Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Am J Physiol Gastrointest Liver Physiol ; 286(4): G683-91, 2004 Apr.
Article in English | MEDLINE | ID: mdl-14615283

ABSTRACT

The mechanism(s) underlying stress-induced colonic hypersensitivity (SICH) are incompletely understood. Our aims were to assess the acute and delayed (24 h) effect of water avoidance (WA) stress on visceral nociception in awake male Wistar rats and to evaluate the role of two stress-related modulation systems: the substance P/neurokinin-1 receptor (SP/NK(1)R) and the corticotropin-releasing factor (CRF)/CRF(1) receptor (CRF/CRF(1)R) systems, as well as the possible involvement of the sympathetic nervous system. Visceral pain responses were measured as the visceromotor response to colorectal distension (CRD) at baseline, immediately after WA and again 24 h later. The NK(1)R antagonists RP-67580 and SR-140333 and the CRF(1)R antagonist CP-154526 were injected 15 min before WA or 1 h before the CRD on day 2. Chemical sympathectomy was performed by repeated injection of 6-hydroxydopamine. WA stress resulted in a significant increase in the visceromotor response on day 2, but no change immediately after WA. Injection of CP-154526 abolished delayed SICH when applied either before WA stress or before the CRD on day 2. Both NK(1)R antagonists only decreased SICH when injected before the CRD on day 2. Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK(1)R and CRF(1)R activation, but not sympathetic nervous system activation, play a role in the development of SICH.


Subject(s)
Colon/physiopathology , Hypersensitivity, Delayed/physiopathology , Receptors, Corticotropin-Releasing Hormone/physiology , Receptors, Neurokinin-1/physiology , Animals , Colon/innervation , Electromyography , Fear/physiology , Immunohistochemistry , Indoles/pharmacology , Isoindoles , Male , Muscle, Smooth/innervation , Muscle, Smooth/physiology , Neurokinin-1 Receptor Antagonists , Nociceptors/physiology , Physical Stimulation , Piperidines/pharmacology , Pyrimidines/pharmacology , Pyrroles/pharmacology , Quinuclidines/pharmacology , Rats , Rats, Wistar , Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors , Stress, Psychological/physiopathology , Sympathectomy, Chemical , Sympathetic Nervous System/physiology
SELECTION OF CITATIONS
SEARCH DETAIL
...