIS 3+ injury. Response corridors were developed for each body region using the Maltese alignment method with impulse-momentum normalization. Corridors describing upper and lower thorax deflection were generated from chestband data. An injury risk curve developed from the deflections associated with AIS 3+ injury associates a 50% probability of AIS 3+ rib fracture with 25.6% half-thorax deflection for the population used in this study.

Biomechanical considerations for assessing interactions of children and small occupants with inflatable seat belts.

NHTSA estimates that more than half of the lives saved (168,524) in car crashes between 1960 and 2002 were due to the use of seat belts. Nevertheless, while seat belts are vital to occupant crash protection, safety researchers continue efforts to further enhance the capability of seat belts in reducing injury and fatality risk in automotive crashes. Examples of seat belt design concepts that have been investigated by researchers include inflatable, 4-point, and reverse geometry seat belts. In 2011, Ford Motor Company introduced the first rear seat inflatable seat belts into production vehicles. A series of tests with child and small female-sized Anthropomorphic Test Devices (ATD) and small, elderly female Post Mortem Human Subjects (PMHS) was performed to evaluate interactions of prototype inflatable seat belts with the chest, upper torso, head and neck of children and small occupants, from infants to young adolescents. Tests simulating a 6-year-old child asleep in a booster seat, with its head lying directly on its shoulder on top of the inflatable seat belt, were considered by engineering judgment, to represent a worst case scenario for interaction of an inflating seat belt with the head and neck of a child and/or small occupant. All evaluations resulted in ATD responses below Injury Assessment Reference Values reported by Mertz et al. (2003). In addition, the tests of the PMHS subjects resulted in no injuries from interaction of the inflating seat belt with the heads, necks, and chests of the subjects. Given the results from the ATD and PMHS tests, it was concluded that the injury risk to children and small occupants from deployment of inflatable seat belt systems is low.

PMHS impact response in 3 m/s and 8 m/s nearside impacts with abdomen offset.

Lateral impact tests were performed using seven male post-mortem human subjects (PMHS) to characterize the force-deflection response of contacted body regions, including the lower abdomen. All tests were performed using a dual-sled, side-impact test facility. A segmented impactor was mounted on a sled that was pneumatically accelerated into a second, initially stationary sled on which a subject was seated facing perpendicular to the direction of impact. Positions of impactor segments were adjusted for each subject so that forces applied to different anatomic regions, including thorax, abdomen, greater trochanter, iliac wing, and thigh, could be independently measured on each PMHS. The impactor contact surfaces were located in the same vertical plane, except that the abdomen plate was offset 5.1 cm towards the subject. The masses of the sleds and the force- deflection characteristics of the energy-absorbing interface material between the sleds were set to provide the impactor sled with a velocity profile that matched the average driver door velocity history produced in a series of side NCAP tests. Impactor padding was also selected so that average ATD pelvis and thorax responses from the same series of side NCAP tests were reproduced when the ATD used in these tests was impacted using the average door-velocity history. Each subject was first impacted on one side of the body using an initial impactor speed of 3 m/s. If a post-test CT scan and strain-gage data revealed two or fewer non-displaced rib fractures, then the PMHS was impacted on the contralateral side of the body at a speed of 8 m/s or 10 m/s. The results of tests in the 3 m/s and 8 m/s conditions were used to develop force-deflection response corridors for the abdomen, force history response corridors for the pelvis (iliac wing and greater trochanter), the midthigh, and the thorax. Response corridors for the lateral acceleration of the pelvis were also developed. Future work will compare side impact ATD responses to these response corridors.

Effect of frozen storage on dynamic tensile properties of human placenta.

Dynamic mechanical properties of placenta tissue are needed to develop computational models of pregnant occupants for use in designing restraint systems that protect the fetus and mother. Tests were performed on 21 samples obtained from five human placentas at a rate of 1200 %/s using a set of custom designed thermoelectrically cooled clamps. Approximately half of the samples from all five subjects were tested within 48 h of delivery. The remaining samples were frozen for 5-7 days and then thawed before testing. True failure stresses and strains were not significantly different between fresh and frozen samples (p-value = 0.858 and 0.551, respectively), suggesting that soft tissue may be stored frozen up to a week without adversely affecting dynamic material response.

Biomechanical assessment of a rear-seat inflatable seatbelt in frontal impacts.

This study evaluated the biomechanical performance of a rear-seat inflatable seatbelt system and compared it to that of a 3-point seatbelt system, which has a long history of good real-world performance. Frontal-impact sled tests were conducted with Hybrid III anthropomorphic test devices (ATDs) and with post mortem human subjects (PMHS) using both restraint systems and a generic rear-seat configuration. Results from these tests demonstrated: a) reduction in forward head excursion with the inflatable seatbelt system when compared to that of a 3-point seatbelt and; b) a reduction in ATD and PMHS peak chest deflections and the number of PMHS rib fractures with the inflatable seatbelt system and c) a reduction in PMHS cervical-spine injuries, due to the interaction of the chin with the inflated shoulder belt. These results suggest that an inflatable seatbelt system will offer additional benefits to some occupants in the rear seats. Further research is needed to assess the field effectiveness, customer comfort and acceptance and change in the belt usage rate with the inflatable seatbelt system.

A stochastic visco-hyperelastic model of human placenta tissue for finite element crash simulations.

Placental abruption is the most common cause of fetal deaths in motor-vehicle crashes, but studies on the mechanical properties of human placenta are rare. This study presents a new method of developing a stochastic visco-hyperelastic material model of human placenta tissue using a combination of uniaxial tensile testing, specimen-specific finite element (FE) modeling, and stochastic optimization techniques. In our previous study, uniaxial tensile tests of 21 placenta specimens have been performed using a strain rate of 12/s. In this study, additional uniaxial tensile tests were performed using strain rates of 1/s and 0.1/s on 25 placenta specimens. Response corridors for the three loading rates were developed based on the normalized data achieved by test reconstructions of each specimen using specimen-specific FE models. Material parameters of a visco-hyperelastic model and their associated standard deviations were tuned to match both the means and standard deviations of all three response corridors using a stochastic optimization method. The results show a very good agreement between the tested and simulated response corridors, indicating that stochastic analysis can improve estimation of variability in material model parameters. The proposed method can be applied to develop stochastic material models of other biological soft tissues.

Quantifying dynamic mechanical properties of human placenta tissue using optimization techniques with specimen-specific finite-element models.

Motor-vehicle crashes are the leading cause of fetal deaths resulting from maternal trauma in the United States, and placental abruption is the most common cause of these deaths. To minimize this injury, new assessment tools, such as crash-test dummies and computational models of pregnant women, are needed to evaluate vehicle restraint systems with respect to reducing the risk of placental abruption. Developing these models requires accurate material properties for tissues in the pregnant abdomen under dynamic loading conditions that can occur in crashes. A method has been developed for determining dynamic material properties of human soft tissues that combines results from uniaxial tensile tests, specimen-specific finite-element models based on laser scans that accurately capture non-uniform tissue-specimen geometry, and optimization techniques. The current study applies this method to characterizing material properties of placental tissue. For 21 placenta specimens tested at a strain rate of 12/s, the mean failure strain is 0.472+/-0.097 and the mean failure stress is 34.80+/-12.62 kPa. A first-order Ogden material model with ground-state shear modulus (mu) of 23.97+/-5.52 kPa and exponent (alpha(1)) of 3.66+/-1.90 best fits the test results. The new method provides a nearly 40% error reduction (p<0.001) compared to traditional curve-fitting methods by considering detailed specimen geometry, loading conditions, and dynamic effects from high-speed loading. The proposed method can be applied to determine mechanical properties of other soft biological tissues.

Characterization of knee-thigh-hip response in frontal impacts using biomechanical testing and computational simulations.

Development and validation of crash test dummies and computational models that are capable of predicting the risk of injury to all parts of the knee-thigh-hip (KTH) complex in frontal impact requires knowledge of the force transmitted from the knee to the hip under knee impact loading. To provide this information, the knee impact responses of whole and segmented cadavers were measured over a wide range of knee loading conditions. These data were used to develop and help validate a computational model, which was used to estimate force transmitted to the cadaver hip. Approximately 250 tests were conducted using five unembalmed midsize male cadavers. In these tests, the knees were symmetrically impacted with a 255-kg padded impactor using three combinations of knee-impactor padding and velocity that spanned the range of knee loading conditions produced in FMVSS 208 and NCAP tests. Each subject was tested in four conditions. Following test of whole seated cadavers, the subjects were impacted after the connection between the thigh flesh and pelvis was cut, after the thigh flesh was removed, and after the torso was removed. Applied force and femur and pelvis acceleration data from these tests and results of other studies were used with data on static body segment masses to develop and validate a one-dimensional lumped-parameter model of the body. Simulation of the whole body cadaver tests performed with this model predict that approximately 54% of the peak force applied to the knee was transmitted to the hip for all three impact velocities. Additional simulations with the model in which knee impact conditions were varied over a wider range of loading conditions indicate that the percentage drop in force between the knee and the hip is relatively constant over the range of knee impact conditions that are of interest for injury assessment. Simulation results also indicate that high-rate, short-duration knee loading by a rigid surface is more likely to produce knee/distal femur fractures and less likely to produce hip fractures due to laxity in the hip that delays recruitment of pelvis mass and the development of fracture-level forces at the hip until after the fracture tolerance of the knee/femur has been exceeded.