ABSTRACT
The review surveys current literature on microbiological synthesis and modification of prostaglandins. Three possible approaches to the use of microorganisms for prostaglandin production are considered including synthesis de novo, arachidonic acid transformation, and prostaglandin modifications. The most typical reactions of prostaglandin transformations by microorganisms are analysed: hydrolysis, hydroxylation, reduction and beta-oxidation.
Subject(s)
Bacteria/metabolism , Fungi/metabolism , Prostaglandins/biosynthesis , Biotransformation , Chemical Phenomena , Chemistry , Microbiological Techniques , Prostaglandins/metabolismABSTRACT
The kinetics of phenylacetamide hydrolysis catalyzed by polyacrylamide gel-immobilized penicillinamidase were studied. The Km and Kp values obtained were compared to the literary data for the specific substrate--benzylpenicillin. It was shown that the type of inhibition by the reaction product was the same, whereas the efficiency of binding of phenylacetic acid depended on the substrate structure.