1.
Clin Infect Dis
; 76(3): e1261-e1265, 2023 02 08.
Article
in English
| MEDLINE
| ID: mdl-35974429
ABSTRACT
We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.
Subject(s)
Acinetobacter Infections , Acinetobacter baumannii , Humans , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Acinetobacter baumannii/genetics , Drug Resistance, Multiple, Bacterial/genetics , Microbial Sensitivity Tests , Acinetobacter Infections/drug therapy , Acinetobacter Infections/epidemiology , Disease Outbreaks , Intensive Care Units , Cefiderocol
2.
Am J Trop Med Hyg
; 99(4): 1062-1065, 2018 10.
Article
in English
| MEDLINE
| ID: mdl-30062993
ABSTRACT
We report a fatal case of Lassa fever diagnosed in the United States in a Liberian traveler. We describe infection control protocols and public health response. One contact at high risk became symptomatic, but her samples tested negative for Lassa virus; no secondary cases occurred among health care, family, and community contacts.