The virtual pediatric standardized patient application: formative evaluation findings.

This paper presents formative (i.e., not final project) evaluation data from the use of a responsive virtual human training application by medical students rotating through Pediatrics and by Pediatric medical educators. We are encouraged by the evaluation results and believe the iterative development strategies employed and the subsequent refinements in the scenarios will lead to important instructional and assessment tools for medical educators.

Quantitative structure-activity relationships of phenolic compounds causing apoptosis.

A study of a variety of phenolic compounds (simple phenols, estradiol, bisphenol A, diethylstilbesterol) on their action on L1210 leukemia cells led to the formulation of the following QSAR for apoptosis:log 1/C=-3.16 Clog P+2.77 CMR-3.76n=11, r(2)=0.939, s=0.630, q(2)=0.892C is the molar concentration causing 25% apoptosis, Clog P is the calculated octanol/water partition coefficient and CMR is the calculated molecular refractivity. Our results imply the significance of characterization of the phenolic compounds with apoptotic activity and the development of new agents for cancer therapy.