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1.
Lancet HIV ; 2(6): e229-35, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26423195

ABSTRACT

BACKGROUND: Many people with HIV are undiagnosed. Early diagnosis saves lives and reduces onward transmission. We assessed whether an education programme promoting rapid HIV testing in general practice would lead to increased and earlier HIV diagnosis. METHODS: In this cluster randomised controlled trial in Hackney (London, UK), general practices were randomly assigned (1:1) to offer either opt-out rapid HIV testing to newly registering adults or continue usual care. All practices were invited to take part. Practices were randomised by an independent clinical trials unit statistician with a minimisation program, maintaining allocation concealment. Neither patients nor investigators were masked to treatment allocation. The primary outcome was CD4 count at diagnosis. Secondary outcomes were rate of diagnosis, proportion with CD4 count less than 350 cells per µL, and proportion with CD4 count less than 200 cells per µL. This study is registered with ClinicalTrials.gov, number ISRCTN63473710. FINDINGS: 40 of 45 (89%) general practices agreed to participate: 20 were assigned to the intervention group (44 971 newly registered adult patients) and 20 to the control group (38 464 newly registered adult patients), between April 19, 2010, and Aug 31, 2012. Intervention practices diagnosed 32 people with HIV versus 14 in control practices. Mean CD4 count at diagnosis was 356 cells per µL (SD 254) intervention practices versus 270 (SD 257) in control practices (adjusted difference of square root CD4 count 3·1, 95% CI -1·2 to 7·4; p=0·16);); in a pre-planned sensitivity analysis excluding patients diagnosed via antenatal care, the difference was 6·4 (95% CI, 1·2 to 11·6; p=0·017). Rate of HIV diagnosis was 0·30 (95% CI 0·11 to 0·85) per 10 000 patients per year in intervention practices versus 0·07 (0·02 to 0·20) in control practices (adjusted ratio of geometric means 4·51, 95% CI 1·27 to 16·05; p=0·021). 55% of patients in intervention practices versus 73% in control practices had CD4 count less than 350 cells per µL (risk ratio 0·75, 95% CI 0·53 to 1·07). 28% versus 46% had CD4 count less than 200 cells per µL (0·60, 0·32 to 1·13). All patients diagnosed by rapid testing were successfully transferred into specialist care. No adverse events occurred. INTERPRETATION: Promotion of opt-out rapid testing in general practice led to increased rate of diagnosis, and might increase early detection, of HIV. We therefore recommend implementation of HIV screening in general practices in areas with high HIV prevalence. FUNDING: UK Department of Health, NHS City and Hackney.


Subject(s)
HIV Infections/diagnosis , Health Promotion , Adolescent , Adult , CD4 Lymphocyte Count , Early Diagnosis , Female , HIV Infections/blood , Humans , London , Male , Middle Aged , Primary Health Care , Young Adult
3.
Emerg Nurse ; 19(8): 14-8, 2011 Dec.
Article in English | MEDLINE | ID: mdl-22268343

ABSTRACT

This article offers a literature review of the benefits of, and problems associated with, a standardised opt-out screening programme for HIV, and the attitudes of healthcare professionals and patients to its potential introduction in emergency departments. There is a lack of research on the subject in the UK and so the article relies on work undertaken in the US and on opt-out testing in antenatal services in the UK. It reviews the potential benefits of such a programme, in particular the opportunities it offers to improve public health and reduced the stigma associated with HIV, and discusses the issue of consent.


Subject(s)
AIDS Serodiagnosis/statistics & numerical data , Emergency Service, Hospital , HIV Infections/prevention & control , Mass Screening/methods , Patient Acceptance of Health Care , Humans , Informed Consent/standards , Mass Screening/psychology , Reference Standards , Social Stigma
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