Subject(s)
Antipsychotic Agents/therapeutic use , Clozapine/therapeutic use , Pirenzepine/analogs & derivatives , Schizophrenia/drug therapy , Adult , Animals , Benzodiazepines , Clozapine/administration & dosage , Drug Administration Schedule , Humans , Male , Olanzapine , Pirenzepine/administration & dosage , Pirenzepine/therapeutic use , Schizophrenic Psychology , Treatment Outcome , Water Intoxication/epidemiology , Water Intoxication/etiologyABSTRACT
OBJECTIVE: To determine whether or not risperidone is efficacious in treating self-induced water intoxication in patients with chronic schizophrenia. METHOD: We carried out a prospective 11-month open-label study using risperidone to treat 8 men with chronic schizophrenia and self-induced water intoxication. RESULTS: The 8 men were not able to reduce their fluid consumption compared with their baseline intake. Risperidone, however, significantly decreased the Brief Psychiatric Rating Scale (BPRS) scores of this very chronic group. CONCLUSIONS: Although risperidone decreased schizophrenic symptoms, it did not have significant efficacy in treating self-induced water intoxication. This study may have implications for the treatment of addictive behaviour.
Subject(s)
Antipsychotic Agents/therapeutic use , Risperidone/therapeutic use , Schizophrenia/drug therapy , Schizophrenic Psychology , Water Intoxication/drug therapy , Adult , Antipsychotic Agents/adverse effects , Chronic Disease , Drinking/drug effects , Humans , Male , Middle Aged , Prospective Studies , Psychiatric Status Rating Scales , Risperidone/adverse effects , Schizophrenia/diagnosis , Treatment Outcome , Water Intoxication/psychologySubject(s)
Antipsychotic Agents/adverse effects , Isoxazoles/adverse effects , Piperidines/adverse effects , Priapism/chemically induced , Schizophrenia, Paranoid/drug therapy , Antipsychotic Agents/administration & dosage , Chronic Disease , Drug Therapy, Combination , Humans , Isoxazoles/administration & dosage , Lithium Carbonate/administration & dosage , Lithium Carbonate/adverse effects , Lorazepam/administration & dosage , Lorazepam/adverse effects , Male , Middle Aged , Piperidines/administration & dosage , Risperidone , Schizophrenia, Paranoid/psychologyABSTRACT
The authors conducted a controlled, prospective 4-month study of 10 male inpatients with chronic schizophrenia and polydipsia. The five men who were treated with group psychotherapy drank significantly less fluid than the five men not given this therapy. The effect of group psychotherapy quickly dissipated in the follow-up period, indicating the need for ongoing treatment.
Subject(s)
Psychotherapy, Group , Schizophrenic Psychology , Water Intoxication/therapy , Adolescent , Adult , Body Weight , Drinking , Follow-Up Studies , Hospitalization , Humans , Male , Prospective Studies , Schizophrenia/therapy , Water Intoxication/psychologyABSTRACT
Twenty male chronic schizophrenics suffering from self-induced water intoxication were administered a 15 item questionnaire to assess their understanding of and attitudes toward drinking fluids. Eighty-five percent stated they drank excessive amounts of fluids in order to feel better. These findings have implications for the treatment of patients with this disorder.
Subject(s)
Attitude to Health , Drinking , Schizophrenic Psychology , Water Intoxication/psychology , Data Collection , Humans , Male , Motivation , Psychiatric Status Rating Scales , Schizophrenia/therapy , Water Intoxication/etiologyABSTRACT
Eight men with chronic schizophrenia and self-induced water intoxication showed marked individual differences in their serum sodium levels. The severity of the intoxication symptoms reflected the amount and speed of change in sodium levels rather than the absolute sodium values.
Subject(s)
Schizophrenia/blood , Schizophrenic Psychology , Sodium/blood , Water Intoxication/blood , Adult , Circadian Rhythm , Drinking , Humans , Hyponatremia/diagnosis , Hyponatremia/etiology , Male , Middle Aged , Schizophrenia/complications , Water Intoxication/complications , Water Intoxication/diagnosis , Weight GainSubject(s)
Behavior Therapy/methods , Drinking , Schizophrenia/therapy , Schizophrenic Psychology , HumansABSTRACT
According to Feighner criteria, alcohol abuse was significantly more common among 17 schizophrenic male inpatients with self-induced water intoxication than among 17 matched schizophrenic control inpatients. The alcohol abuse had begun 8-22 years before the diagnosis of water intoxication.
